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Protein

Probable 2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A synthase

Gene

citG

Organism
Streptococcus pyogenes serotype M4 (strain MGAS10750)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 3'-dephospho-CoA = 2'-(5-triphospho-alpha-D-ribosyl)-3'-dephospho-CoA + adenine.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSPYO370554:GI3S-1102-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable 2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A synthaseUniRule annotation (EC:2.4.2.52UniRule annotation)
Short name:
2-(5''-triphosphoribosyl)-3'-dephospho-CoA synthaseUniRule annotation
Gene namesi
Name:citGUniRule annotation
Ordered Locus Names:MGAS10750_Spy1047
OrganismiStreptococcus pyogenes serotype M4 (strain MGAS10750)
Taxonomic identifieri370554 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000002434 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 294294Probable 2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A synthasePRO_0000255418Add
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the CitG/MdcB family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000258582.
KOiK05966.
OMAiIHRGGIK.
OrthoDBiEOG6WHNRS.

Family and domain databases

HAMAPiMF_00397. CitG.
InterProiIPR002736. CitG.
IPR017551. TriPribosyl-deP-CoA_syn_CitG.
[Graphical view]
PfamiPF01874. CitG. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03125. citrate_citG. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1J6I6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKAVLTSIS QLALKALLYE VSLSPKPGLV DRFDNGAHDD MSFMTFIDSM
60 70 80 90 100
IALSPFFQAY IETGFAYAKE EPLLLFNRLR QLGQKAEETM FCATQGINTH
110 120 130 140 150
KGLNFSMALL LGATGAYLAR TPHLMTDLGR FSKEDTLAIC RLVKPMTAHL
160 170 180 190 200
IQTDLGHLNT KKEFTYGEQL FVTYGIKGPR GEASEGFTTL TDHALPYFRQ
210 220 230 240 250
MISQNDPETS QLRLLVYLMS IVEDGNLIHR GGIEAWKGVK ADMRLLLQQD
260 270 280 290
LSTTDLRLAL SSYNQCLINQ HLSPGGAADL LALTFYFAFL EKLL
Length:294
Mass (Da):32,788
Last modified:June 13, 2006 - v1
Checksum:i84F51E504FA53A84
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000262 Genomic DNA. Translation: ABF37997.1.
RefSeqiWP_011054506.1. NC_008024.1.

Genome annotation databases

EnsemblBacteriaiABF37997; ABF37997; MGAS10750_Spy1047.
KEGGispi:MGAS10750_Spy1047.
PATRICi19728359. VBIStrPyo25933_1074.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000262 Genomic DNA. Translation: ABF37997.1.
RefSeqiWP_011054506.1. NC_008024.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABF37997; ABF37997; MGAS10750_Spy1047.
KEGGispi:MGAS10750_Spy1047.
PATRICi19728359. VBIStrPyo25933_1074.

Phylogenomic databases

HOGENOMiHOG000258582.
KOiK05966.
OMAiIHRGGIK.
OrthoDBiEOG6WHNRS.

Enzyme and pathway databases

BioCyciSPYO370554:GI3S-1102-MONOMER.

Family and domain databases

HAMAPiMF_00397. CitG.
InterProiIPR002736. CitG.
IPR017551. TriPribosyl-deP-CoA_syn_CitG.
[Graphical view]
PfamiPF01874. CitG. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03125. citrate_citG. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Molecular genetic anatomy of inter- and intraserotype variation in the human bacterial pathogen group A Streptococcus."
    Beres S.B., Richter E.W., Nagiec M.J., Sumby P., Porcella S.F., DeLeo F.R., Musser J.M.
    Proc. Natl. Acad. Sci. U.S.A. 103:7059-7064(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MGAS10750.

Entry informationi

Entry nameiCITG_STRPF
AccessioniPrimary (citable) accession number: Q1J6I6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: June 13, 2006
Last modified: November 11, 2015
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.