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Q1J7N7

- Q1J7N7_STRPF

UniProt

Q1J7N7 - Q1J7N7_STRPF

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Protein
Phosphoenolpyruvate carboxylase
Gene
ppc, MGAS10750_Spy0524
Organism
Streptococcus pyogenes serotype M4 (strain MGAS10750)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle By similarity.UniRule annotation

Catalytic activityi

Phosphate + oxaloacetate = H2O + phosphoenolpyruvate + HCO3-.UniRule annotationSAAS annotations

Cofactori

Magnesium By similarity.UniRule annotationSAAS annotations

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei155 – 1551 By similarityUniRule annotation
Active sitei600 – 6001 By similarityUniRule annotation

GO - Molecular functioni

  1. magnesium ion binding Source: UniProtKB-HAMAP
  2. phosphoenolpyruvate carboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbon fixation Source: UniProtKB-HAMAP
  2. oxaloacetate metabolic process Source: UniProtKB-HAMAP
  3. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotationSAAS annotationsImported

Keywords - Biological processi

Carbon dioxide fixationUniRule annotationSAAS annotations

Keywords - Ligandi

MagnesiumUniRule annotationSAAS annotations, PyruvateImported

Enzyme and pathway databases

BioCyciSPYO370554:GI3S-575-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxylaseUniRule annotation (EC:4.1.1.31UniRule annotation)
Short name:
PEPCUniRule annotation
Short name:
PEPCaseUniRule annotation
Gene namesi
Name:ppcUniRule annotationImported
Ordered Locus Names:MGAS10750_Spy0524Imported
OrganismiStreptococcus pyogenes serotype M4 (strain MGAS10750)Imported
Taxonomic identifieri370554 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000002434: Chromosome

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi370554.MGAS10750_Spy0524.

Structurei

3D structure databases

ProteinModelPortaliQ1J7N7.

Family & Domainsi

Sequence similaritiesi

Belongs to the PEPCase type 1 family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2352.
HOGENOMiHOG000238647.
KOiK01595.
OMAiGIQITIN.
OrthoDBiEOG6TJ7T8.

Family and domain databases

HAMAPiMF_00595. PEPcase_type1.
InterProiIPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF00311. PEPcase. 1 hit.
[Graphical view]
PRINTSiPR00150. PEPCARBXLASE.
SUPFAMiSSF51621. SSF51621. 1 hit.
PROSITEiPS00781. PEPCASE_1. 1 hit.
PS00393. PEPCASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1J7N7-1 [UniParc]FASTAAdd to Basket

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MVKSGMIEET SKEGDGHLPL KKLESSNNQT IIAEEVALLK EMLENITRRM    50
IGDDAFTVIE SIMVLSEKQD YIELEKVVAN ISNQEMEVIS RYFSILPLLI 100
NISEDVDLAY EINHQNNTDT DYLGKLALTI KDLAGKDNGK DILEQVNVVP 150
VLTAHPTQVQ RKTILELTTH IHKLLRKYRD AKTGVINLEK WRQELYRYIE 200
MIMQTDIIRE KKLQVKNEIK NVMQYYDGSL IQAVTKLTTE YKNLAQKHGL 250
ELDNPKPITM GMWIGGDRDG NPFVTAETLC LSATVQSEVI LNYYIDKLAA 300
LYRTFSLSST LVQPNSEVER LASLSQDQSI YRGNEPYRRA FHYIQSRLKQ 350
TQIQLTNQPA ARMSSSVGLN TSAWSSPASL ENPILAYDSP VDFKADLKAI 400
EQSLLDNGNF ALIEGDLREV MQAVDIFGFF LASIDMRQDS SVQEACVAEL 450
LKGANIVDDY SSLSETEKCD VLLQQLMEEP RTLSSAAVAK SDLLEKELAI 500
YTTARELKDK LGEEVIKQHI ISHTESVSDM FELAIMLKEV GLVDQQRARV 550
QIVPLFETIE DLDNARDIMA AYLSHDIVKS WIATNRNYQE IMLGYSDSNK 600
DGGYLASGWT LYKAQNELTA IGEEHGVKIT FFHGRGGTVG RGGGPSYDAI 650
TSQPFGSIKD RIRLTEQGEI IENKYGNKDV AYYHLEMLIS ASINRMVTQM 700
ITDPNEIDSF REIMDSIVAD SNTIYRKLVF DNPHFYDYFF EASPIKEVSS 750
LNIGSRPAAR KTITEITGLR AIPWVFSWSQ NRIMFPGWYG VGSAFKRYID 800
RAQGNLERLQ HMYQTWPFFH SLLSNVDMVL SKSNMNIAFQ YAQLAESQDV 850
RDVFYEILDE WQLTKNVILA IQDHDDLLED NPSLKHSLKS RLPYFNVLNY 900
IQIELIKRWR NNQLDENDEK LIHTTINGIA TGLRNSG 937
Length:937
Mass (Da):106,588
Last modified:June 13, 2006 - v1
Checksum:i3676B398621CF778
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000262 Genomic DNA. Translation: ABF37474.1.
RefSeqiYP_602018.1. NC_008024.1.

Genome annotation databases

EnsemblBacteriaiABF37474; ABF37474; MGAS10750_Spy0524.
GeneIDi4068046.
KEGGispi:MGAS10750_Spy0524.
PATRICi19727289. VBIStrPyo25933_0544.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000262 Genomic DNA. Translation: ABF37474.1 .
RefSeqi YP_602018.1. NC_008024.1.

3D structure databases

ProteinModelPortali Q1J7N7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 370554.MGAS10750_Spy0524.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABF37474 ; ABF37474 ; MGAS10750_Spy0524 .
GeneIDi 4068046.
KEGGi spi:MGAS10750_Spy0524.
PATRICi 19727289. VBIStrPyo25933_0544.

Phylogenomic databases

eggNOGi COG2352.
HOGENOMi HOG000238647.
KOi K01595.
OMAi GIQITIN.
OrthoDBi EOG6TJ7T8.

Enzyme and pathway databases

BioCyci SPYO370554:GI3S-575-MONOMER.

Family and domain databases

HAMAPi MF_00595. PEPcase_type1.
InterProi IPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view ]
Pfami PF00311. PEPcase. 1 hit.
[Graphical view ]
PRINTSi PR00150. PEPCARBXLASE.
SUPFAMi SSF51621. SSF51621. 1 hit.
PROSITEi PS00781. PEPCASE_1. 1 hit.
PS00393. PEPCASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular genetic anatomy of inter- and intraserotype variation in the human bacterial pathogen group A Streptococcus."
    Beres S.B., Richter E.W., Nagiec M.J., Sumby P., Porcella S.F., DeLeo F.R., Musser J.M.
    Proc. Natl. Acad. Sci. U.S.A. 103:7059-7064(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MGAS10750Imported.

Entry informationi

Entry nameiQ1J7N7_STRPF
AccessioniPrimary (citable) accession number: Q1J7N7
Entry historyi
Integrated into UniProtKB/TrEMBL: June 13, 2006
Last sequence update: June 13, 2006
Last modified: June 11, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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