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Q1J9R0 (Q1J9R0_STRPB) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Isoprenyl transferase HAMAP-Rule MF_01139
EC=2.5.1.- HAMAP-Rule MF_01139
Gene names
Name:uppS EMBL ABF36751.1
Ordered Locus Names:MGAS2096_Spy1699
OrganismStreptococcus pyogenes serotype M12 (strain MGAS2096) [Complete proteome] [HAMAP] EMBL ABF36751.1
Taxonomic identifier370553 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacilli › Lactobacillales › Streptococcaceae › Streptococcus ›

Protein attributes

Sequence length249 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids By similarity. HAMAP-Rule MF_01139

Cofactor

Binds 2 magnesium ions per subunit By similarity. HAMAP-Rule MF_01139

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_01139

Sequence similarities

Belongs to the UPP synthase family. RuleBase RU003962 HAMAP-Rule MF_01139

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site731Proton acceptor By similarity HAMAP-Rule MF_01139
Metal binding251Magnesium By similarity HAMAP-Rule MF_01139
Metal binding2161Magnesium By similarity HAMAP-Rule MF_01139
Binding site301Substrate By similarity HAMAP-Rule MF_01139
Binding site381Substrate By similarity HAMAP-Rule MF_01139
Binding site421Substrate By similarity HAMAP-Rule MF_01139
Binding site741Substrate By similarity HAMAP-Rule MF_01139
Binding site761Substrate By similarity HAMAP-Rule MF_01139
Binding site1971Substrate By similarity HAMAP-Rule MF_01139

Sequences

Sequence LengthMass (Da)Tools
Q1J9R0 [UniParc].

Last modified June 13, 2006. Version 1.
Checksum: 1F824680944EA60E

FASTA24928,238
        10         20         30         40         50         60 
MFGLKAKSTK KVLGSIPKHI GIIMDGNGRW AKKRLKPRVF GHKAGMDALQ EVTITASELG 

        70         80         90        100        110        120 
VKVLTVYAFS TENWSRPQDE VSFIMNLPVT FFDKYVPVLH ENNVKIQMIG ETSRLPEDTL 

       130        140        150        160        170        180 
AALNAAIDKT KRNTGLILNF ALNYGGRAEI TSAVRFIAQD VLDAKLNPGD ITEDLIANYL 

       190        200        210        220        230        240 
MTDHLPYLYR DPDLIIRTSG ELRLSNFLPW QSAYSEFYFT PVLWPDFKKA ELLKAIADYN 


HRQRRFGKV

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References

[1]"Molecular genetic anatomy of inter- and intraserotype variation in the human bacterial pathogen group A Streptococcus."
Beres S.B., Richter E.W., Nagiec M.J., Sumby P., Porcella S.F., DeLeo F.R., Musser J.M.
Proc. Natl. Acad. Sci. U.S.A. 103:7059-7064(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: MGAS2096.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000261 Genomic DNA. Translation: ABF36751.1.
RefSeqYP_601295.1. NC_008023.1.

3D structure databases

ProteinModelPortalQ1J9R0.
ModBaseSearch...

Protein-protein interaction databases

STRING370553.MGAS2096_Spy1699.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABF36751; ABF36751; MGAS2096_Spy1699.
GeneID4065056.
KEGGspj:MGAS2096_Spy1699.
PATRIC19733975. VBIStrPyo133020_1749.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0020.
HOGENOMHOG000006056.
KOK00806.
OMAIAYSELF.
ProtClustDBPRK14830.

Family and domain databases

Gene3D3.40.1180.10. 1 hit.
HAMAPMF_01139. UppS.
InterProIPR001441. UPP_synth-like.
IPR018520. UPP_synth-like_CS.
[Graphical view]
PANTHERPTHR10291. PTHR10291. 1 hit.
PfamPF01255. Prenyltransf. 1 hit.
[Graphical view]
SUPFAMSSF64005. UPP_synth. 1 hit.
TIGRFAMsTIGR00055. uppS. 1 hit.
PROSITEPS01066. UPP_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ1J9R0_STRPB
AccessionPrimary (citable) accession number: Q1J9R0
Entry history
Integrated into UniProtKB/TrEMBL: June 13, 2006
Last sequence update: June 13, 2006
Last modified: May 1, 2013
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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