Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q1J8N2

- G6PI_STRPF

UniProt

Q1J8N2 - G6PI_STRPF

Protein

Glucose-6-phosphate isomerase

Gene

pgi

Organism
Streptococcus pyogenes serotype M4 (strain MGAS10750)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 50 (01 Oct 2014)
      Sequence version 2 (17 Oct 2006)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalytic activityi

    D-glucose 6-phosphate = D-fructose 6-phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei291 – 2911Proton donorUniRule annotation
    Active sitei312 – 3121UniRule annotation
    Active sitei426 – 4261UniRule annotation

    GO - Molecular functioni

    1. glucose-6-phosphate isomerase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. gluconeogenesis Source: UniProtKB-HAMAP
    2. glycolytic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Gluconeogenesis, Glycolysis

    Enzyme and pathway databases

    BioCyciSPYO370554:GI3S-225-MONOMER.
    UniPathwayiUPA00109; UER00181.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glucose-6-phosphate isomeraseUniRule annotation (EC:5.3.1.9UniRule annotation)
    Short name:
    GPIUniRule annotation
    Alternative name(s):
    Phosphoglucose isomeraseUniRule annotation
    Short name:
    PGIUniRule annotation
    Phosphohexose isomeraseUniRule annotation
    Short name:
    PHIUniRule annotation
    Gene namesi
    Name:pgiUniRule annotation
    Ordered Locus Names:MGAS10750_Spy0179
    OrganismiStreptococcus pyogenes serotype M4 (strain MGAS10750)
    Taxonomic identifieri370554 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
    ProteomesiUP000002434: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 449449Glucose-6-phosphate isomerasePRO_0000252653Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi370554.MGAS10750_Spy0179.

    Structurei

    3D structure databases

    ProteinModelPortaliQ1J8N2.
    SMRiQ1J8N2. Positions 3-449.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GPI family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0166.
    HOGENOMiHOG000100403.
    KOiK01810.
    OrthoDBiEOG64R61J.

    Family and domain databases

    HAMAPiMF_00473. G6P_isomerase.
    InterProiIPR001672. G6P_Isomerase.
    IPR018189. Phosphoglucose_isomerase_CS.
    [Graphical view]
    PANTHERiPTHR11469. PTHR11469. 1 hit.
    PfamiPF00342. PGI. 1 hit.
    [Graphical view]
    PRINTSiPR00662. G6PISOMERASE.
    PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
    PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
    PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q1J8N2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSHITFDYSK VLESFAGQHE IDFLQGQVTE ADKLLREGTG PGSDFLGWLD    50
    LPENYDKDEF ARILTAAEKI KSDSEVLVVI GIGGSYLGAK AAIDFLNHHF 100
    ANLQTAKERK APQILYAGNS ISSTYLADLV EYVQDKEFSV NVISKSGTTT 150
    EPAIAFRVFK ELLVKKYGQE EANKRIYATT DKVKGAVKVE ADANNWETFV 200
    VPDNVGGRFS VLTAVGLLPI AASGADITAL MEGANAARKD LSSDKISENI 250
    AYQYAAVRNV LYRKGYITEI LANYEPSLQY FGEWWKQLAG ESEGKDQKGI 300
    YPTSANFSTD LHSLGQFIQE GYRNLFETVI RVDKPRKNVI IPELAEDLDG 350
    LGYLQGKDVD FVNKKATDGV LLAHTDGGVP NMFVTLPAQD EFTLGYTIYF 400
    FELAIAVSGY MNAVNPFDQP GVEAYKRNMF ALLGKPGFEE LSAELNARL 449
    Length:449
    Mass (Da):49,541
    Last modified:October 17, 2006 - v2
    Checksum:i125735131B6FC88B
    GO

    Sequence cautioni

    The sequence ABF37129.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000262 Genomic DNA. Translation: ABF37129.1. Different initiation.
    RefSeqiYP_601673.1. NC_008024.1.

    Genome annotation databases

    EnsemblBacteriaiABF37129; ABF37129; MGAS10750_Spy0179.
    GeneIDi4068253.
    KEGGispi:MGAS10750_Spy0179.
    PATRICi19726548. VBIStrPyo25933_0181.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000262 Genomic DNA. Translation: ABF37129.1 . Different initiation.
    RefSeqi YP_601673.1. NC_008024.1.

    3D structure databases

    ProteinModelPortali Q1J8N2.
    SMRi Q1J8N2. Positions 3-449.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 370554.MGAS10750_Spy0179.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABF37129 ; ABF37129 ; MGAS10750_Spy0179 .
    GeneIDi 4068253.
    KEGGi spi:MGAS10750_Spy0179.
    PATRICi 19726548. VBIStrPyo25933_0181.

    Phylogenomic databases

    eggNOGi COG0166.
    HOGENOMi HOG000100403.
    KOi K01810.
    OrthoDBi EOG64R61J.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00181 .
    BioCyci SPYO370554:GI3S-225-MONOMER.

    Family and domain databases

    HAMAPi MF_00473. G6P_isomerase.
    InterProi IPR001672. G6P_Isomerase.
    IPR018189. Phosphoglucose_isomerase_CS.
    [Graphical view ]
    PANTHERi PTHR11469. PTHR11469. 1 hit.
    Pfami PF00342. PGI. 1 hit.
    [Graphical view ]
    PRINTSi PR00662. G6PISOMERASE.
    PROSITEi PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
    PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
    PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular genetic anatomy of inter- and intraserotype variation in the human bacterial pathogen group A Streptococcus."
      Beres S.B., Richter E.W., Nagiec M.J., Sumby P., Porcella S.F., DeLeo F.R., Musser J.M.
      Proc. Natl. Acad. Sci. U.S.A. 103:7059-7064(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MGAS10750.

    Entry informationi

    Entry nameiG6PI_STRPF
    AccessioniPrimary (citable) accession number: Q1J8N2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 17, 2006
    Last sequence update: October 17, 2006
    Last modified: October 1, 2014
    This is version 50 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3