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Q1J8N2

- G6PI_STRPF

UniProt

Q1J8N2 - G6PI_STRPF

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Protein

Glucose-6-phosphate isomerase

Gene
pgi, MGAS10750_Spy0179
Organism
Streptococcus pyogenes serotype M4 (strain MGAS10750)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei291 – 2911Proton donor By similarity
Active sitei312 – 3121 By similarity
Active sitei426 – 4261 By similarity

GO - Molecular functioni

  1. glucose-6-phosphate isomerase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. gluconeogenesis Source: UniProtKB-HAMAP
  2. glycolytic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Gluconeogenesis, Glycolysis

Enzyme and pathway databases

BioCyciSPYO370554:GI3S-225-MONOMER.
UniPathwayiUPA00109; UER00181.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomerase (EC:5.3.1.9)
Short name:
GPI
Alternative name(s):
Phosphoglucose isomerase
Short name:
PGI
Phosphohexose isomerase
Short name:
PHI
Gene namesi
Name:pgi
Ordered Locus Names:MGAS10750_Spy0179
OrganismiStreptococcus pyogenes serotype M4 (strain MGAS10750)
Taxonomic identifieri370554 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000002434: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 449449Glucose-6-phosphate isomeraseUniRule annotationPRO_0000252653Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi370554.MGAS10750_Spy0179.

Structurei

3D structure databases

ProteinModelPortaliQ1J8N2.
SMRiQ1J8N2. Positions 3-449.

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.

Phylogenomic databases

eggNOGiCOG0166.
HOGENOMiHOG000100403.
KOiK01810.
OrthoDBiEOG64R61J.

Family and domain databases

HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1J8N2-1 [UniParc]FASTAAdd to Basket

« Hide

MSHITFDYSK VLESFAGQHE IDFLQGQVTE ADKLLREGTG PGSDFLGWLD    50
LPENYDKDEF ARILTAAEKI KSDSEVLVVI GIGGSYLGAK AAIDFLNHHF 100
ANLQTAKERK APQILYAGNS ISSTYLADLV EYVQDKEFSV NVISKSGTTT 150
EPAIAFRVFK ELLVKKYGQE EANKRIYATT DKVKGAVKVE ADANNWETFV 200
VPDNVGGRFS VLTAVGLLPI AASGADITAL MEGANAARKD LSSDKISENI 250
AYQYAAVRNV LYRKGYITEI LANYEPSLQY FGEWWKQLAG ESEGKDQKGI 300
YPTSANFSTD LHSLGQFIQE GYRNLFETVI RVDKPRKNVI IPELAEDLDG 350
LGYLQGKDVD FVNKKATDGV LLAHTDGGVP NMFVTLPAQD EFTLGYTIYF 400
FELAIAVSGY MNAVNPFDQP GVEAYKRNMF ALLGKPGFEE LSAELNARL 449
Length:449
Mass (Da):49,541
Last modified:October 17, 2006 - v2
Checksum:i125735131B6FC88B
GO

Sequence cautioni

The sequence ABF37129.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000262 Genomic DNA. Translation: ABF37129.1. Different initiation.
RefSeqiYP_601673.1. NC_008024.1.

Genome annotation databases

EnsemblBacteriaiABF37129; ABF37129; MGAS10750_Spy0179.
GeneIDi4068253.
KEGGispi:MGAS10750_Spy0179.
PATRICi19726548. VBIStrPyo25933_0181.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000262 Genomic DNA. Translation: ABF37129.1 . Different initiation.
RefSeqi YP_601673.1. NC_008024.1.

3D structure databases

ProteinModelPortali Q1J8N2.
SMRi Q1J8N2. Positions 3-449.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 370554.MGAS10750_Spy0179.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABF37129 ; ABF37129 ; MGAS10750_Spy0179 .
GeneIDi 4068253.
KEGGi spi:MGAS10750_Spy0179.
PATRICi 19726548. VBIStrPyo25933_0181.

Phylogenomic databases

eggNOGi COG0166.
HOGENOMi HOG000100403.
KOi K01810.
OrthoDBi EOG64R61J.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00181 .
BioCyci SPYO370554:GI3S-225-MONOMER.

Family and domain databases

HAMAPi MF_00473. G6P_isomerase.
InterProi IPR001672. G6P_Isomerase.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view ]
PANTHERi PTHR11469. PTHR11469. 1 hit.
Pfami PF00342. PGI. 1 hit.
[Graphical view ]
PRINTSi PR00662. G6PISOMERASE.
PROSITEi PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular genetic anatomy of inter- and intraserotype variation in the human bacterial pathogen group A Streptococcus."
    Beres S.B., Richter E.W., Nagiec M.J., Sumby P., Porcella S.F., DeLeo F.R., Musser J.M.
    Proc. Natl. Acad. Sci. U.S.A. 103:7059-7064(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MGAS10750.

Entry informationi

Entry nameiG6PI_STRPF
AccessioniPrimary (citable) accession number: Q1J8N2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: October 17, 2006
Last modified: June 11, 2014
This is version 49 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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