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Protein

Formimidoylglutamase

Gene

hutG

Organism
Streptococcus pyogenes serotype M4 (strain MGAS10750)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of N-formimidoyl-L-glutamate to L-glutamate and formamide.UniRule annotation

Catalytic activityi

N-formimidoyl-L-glutamate + H2O = L-glutamate + formamide.UniRule annotation

Cofactori

Mn2+UniRule annotationNote: Binds 2 manganese ions per subunit.UniRule annotation

Pathwayi: L-histidine degradation into L-glutamate

This protein is involved in step 1 of the subpathway that synthesizes L-glutamate from N-formimidoyl-L-glutamate (hydrolase route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Formimidoylglutamase (hutG)
This subpathway is part of the pathway L-histidine degradation into L-glutamate, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-glutamate from N-formimidoyl-L-glutamate (hydrolase route), the pathway L-histidine degradation into L-glutamate and in Amino-acid degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi133Manganese 1UniRule annotation1
Metal bindingi159Manganese 1UniRule annotation1
Metal bindingi159Manganese 2UniRule annotation1
Metal bindingi161Manganese 2UniRule annotation1
Metal bindingi163Manganese 1UniRule annotation1
Metal bindingi253Manganese 1UniRule annotation1
Metal bindingi253Manganese 2UniRule annotation1
Metal bindingi255Manganese 2UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processHistidine metabolism
LigandManganese, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00379; UER00552

Names & Taxonomyi

Protein namesi
Recommended name:
FormimidoylglutamaseUniRule annotation (EC:3.5.3.8UniRule annotation)
Alternative name(s):
FormiminoglutamaseUniRule annotation
Formiminoglutamate hydrolaseUniRule annotation
Gene namesi
Name:hutGUniRule annotation
Ordered Locus Names:MGAS10750_Spy1870
OrganismiStreptococcus pyogenes serotype M4 (strain MGAS10750)
Taxonomic identifieri370554 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000002434 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002582681 – 328FormimidoylglutamaseAdd BLAST328

Structurei

3D structure databases

ProteinModelPortaliQ1J4B6
SMRiQ1J4B6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the arginase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000237658
KOiK01479
OrthoDBiPOG091H04CY

Family and domain databases

HAMAPiMF_00737 Formimidoylglutam, 1 hit
InterProiView protein in InterPro
IPR005923 HutG
IPR006035 Ureohydrolase
IPR023696 Ureohydrolase_dom_sf
PfamiView protein in Pfam
PF00491 Arginase, 1 hit
PIRSFiPIRSF036979 Arginase, 1 hit
PRINTSiPR00116 ARGINASE
SUPFAMiSSF52768 SSF52768, 1 hit
PROSITEiView protein in PROSITE
PS51409 ARGINASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q1J4B6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLEDYYPSTT SYYHSGIDDD LYTAKWGMVM TFLDLNDSSL TPFEGTHFAL
60 70 80 90 100
IGFKSDKGVY INNGRVGAVE SPAAIRTQLA KFPWHLGNQV MVYDVGNIDG
110 120 130 140 150
PNRSLEQLQN SLSKAIKRMC DLNLKPIVLG GGHETAYGHY LGLRQSLSSS
160 170 180 190 200
DDLAVINMDA HFDLRPYDQT GPNSGTGFRQ MFDDAVADKR LFKYFVLGIQ
210 220 230 240 250
EHNNNLFLFD FVAKSKGIQF LTGQDIYQMG HQKVCRAIDR FLEGQERVYL
260 270 280 290 300
TIDMDCFSVG AAPGVSAIQS LGVDPNLAVL VLQHIAASGK LVGFDVVEVS
310 320
PPHDIDNHTA NLAATFIFYL VQIMAQHN
Length:328
Mass (Da):36,373
Last modified:October 31, 2006 - v2
Checksum:i23C6FBFA18FC748B
GO

Sequence cautioni

The sequence ABF38820 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000262 Genomic DNA Translation: ABF38820.1 Different initiation.
RefSeqiWP_002982269.1, NC_008024.1

Genome annotation databases

EnsemblBacteriaiABF38820; ABF38820; MGAS10750_Spy1870
KEGGispi:MGAS10750_Spy1870

Similar proteinsi

Entry informationi

Entry nameiHUTG_STRPF
AccessioniPrimary (citable) accession number: Q1J4B6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 31, 2006
Last modified: March 28, 2018
This is version 69 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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