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Q1J7N4

- EFTU_STRPF

UniProt

Q1J7N4 - EFTU_STRPF

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Protein

Elongation factor Tu

Gene

tuf

Organism
Streptococcus pyogenes serotype M4 (strain MGAS10750)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi19 – 268GTPUniRule annotation
Nucleotide bindingi84 – 885GTPUniRule annotation
Nucleotide bindingi139 – 1424GTPUniRule annotation

GO - Molecular functioni

  1. GTPase activity Source: InterPro
  2. GTP binding Source: UniProtKB-HAMAP
  3. translation elongation factor activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Elongation factor

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSPYO370554:GI3S-578-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Elongation factor TuUniRule annotation
Short name:
EF-TuUniRule annotation
Gene namesi
Name:tufUniRule annotation
Ordered Locus Names:MGAS10750_Spy0527
OrganismiStreptococcus pyogenes serotype M4 (strain MGAS10750)
Taxonomic identifieri370554 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000002434: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 398398Elongation factor TuPRO_0000337554Add
BLAST

Proteomic databases

PRIDEiQ1J7N4.

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi370554.MGAS10750_Spy0527.

Structurei

3D structure databases

ProteinModelPortaliQ1J7N4.
SMRiQ1J7N4. Positions 2-396.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini10 – 207198tr-type GAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni19 – 268G1By similarity
Regioni63 – 675G2By similarity
Regioni84 – 874G3By similarity
Regioni139 – 1424G4By similarity
Regioni177 – 1793G5By similarity

Sequence similaritiesi

Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0050.
HOGENOMiHOG000229290.
KOiK02358.
OrthoDBiEOG6R5C6X.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00118_B. EF_Tu_B.
InterProiIPR000795. EF_GTP-bd_dom.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR009000. Transl_B-barrel.
IPR009001. Transl_elong_EF1A/Init_IF2_C.
IPR004161. Transl_elong_EFTu/EF1A_2.
IPR004541. Transl_elong_EFTu/EF1A_bac/org.
IPR004160. Transl_elong_EFTu/EF1A_C.
[Graphical view]
PfamiPF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
PF03143. GTP_EFTU_D3. 1 hit.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF50465. SSF50465. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00485. EF-Tu. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS00301. G_TR_1. 1 hit.
PS51722. G_TR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1J7N4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAKEKYDRSK PHVNIGTIGH VDHGKTTLTA AITTVLARRL PSSVNQPKDY
60 70 80 90 100
ASIDAAPEER ERGITINTAH VEYETATRHY AHIDAPGHAD YVKNMITGAA
110 120 130 140 150
QMDGAILVVA STDGPMPQTR EHILLSRQVG VKHLIVFMNK VDLVDDEELL
160 170 180 190 200
ELVEMEIRDL LSEYDFPGDD LPVIQGSALK ALEGDTKFED IIMELMDTVD
210 220 230 240 250
SYIPEPERDT DKPLLLPVED VFSITGRGTV ASGRIDRGTV RVNDEIEIVG
260 270 280 290 300
IKEETKKAVV TGVEMFRKQL DEGLAGDNVG ILLRGVQRDE IERGQVIAKP
310 320 330 340 350
GSINPHTKFK GEVYILSKDE GGRHTPFFNN YRPQFYFRTT DVTGSIELPA
360 370 380 390
GTEMVMPGDN VTINVELIHP IAVEQGTTFS IREGGRTVGS GIVSEIEA
Length:398
Mass (Da):43,826
Last modified:May 20, 2008 - v2
Checksum:i95FCB3D69013C6FA
GO

Sequence cautioni

The sequence ABF37477.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000262 Genomic DNA. Translation: ABF37477.1. Different initiation.
RefSeqiYP_602021.2. NC_008024.1.

Genome annotation databases

EnsemblBacteriaiABF37477; ABF37477; MGAS10750_Spy0527.
GeneIDi4068049.
KEGGispi:MGAS10750_Spy0527.
PATRICi19727295. VBIStrPyo25933_0547.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000262 Genomic DNA. Translation: ABF37477.1 . Different initiation.
RefSeqi YP_602021.2. NC_008024.1.

3D structure databases

ProteinModelPortali Q1J7N4.
SMRi Q1J7N4. Positions 2-396.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 370554.MGAS10750_Spy0527.

Proteomic databases

PRIDEi Q1J7N4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABF37477 ; ABF37477 ; MGAS10750_Spy0527 .
GeneIDi 4068049.
KEGGi spi:MGAS10750_Spy0527.
PATRICi 19727295. VBIStrPyo25933_0547.

Phylogenomic databases

eggNOGi COG0050.
HOGENOMi HOG000229290.
KOi K02358.
OrthoDBi EOG6R5C6X.

Enzyme and pathway databases

BioCyci SPYO370554:GI3S-578-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
HAMAPi MF_00118_B. EF_Tu_B.
InterProi IPR000795. EF_GTP-bd_dom.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR009000. Transl_B-barrel.
IPR009001. Transl_elong_EF1A/Init_IF2_C.
IPR004161. Transl_elong_EFTu/EF1A_2.
IPR004541. Transl_elong_EFTu/EF1A_bac/org.
IPR004160. Transl_elong_EFTu/EF1A_C.
[Graphical view ]
Pfami PF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
PF03143. GTP_EFTU_D3. 1 hit.
[Graphical view ]
PRINTSi PR00315. ELONGATNFCT.
SUPFAMi SSF50447. SSF50447. 1 hit.
SSF50465. SSF50465. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00485. EF-Tu. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEi PS00301. G_TR_1. 1 hit.
PS51722. G_TR_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular genetic anatomy of inter- and intraserotype variation in the human bacterial pathogen group A Streptococcus."
    Beres S.B., Richter E.W., Nagiec M.J., Sumby P., Porcella S.F., DeLeo F.R., Musser J.M.
    Proc. Natl. Acad. Sci. U.S.A. 103:7059-7064(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MGAS10750.

Entry informationi

Entry nameiEFTU_STRPF
AccessioniPrimary (citable) accession number: Q1J7N4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: October 29, 2014
This is version 62 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3