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Q1J4N2

- PNP_STRPF

UniProt

Q1J4N2 - PNP_STRPF

Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Streptococcus pyogenes serotype M4 (strain MGAS10750)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 1 (13 Jun 2006)
      Previous versions | rss
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    Functioni

    Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

    Catalytic activityi

    RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

    Cofactori

    Magnesium.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi489 – 4891MagnesiumUniRule annotation
    Metal bindingi495 – 4951MagnesiumUniRule annotation

    GO - Molecular functioni

    1. 3'-5'-exoribonuclease activity Source: InterPro
    2. magnesium ion binding Source: UniProtKB-HAMAP
    3. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
    4. RNA binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. mRNA catabolic process Source: UniProtKB-HAMAP
    2. RNA processing Source: InterPro

    Keywords - Molecular functioni

    Nucleotidyltransferase, Transferase

    Keywords - Ligandi

    Magnesium, Metal-binding, RNA-binding

    Enzyme and pathway databases

    BioCyciSPYO370554:GI3S-1829-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
    Alternative name(s):
    Polynucleotide phosphorylaseUniRule annotation
    Short name:
    PNPaseUniRule annotation
    Gene namesi
    Name:pnpUniRule annotation
    Ordered Locus Names:MGAS10750_Spy1754
    OrganismiStreptococcus pyogenes serotype M4 (strain MGAS10750)
    Taxonomic identifieri370554 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
    ProteomesiUP000002434: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 710710Polyribonucleotide nucleotidyltransferasePRO_0000329879Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi370554.MGAS10750_Spy1754.

    Structurei

    3D structure databases

    ProteinModelPortaliQ1J4N2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini556 – 61560KHUniRule annotationAdd
    BLAST
    Domaini625 – 69369S1 motifUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation
    Contains 1 KH domain.UniRule annotation
    Contains 1 S1 motif domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1185.
    HOGENOMiHOG000218326.
    KOiK00962.
    OMAiISMEDTH.
    OrthoDBiEOG6WT8CC.

    Family and domain databases

    Gene3Di1.10.10.400. 1 hit.
    2.40.50.140. 1 hit.
    3.30.1370.10. 1 hit.
    3.30.230.70. 2 hits.
    HAMAPiMF_01595. PNPase.
    InterProiIPR001247. ExoRNase_PH_dom1.
    IPR015847. ExoRNase_PH_dom2.
    IPR004087. KH_dom.
    IPR004088. KH_dom_type_1.
    IPR012340. NA-bd_OB-fold.
    IPR012162. PNPase.
    IPR027408. PNPase/RNase_PH_dom.
    IPR015848. PNPase_PH_RNA-bd_bac/org-type.
    IPR003029. Rbsml_prot_S1_RNA-bd_dom.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR022967. RNA-binding_domain_S1.
    [Graphical view]
    PANTHERiPTHR11252. PTHR11252. 1 hit.
    PfamiPF00013. KH_1. 1 hit.
    PF03726. PNPase. 1 hit.
    PF01138. RNase_PH. 2 hits.
    PF03725. RNase_PH_C. 2 hits.
    PF00575. S1. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005499. PNPase. 1 hit.
    SMARTiSM00322. KH. 1 hit.
    SM00316. S1. 1 hit.
    [Graphical view]
    SUPFAMiSSF46915. SSF46915. 1 hit.
    SSF50249. SSF50249. 1 hit.
    SSF54211. SSF54211. 2 hits.
    SSF54791. SSF54791. 1 hit.
    SSF55666. SSF55666. 2 hits.
    TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
    PROSITEiPS50084. KH_TYPE_1. 1 hit.
    PS50126. S1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q1J4N2-1 [UniParc]FASTAAdd to Basket

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    MSKQTFTTTF AGKPLVVEVG QVAKQANGAT VVRYGDSTVL TAAVMSKKMA    50
    TGDFFPLQVN YEEKMYAAGK FPGGFMKREG RPSTDATLTA RLIDRPIRPM 100
    FAEGFRNEVQ VINTVLSYDE NASAPVAAMF GSSLALSISD IPFNGPIAGV 150
    QVGYIDGEFI INPDKEQMEA SLLELTVAGS KEAINMVESG AKELSEDIML 200
    EALLKGHQAI QELIAFQEQI VAVVGKEKAE VELLQVDADL QADIVAKYNA 250
    QLQKAVQVEE KKAREAATEA VKEMVKAEYE ERYAEDENLA TIMRDVAEIL 300
    EQMEHAEVRR LITEDKIRPD GRKIDEIRPL DAVVDFLPKV HGSGLFTRGQ 350
    TQALSVLTLA PMGETQIIDG LAPEYKKRFL HHYNFPQYSV GETGRYGAAG 400
    RREIGHGALG ERALEQVLPS LEEFPYAIRL VAEVLESNGS SSQASICAGT 450
    LALMAGGVPI KAPVAGIAMG LISDGTNYTV LTDIQGLEDH FGDMDFKVAG 500
    TREGITALQM DIKIAGITPQ ILEEALAQAK KARFEILDVI EATIAEPRPE 550
    LAPTAPKIDT IKIDVDKIKV VIGKGGETID KIIAETGVKI DIDDEGNVSI 600
    YSSDQAAIDR TKEIIAGLVR EAKVGEVYHA KVIRIEKFGA FVNLFDKTDA 650
    LVHISEIAWT RTANVSDVLE VGEDVDVKVI KIDEKGRVDA SMKALIPRPP 700
    KPEKKEEKHD 710
    Length:710
    Mass (Da):77,320
    Last modified:June 13, 2006 - v1
    Checksum:iB62A4C7A5BA7E0A0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000262 Genomic DNA. Translation: ABF38704.1.
    RefSeqiYP_603248.1. NC_008024.1.

    Genome annotation databases

    EnsemblBacteriaiABF38704; ABF38704; MGAS10750_Spy1754.
    GeneIDi4067314.
    KEGGispi:MGAS10750_Spy1754.
    PATRICi19729850. VBIStrPyo25933_1799.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000262 Genomic DNA. Translation: ABF38704.1 .
    RefSeqi YP_603248.1. NC_008024.1.

    3D structure databases

    ProteinModelPortali Q1J4N2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 370554.MGAS10750_Spy1754.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABF38704 ; ABF38704 ; MGAS10750_Spy1754 .
    GeneIDi 4067314.
    KEGGi spi:MGAS10750_Spy1754.
    PATRICi 19729850. VBIStrPyo25933_1799.

    Phylogenomic databases

    eggNOGi COG1185.
    HOGENOMi HOG000218326.
    KOi K00962.
    OMAi ISMEDTH.
    OrthoDBi EOG6WT8CC.

    Enzyme and pathway databases

    BioCyci SPYO370554:GI3S-1829-MONOMER.

    Family and domain databases

    Gene3Di 1.10.10.400. 1 hit.
    2.40.50.140. 1 hit.
    3.30.1370.10. 1 hit.
    3.30.230.70. 2 hits.
    HAMAPi MF_01595. PNPase.
    InterProi IPR001247. ExoRNase_PH_dom1.
    IPR015847. ExoRNase_PH_dom2.
    IPR004087. KH_dom.
    IPR004088. KH_dom_type_1.
    IPR012340. NA-bd_OB-fold.
    IPR012162. PNPase.
    IPR027408. PNPase/RNase_PH_dom.
    IPR015848. PNPase_PH_RNA-bd_bac/org-type.
    IPR003029. Rbsml_prot_S1_RNA-bd_dom.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR022967. RNA-binding_domain_S1.
    [Graphical view ]
    PANTHERi PTHR11252. PTHR11252. 1 hit.
    Pfami PF00013. KH_1. 1 hit.
    PF03726. PNPase. 1 hit.
    PF01138. RNase_PH. 2 hits.
    PF03725. RNase_PH_C. 2 hits.
    PF00575. S1. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005499. PNPase. 1 hit.
    SMARTi SM00322. KH. 1 hit.
    SM00316. S1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46915. SSF46915. 1 hit.
    SSF50249. SSF50249. 1 hit.
    SSF54211. SSF54211. 2 hits.
    SSF54791. SSF54791. 1 hit.
    SSF55666. SSF55666. 2 hits.
    TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
    PROSITEi PS50084. KH_TYPE_1. 1 hit.
    PS50126. S1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular genetic anatomy of inter- and intraserotype variation in the human bacterial pathogen group A Streptococcus."
      Beres S.B., Richter E.W., Nagiec M.J., Sumby P., Porcella S.F., DeLeo F.R., Musser J.M.
      Proc. Natl. Acad. Sci. U.S.A. 103:7059-7064(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MGAS10750.

    Entry informationi

    Entry nameiPNP_STRPF
    AccessioniPrimary (citable) accession number: Q1J4N2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 29, 2008
    Last sequence update: June 13, 2006
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3