Q1J4C0 (FTHS2_STRPF) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Formate--tetrahydrofolate ligase 2
EC=6.3.4.3

Alternative name(s):
Formyltetrahydrofolate synthetase 2
Short name=FHS 2
Short name=FTHFS 2

Gene names

Name:	fhs2
Ordered Locus Names:	MGAS10750_Spy1866

Organism

Streptococcus pyogenes serotype M4 (strain MGAS10750) [Complete proteome] [HAMAP]

Taxonomic identifier

370554 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus

Protein attributes

Sequence length	557 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP MF_01543
Pathway	One-carbon metabolism; tetrahydrofolate interconversion. HAMAP MF_01543
Sequence similarities	Belongs to the formate--tetrahydrofolate ligase family.

Ontologies

Keywords
Biological process	One-carbon metabolism
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	folic acid-containing compound biosynthetic process Inferred from electronic annotation. Source: InterPro one-carbon metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW formate-tetrahydrofolate ligase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 557	557	Formate--tetrahydrofolate ligase 2 HAMAP MF_01543		PRO_0000293066
Regions
	Nucleotide binding	66 – 73	8	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q1J4C0 [UniParc]. Last modified June 13, 2006. Version 1. Checksum: DC64485B7C6E612B	FASTA	557	59,100
	10 20 30 40 50 60 MVLSDIEIAN SVSMEPISKV ADQLGIDKEA LCLYGKYKAK INARQLVALK DKPDGKLILV 70 80 90 100 110 120 TAISPTPAGE GKTTTSVGLV DALSAIGKKA VIALREPSLG PVFGVKGGAA GGGHAQVVPM 130 140 150 160 170 180 EDINLHFTGD FHAIGVANNL LAALIDNHIH HGNSLGIDSR RITWKRVVDM NDRQLRHIVD 190 200 210 220 230 240 GLQGKVNGVP REDGYDITVA SEIMAILCLS ENISDLKARL EKIIIGYNYQ GEPVTAKDLK 250 260 270 280 290 300 AGGALADLLK DAIHPNLVQT LEHTPALIHG GPFANIAHGC NSVLATKLAL KYGDYAVTEA 310 320 330 340 350 360 GFGADLGAEK FIDIKCRMSG LRPAAVVLVA TIRALKMHGG VQKTDLATEN VQAVVDGLPN 370 380 390 400 410 420 LDKHLANIQD VYGLPVVVAI NKFPLDTDAE LQAVYDACNK RGVDVVISDV WANGGAGGRE 430 440 450 460 470 480 LAEKVVTLAE QDNQFRFVYE EDDSIETKLT KIVTKVYGGK GITLSPAAKR ELADLERLGF 490 500 510 520 530 540 GNYPICMAKT QYSFSDDAKT LGAPTDFTVT ISNLKVSAGA GFIVALTGAI MTMPGLPKVP 550 ASETIDIDEE GNITGLF

References

[1]

"Molecular genetic anatomy of inter- and intraserotype variation in the human bacterial pathogen group A Streptococcus." Beres S.B., Richter E.W., Nagiec M.J., Sumby P., Porcella S.F., DeLeo F.R., Musser J.M. Proc. Natl. Acad. Sci. U.S.A. 103:7059-7064(2006) [PubMed: 16636287] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MGAS10750.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000262 Genomic DNA. Translation: ABF38816.1.
RefSeq	YP_603360.1. NC_008024.1.
3D structure databases
ProteinModelPortal	Q1J4C0.
SMR	Q1J4C0. Positions 5-555.
ModBase	Search...
Protein-protein interaction databases
STRING	Q1J4C0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTRT00000041168; EBSTRP00000039563; EBSTRG00000041165.
GeneID	4067181.
GenomeReviews	Gene locus fhs2 in contig CP000262_GR.
KEGG	spi:MGAS10750_Spy1866.
PATRIC	19730086. VBIStrPyo25933_1915.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG2759.
GeneTree	EBGT00050000027107.
HOGENOM	HBG677721.
OMA	TDFTVTI.
ProtClustDB	PRK13505.
Enzyme and pathway databases
BioCyc	SPYO370554:MGAS10750_SPY1866-MONOMER.
Family and domain databases
HAMAP	MF_01543. FTHFS. [Tree]
InterPro	IPR000559. Formate_THF_ligase. IPR020628. Formate_THF_ligase_CS. [Graphical view]
KO	K01938.
Pfam	PF01268. FTHFS. 1 hit. [Graphical view]
PROSITE	PS00721. FTHFS_1. 1 hit. PS00722. FTHFS_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FTHS2_STRPF

Accession

Primary (citable) accession number: Q1J4C0

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 10, 2007
Last sequence update:	June 13, 2006
Last modified:	January 25, 2012
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program