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Protein

Allantoinase

Gene

allB

Organism
Deinococcus geothermalis (strain DSM 11300)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the conversion of allantoin (5-ureidohydantoin) to allantoic acid by hydrolytic cleavage of the five-member hydantoin ring.UniRule annotation

Catalytic activityi

(S)-allantoin + H2O = allantoate.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 2 Zn2+ ions per subunit.UniRule annotation

Pathwayi: (S)-allantoin degradation

This protein is involved in step 1 of the subpathway that synthesizes allantoate from (S)-allantoin.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Allantoinase (allB)
This subpathway is part of the pathway (S)-allantoin degradation, which is itself part of Nitrogen metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes allantoate from (S)-allantoin, the pathway (S)-allantoin degradation and in Nitrogen metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi59Zinc 1UniRule annotation1
Metal bindingi61Zinc 1UniRule annotation1
Metal bindingi146Zinc 1; via carbamate groupUniRule annotation1
Metal bindingi146Zinc 2; via carbamate groupUniRule annotation1
Metal bindingi182Zinc 2UniRule annotation1
Metal bindingi238Zinc 2UniRule annotation1
Metal bindingi311Zinc 1UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Purine metabolism

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00395; UER00653.

Names & Taxonomyi

Protein namesi
Recommended name:
AllantoinaseUniRule annotation (EC:3.5.2.5UniRule annotation)
Alternative name(s):
Allantoin-utilizing enzymeUniRule annotation
Gene namesi
Name:allBUniRule annotation
Ordered Locus Names:Dgeo_2609
Encoded oniPlasmid pDGEO010 Publication
OrganismiDeinococcus geothermalis (strain DSM 11300)
Taxonomic identifieri319795 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciDeinococcalesDeinococcaceaeDeinococcus
Proteomesi
  • UP000002431 Componenti: Plasmid pDGEO01

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003176721 – 449AllantoinaseAdd BLAST449

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei146N6-carboxylysineUniRule annotation1

Post-translational modificationi

Carbamylation allows a single lysine to coordinate two zinc ions.UniRule annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ1J391.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DHOase family. Allantoinase subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000219146.
KOiK01466.
OMAiEMIPPIT.
OrthoDBiPOG091H02CH.

Family and domain databases

Gene3Di2.30.40.10. 1 hit.
HAMAPiMF_01645. Hydantoinase. 1 hit.
InterProiIPR017593. Allantoinase.
IPR006680. Amidohydro-rel.
IPR004722. DHOase.
IPR002195. Dihydroorotase_CS.
IPR011059. Metal-dep_hydrolase_composite.
IPR032466. Metal_Hydrolase.
[Graphical view]
PfamiPF01979. Amidohydro_1. 1 hit.
[Graphical view]
SUPFAMiSSF51338. SSF51338. 2 hits.
SSF51556. SSF51556. 1 hit.
TIGRFAMsiTIGR03178. allantoinase. 1 hit.
TIGR00857. pyrC_multi. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1J391-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYDLLVRGGQ LVREGGVEQA DLGVVEERIV EIAPELMGDA REELDARGLH
60 70 80 90 100
VFPGAVDIHV HFNEPGRTDW EGIRTGSRAL VAGGGTVFAD MPLNSTPPVL
110 120 130 140 150
DRTTFEAKQQ AAERESYADF ALWGGLTPRN LDRLPELAEA GAVGFKAFMS
160 170 180 190 200
HSGLEEFESP DDFTLYEGML QARDLGLIVA LHAESDAITR GLSTRIRREG
210 220 230 240 250
GTGVRDYLRS RPAIAEVEAV NRALLLAEET GAKLHLVHLS TGRAVTLAAE
260 270 280 290 300
ARARGVDVSI ETCPHYLCFT GEDMERLGAV LKCAPPLRDA SEVDALWQAI
310 320 330 340 350
RAGHIDTIGS DHSPSTLDLK ERADFFEVWG GIAGVQSTLT VLLTEGRERG
360 370 380 390 400
LSLPDIARLS ARTPAGHFGL AGKGRLEPGA DADLVLVDLD REWVHTPEDL
410 420 430 440
HTRWKFSPYL GRTFRGRVVQ TRLRGQTVYA EGRFPHPPQG RFLRPAPAS
Length:449
Mass (Da):48,998
Last modified:June 13, 2006 - v1
Checksum:iF350C1502A58DDA3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000358 Genomic DNA. Translation: ABF44043.1.
RefSeqiWP_011525957.1. NC_008010.2.

Genome annotation databases

EnsemblBacteriaiABF44043; ABF44043; Dgeo_2609.
KEGGidge:Dgeo_2609.
PATRICi21621500. VBIDeiGeo41128_0409.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000358 Genomic DNA. Translation: ABF44043.1.
RefSeqiWP_011525957.1. NC_008010.2.

3D structure databases

ProteinModelPortaliQ1J391.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABF44043; ABF44043; Dgeo_2609.
KEGGidge:Dgeo_2609.
PATRICi21621500. VBIDeiGeo41128_0409.

Phylogenomic databases

HOGENOMiHOG000219146.
KOiK01466.
OMAiEMIPPIT.
OrthoDBiPOG091H02CH.

Enzyme and pathway databases

UniPathwayiUPA00395; UER00653.

Family and domain databases

Gene3Di2.30.40.10. 1 hit.
HAMAPiMF_01645. Hydantoinase. 1 hit.
InterProiIPR017593. Allantoinase.
IPR006680. Amidohydro-rel.
IPR004722. DHOase.
IPR002195. Dihydroorotase_CS.
IPR011059. Metal-dep_hydrolase_composite.
IPR032466. Metal_Hydrolase.
[Graphical view]
PfamiPF01979. Amidohydro_1. 1 hit.
[Graphical view]
SUPFAMiSSF51338. SSF51338. 2 hits.
SSF51556. SSF51556. 1 hit.
TIGRFAMsiTIGR03178. allantoinase. 1 hit.
TIGR00857. pyrC_multi. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiALLB_DEIGD
AccessioniPrimary (citable) accession number: Q1J391
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: June 13, 2006
Last modified: November 2, 2016
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Plasmid, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.