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Protein

Allantoinase

Gene

allB

Organism
Deinococcus geothermalis (strain DSM 11300)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the conversion of allantoin (5-ureidohydantoin) to allantoic acid by hydrolytic cleavage of the five-member hydantoin ring.UniRule annotation

Catalytic activityi

(S)-allantoin + H2O = allantoate.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 2 Zn2+ ions per subunit.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi59 – 591Zinc 1UniRule annotation
Metal bindingi61 – 611Zinc 1UniRule annotation
Metal bindingi146 – 1461Zinc 1; via carbamate groupUniRule annotation
Metal bindingi146 – 1461Zinc 2; via carbamate groupUniRule annotation
Metal bindingi182 – 1821Zinc 2UniRule annotation
Metal bindingi238 – 2381Zinc 2UniRule annotation
Metal bindingi311 – 3111Zinc 1UniRule annotation

GO - Molecular functioni

  1. allantoinase activity Source: UniProtKB-HAMAP
  2. cobalt ion binding Source: InterPro
  3. dihydroorotase activity Source: InterPro
  4. zinc ion binding Source: InterPro

GO - Biological processi

  1. allantoin catabolic process Source: UniProtKB-HAMAP
  2. purine nucleobase metabolic process Source: UniProtKB-KW
  3. pyrimidine nucleotide biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Purine metabolism

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciDGEO319795:GHMU-2803-MONOMER.
UniPathwayiUPA00395; UER00653.

Names & Taxonomyi

Protein namesi
Recommended name:
AllantoinaseUniRule annotation (EC:3.5.2.5UniRule annotation)
Alternative name(s):
Allantoin-utilizing enzymeUniRule annotation
Gene namesi
Name:allBUniRule annotation
Ordered Locus Names:Dgeo_2609
Encoded oniPlasmid pDGEO010 Publication
OrganismiDeinococcus geothermalis (strain DSM 11300)
Taxonomic identifieri319795 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciDeinococcalesDeinococcaceaeDeinococcus
ProteomesiUP000002431 Componenti: Plasmid pDGEO01

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 449449AllantoinasePRO_0000317672Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei146 – 1461N6-carboxylysineUniRule annotation

Post-translational modificationi

Carbamylation allows a single lysine to coordinate two zinc ions.UniRule annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi319795.Dgeo_2609.

Structurei

3D structure databases

ProteinModelPortaliQ1J391.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DHOase family. Allantoinase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0044.
HOGENOMiHOG000219146.
KOiK01466.
OMAiHAEMIPP.
OrthoDBiEOG6KHFW6.

Family and domain databases

Gene3Di2.30.40.10. 1 hit.
HAMAPiMF_01645. Hydantoinase.
InterProiIPR017593. Allantoinase.
IPR004722. DHOase.
IPR002195. Dihydroorotase_CS.
IPR011059. Metal-dep_hydrolase_composite.
[Graphical view]
SUPFAMiSSF51338. SSF51338. 2 hits.
TIGRFAMsiTIGR03178. allantoinase. 1 hit.
TIGR00857. pyrC_multi. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1J391-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYDLLVRGGQ LVREGGVEQA DLGVVEERIV EIAPELMGDA REELDARGLH
60 70 80 90 100
VFPGAVDIHV HFNEPGRTDW EGIRTGSRAL VAGGGTVFAD MPLNSTPPVL
110 120 130 140 150
DRTTFEAKQQ AAERESYADF ALWGGLTPRN LDRLPELAEA GAVGFKAFMS
160 170 180 190 200
HSGLEEFESP DDFTLYEGML QARDLGLIVA LHAESDAITR GLSTRIRREG
210 220 230 240 250
GTGVRDYLRS RPAIAEVEAV NRALLLAEET GAKLHLVHLS TGRAVTLAAE
260 270 280 290 300
ARARGVDVSI ETCPHYLCFT GEDMERLGAV LKCAPPLRDA SEVDALWQAI
310 320 330 340 350
RAGHIDTIGS DHSPSTLDLK ERADFFEVWG GIAGVQSTLT VLLTEGRERG
360 370 380 390 400
LSLPDIARLS ARTPAGHFGL AGKGRLEPGA DADLVLVDLD REWVHTPEDL
410 420 430 440
HTRWKFSPYL GRTFRGRVVQ TRLRGQTVYA EGRFPHPPQG RFLRPAPAS
Length:449
Mass (Da):48,998
Last modified:June 13, 2006 - v1
Checksum:iF350C1502A58DDA3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000358 Genomic DNA. Translation: ABF44043.1.
RefSeqiWP_011525957.1. NC_008010.2.
YP_594117.1. NC_008010.2.

Genome annotation databases

EnsemblBacteriaiABF44043; ABF44043; Dgeo_2609.
KEGGidge:Dgeo_2609.
PATRICi21621500. VBIDeiGeo41128_0409.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000358 Genomic DNA. Translation: ABF44043.1.
RefSeqiWP_011525957.1. NC_008010.2.
YP_594117.1. NC_008010.2.

3D structure databases

ProteinModelPortaliQ1J391.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi319795.Dgeo_2609.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABF44043; ABF44043; Dgeo_2609.
KEGGidge:Dgeo_2609.
PATRICi21621500. VBIDeiGeo41128_0409.

Phylogenomic databases

eggNOGiCOG0044.
HOGENOMiHOG000219146.
KOiK01466.
OMAiHAEMIPP.
OrthoDBiEOG6KHFW6.

Enzyme and pathway databases

UniPathwayiUPA00395; UER00653.
BioCyciDGEO319795:GHMU-2803-MONOMER.

Family and domain databases

Gene3Di2.30.40.10. 1 hit.
HAMAPiMF_01645. Hydantoinase.
InterProiIPR017593. Allantoinase.
IPR004722. DHOase.
IPR002195. Dihydroorotase_CS.
IPR011059. Metal-dep_hydrolase_composite.
[Graphical view]
SUPFAMiSSF51338. SSF51338. 2 hits.
TIGRFAMsiTIGR03178. allantoinase. 1 hit.
TIGR00857. pyrC_multi. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 11300.

Entry informationi

Entry nameiALLB_DEIGD
AccessioniPrimary (citable) accession number: Q1J391
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: June 13, 2006
Last modified: April 1, 2015
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Plasmid, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.