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Q1J8N2 (G6PI_STRPF) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glucose-6-phosphate isomerase

Short name=GPI
EC=5.3.1.9
Alternative name(s):
Phosphoglucose isomerase
Short name=PGI
Phosphohexose isomerase
Short name=PHI
Gene names
Name:pgi
Ordered Locus Names:MGAS10750_Spy0179
OrganismStreptococcus pyogenes serotype M4 (strain MGAS10750) [Complete proteome] [HAMAP]
Taxonomic identifier370554 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Protein attributes

Sequence length449 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

D-glucose 6-phosphate = D-fructose 6-phosphate. HAMAP-Rule MF_00473

Pathway

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. HAMAP-Rule MF_00473

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00473.

Sequence similarities

Belongs to the GPI family.

Sequence caution

The sequence ABF37129.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processGluconeogenesis
Glycolysis
   Cellular componentCytoplasm
   Molecular functionIsomerase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processgluconeogenesis

Inferred from electronic annotation. Source: UniProtKB-HAMAP

glycolytic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionglucose-6-phosphate isomerase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 449449Glucose-6-phosphate isomerase HAMAP-Rule MF_00473
PRO_0000252653

Sites

Active site2911Proton donor By similarity
Active site3121 By similarity
Active site4261 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q1J8N2 [UniParc].

Last modified October 17, 2006. Version 2.
Checksum: 125735131B6FC88B

FASTA44949,541
        10         20         30         40         50         60 
MSHITFDYSK VLESFAGQHE IDFLQGQVTE ADKLLREGTG PGSDFLGWLD LPENYDKDEF 

        70         80         90        100        110        120 
ARILTAAEKI KSDSEVLVVI GIGGSYLGAK AAIDFLNHHF ANLQTAKERK APQILYAGNS 

       130        140        150        160        170        180 
ISSTYLADLV EYVQDKEFSV NVISKSGTTT EPAIAFRVFK ELLVKKYGQE EANKRIYATT 

       190        200        210        220        230        240 
DKVKGAVKVE ADANNWETFV VPDNVGGRFS VLTAVGLLPI AASGADITAL MEGANAARKD 

       250        260        270        280        290        300 
LSSDKISENI AYQYAAVRNV LYRKGYITEI LANYEPSLQY FGEWWKQLAG ESEGKDQKGI 

       310        320        330        340        350        360 
YPTSANFSTD LHSLGQFIQE GYRNLFETVI RVDKPRKNVI IPELAEDLDG LGYLQGKDVD 

       370        380        390        400        410        420 
FVNKKATDGV LLAHTDGGVP NMFVTLPAQD EFTLGYTIYF FELAIAVSGY MNAVNPFDQP 

       430        440 
GVEAYKRNMF ALLGKPGFEE LSAELNARL 

« Hide

References

[1]"Molecular genetic anatomy of inter- and intraserotype variation in the human bacterial pathogen group A Streptococcus."
Beres S.B., Richter E.W., Nagiec M.J., Sumby P., Porcella S.F., DeLeo F.R., Musser J.M.
Proc. Natl. Acad. Sci. U.S.A. 103:7059-7064(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: MGAS10750.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000262 Genomic DNA. Translation: ABF37129.1. Different initiation.
RefSeqYP_601673.1. NC_008024.1.

3D structure databases

ProteinModelPortalQ1J8N2.
SMRQ1J8N2. Positions 3-449.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING370554.MGAS10750_Spy0179.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABF37129; ABF37129; MGAS10750_Spy0179.
GeneID4068253.
KEGGspi:MGAS10750_Spy0179.
PATRIC19726548. VBIStrPyo25933_0181.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0166.
HOGENOMHOG000100403.
KOK01810.
OrthoDBEOG64R61J.

Enzyme and pathway databases

BioCycSPYO370554:GI3S-225-MONOMER.
UniPathwayUPA00109; UER00181.

Family and domain databases

HAMAPMF_00473. G6P_isomerase.
InterProIPR001672. G6P_Isomerase.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERPTHR11469. PTHR11469. 1 hit.
PfamPF00342. PGI. 1 hit.
[Graphical view]
PRINTSPR00662. G6PISOMERASE.
PROSITEPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameG6PI_STRPF
AccessionPrimary (citable) accession number: Q1J8N2
Entry history
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: October 17, 2006
Last modified: June 11, 2014
This is version 49 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways