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Q1J7N4 (EFTU_STRPF) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Elongation factor Tu
Short name=EF-Tu
Gene names
Name:tuf
Ordered Locus Names:MGAS10750_Spy0527
OrganismStreptococcus pyogenes serotype M4 (strain MGAS10750) [Complete proteome] [HAMAP]
Taxonomic identifier370554 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacilli › Lactobacillales › Streptococcaceae › Streptococcus ›

Protein attributes

Sequence length398 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis By similarity. HAMAP-Rule MF_00118

Subunit structure

Monomer By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the GTP-binding elongation factor family. EF-Tu/EF-1A subfamily.

Sequence caution

The sequence ABF37477.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandGTP-binding
Nucleotide-binding
   Molecular functionElongation factor
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processGTP catabolic process

Inferred from electronic annotation. Source: GOC

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionGTP binding

Inferred from electronic annotation. Source: HAMAP

GTPase activity

Inferred from electronic annotation. Source: InterPro

translation elongation factor activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 398398Elongation factor Tu HAMAP-Rule MF_00118
PRO_0000337554

Regions

Nucleotide binding19 – 268GTP By similarity
Nucleotide binding84 – 885GTP By similarity
Nucleotide binding139 – 1424GTP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q1J7N4 [UniParc].

Last modified May 20, 2008. Version 2.
Checksum: 95FCB3D69013C6FA

FASTA39843,826
        10         20         30         40         50         60 
MAKEKYDRSK PHVNIGTIGH VDHGKTTLTA AITTVLARRL PSSVNQPKDY ASIDAAPEER 

        70         80         90        100        110        120 
ERGITINTAH VEYETATRHY AHIDAPGHAD YVKNMITGAA QMDGAILVVA STDGPMPQTR 

       130        140        150        160        170        180 
EHILLSRQVG VKHLIVFMNK VDLVDDEELL ELVEMEIRDL LSEYDFPGDD LPVIQGSALK 

       190        200        210        220        230        240 
ALEGDTKFED IIMELMDTVD SYIPEPERDT DKPLLLPVED VFSITGRGTV ASGRIDRGTV 

       250        260        270        280        290        300 
RVNDEIEIVG IKEETKKAVV TGVEMFRKQL DEGLAGDNVG ILLRGVQRDE IERGQVIAKP 

       310        320        330        340        350        360 
GSINPHTKFK GEVYILSKDE GGRHTPFFNN YRPQFYFRTT DVTGSIELPA GTEMVMPGDN 

       370        380        390 
VTINVELIHP IAVEQGTTFS IREGGRTVGS GIVSEIEA

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References

[1]"Molecular genetic anatomy of inter- and intraserotype variation in the human bacterial pathogen group A Streptococcus."
Beres S.B., Richter E.W., Nagiec M.J., Sumby P., Porcella S.F., DeLeo F.R., Musser J.M.
Proc. Natl. Acad. Sci. U.S.A. 103:7059-7064(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: MGAS10750.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000262 Genomic DNA. Translation: ABF37477.1. Different initiation.
RefSeqYP_602021.2. NC_008024.1.

3D structure databases

ProteinModelPortalQ1J7N4.
SMRQ1J7N4. Positions 2-396.
ModBaseSearch...

Protein-protein interaction databases

STRING370554.MGAS10750_Spy0527.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABF37477; ABF37477; MGAS10750_Spy0527.
GeneID4068049.
KEGGspi:MGAS10750_Spy0527.
PATRIC19727295. VBIStrPyo25933_0547.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0050.
HOGENOMHOG000229290.
KOK02358.
ProtClustDBPRK12736.

Family and domain databases

HAMAPMF_00118_B. EF_Tu_B.
InterProIPR000795. EF_GTP-bd_dom.
IPR005225. Small_GTP-bd_dom.
IPR009001. Transl_elong_EF1A/Init_IF2_C.
IPR004161. Transl_elong_EFTu/EF1A_2.
IPR004541. Transl_elong_EFTu/EF1A_bac/org.
IPR004160. Transl_elong_EFTu/EF1A_C.
IPR009000. Transl_elong_init/rib_B-barrel.
[Graphical view]
PfamPF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
PF03143. GTP_EFTU_D3. 1 hit.
[Graphical view]
PRINTSPR00315. ELONGATNFCT.
SUPFAMSSF50465. Elong_init_C. 1 hit.
SSF50447. Translat_factor. 1 hit.
TIGRFAMsTIGR00485. EF-Tu. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEPS00301. EFACTOR_GTP. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameEFTU_STRPF
AccessionPrimary (citable) accession number: Q1J7N4
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: May 1, 2013
This is version 52 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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