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Q1J391

- ALLB_DEIGD

UniProt

Q1J391 - ALLB_DEIGD

Protein

Allantoinase

Gene

allB

Organism
Deinococcus geothermalis (strain DSM 11300)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 1 (13 Jun 2006)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the conversion of allantoin (5-ureidohydantoin) to allantoic acid by hydrolytic cleavage of the five-member hydantoin ring.UniRule annotation

    Catalytic activityi

    (S)-allantoin + H2O = allantoate.UniRule annotation

    Cofactori

    Binds 2 zinc ions per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi59 – 591Zinc 1UniRule annotation
    Metal bindingi61 – 611Zinc 1UniRule annotation
    Metal bindingi146 – 1461Zinc 1; via carbamate groupUniRule annotation
    Metal bindingi146 – 1461Zinc 2; via carbamate groupUniRule annotation
    Metal bindingi182 – 1821Zinc 2UniRule annotation
    Metal bindingi238 – 2381Zinc 2UniRule annotation
    Metal bindingi311 – 3111Zinc 1UniRule annotation

    GO - Molecular functioni

    1. allantoinase activity Source: UniProtKB-HAMAP
    2. cobalt ion binding Source: InterPro
    3. dihydroorotase activity Source: InterPro
    4. zinc ion binding Source: InterPro

    GO - Biological processi

    1. allantoin catabolic process Source: UniProtKB-HAMAP
    2. purine nucleobase metabolic process Source: UniProtKB-KW
    3. pyrimidine nucleotide biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Purine metabolism

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    BioCyciDGEO319795:GHMU-2803-MONOMER.
    UniPathwayiUPA00395; UER00653.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    AllantoinaseUniRule annotation (EC:3.5.2.5UniRule annotation)
    Alternative name(s):
    Allantoin-utilizing enzymeUniRule annotation
    Gene namesi
    Name:allBUniRule annotation
    Ordered Locus Names:Dgeo_2609
    Encoded oniPlasmid pDGEO010 Publication
    OrganismiDeinococcus geothermalis (strain DSM 11300)
    Taxonomic identifieri319795 [NCBI]
    Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciDeinococcalesDeinococcaceaeDeinococcus
    ProteomesiUP000002431: Plasmid pDGEO01

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 449449AllantoinasePRO_0000317672Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei146 – 1461N6-carboxylysineUniRule annotation

    Post-translational modificationi

    Carbamylation allows a single lysine to coordinate two zinc ions.UniRule annotation

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Protein-protein interaction databases

    STRINGi319795.Dgeo_2609.

    Structurei

    3D structure databases

    ProteinModelPortaliQ1J391.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the DHOase family. Allantoinase subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0044.
    HOGENOMiHOG000219146.
    KOiK01466.
    OMAiCSPWEGH.
    OrthoDBiEOG6KHFW6.

    Family and domain databases

    Gene3Di2.30.40.10. 1 hit.
    HAMAPiMF_01645. Hydantoinase.
    InterProiIPR017593. Allantoinase.
    IPR004722. DHOase.
    IPR002195. Dihydroorotase_CS.
    IPR011059. Metal-dep_hydrolase_composite.
    [Graphical view]
    SUPFAMiSSF51338. SSF51338. 2 hits.
    TIGRFAMsiTIGR03178. allantoinase. 1 hit.
    TIGR00857. pyrC_multi. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q1J391-1 [UniParc]FASTAAdd to Basket

    « Hide

    MYDLLVRGGQ LVREGGVEQA DLGVVEERIV EIAPELMGDA REELDARGLH    50
    VFPGAVDIHV HFNEPGRTDW EGIRTGSRAL VAGGGTVFAD MPLNSTPPVL 100
    DRTTFEAKQQ AAERESYADF ALWGGLTPRN LDRLPELAEA GAVGFKAFMS 150
    HSGLEEFESP DDFTLYEGML QARDLGLIVA LHAESDAITR GLSTRIRREG 200
    GTGVRDYLRS RPAIAEVEAV NRALLLAEET GAKLHLVHLS TGRAVTLAAE 250
    ARARGVDVSI ETCPHYLCFT GEDMERLGAV LKCAPPLRDA SEVDALWQAI 300
    RAGHIDTIGS DHSPSTLDLK ERADFFEVWG GIAGVQSTLT VLLTEGRERG 350
    LSLPDIARLS ARTPAGHFGL AGKGRLEPGA DADLVLVDLD REWVHTPEDL 400
    HTRWKFSPYL GRTFRGRVVQ TRLRGQTVYA EGRFPHPPQG RFLRPAPAS 449
    Length:449
    Mass (Da):48,998
    Last modified:June 13, 2006 - v1
    Checksum:iF350C1502A58DDA3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000358 Genomic DNA. Translation: ABF44043.1.
    RefSeqiWP_011525957.1. NC_008010.2.
    YP_594117.1. NC_008010.2.

    Genome annotation databases

    EnsemblBacteriaiABF44043; ABF44043; Dgeo_2609.
    GeneIDi4073840.
    KEGGidge:Dgeo_2609.
    PATRICi21621500. VBIDeiGeo41128_0409.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000358 Genomic DNA. Translation: ABF44043.1 .
    RefSeqi WP_011525957.1. NC_008010.2.
    YP_594117.1. NC_008010.2.

    3D structure databases

    ProteinModelPortali Q1J391.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 319795.Dgeo_2609.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABF44043 ; ABF44043 ; Dgeo_2609 .
    GeneIDi 4073840.
    KEGGi dge:Dgeo_2609.
    PATRICi 21621500. VBIDeiGeo41128_0409.

    Phylogenomic databases

    eggNOGi COG0044.
    HOGENOMi HOG000219146.
    KOi K01466.
    OMAi CSPWEGH.
    OrthoDBi EOG6KHFW6.

    Enzyme and pathway databases

    UniPathwayi UPA00395 ; UER00653 .
    BioCyci DGEO319795:GHMU-2803-MONOMER.

    Family and domain databases

    Gene3Di 2.30.40.10. 1 hit.
    HAMAPi MF_01645. Hydantoinase.
    InterProi IPR017593. Allantoinase.
    IPR004722. DHOase.
    IPR002195. Dihydroorotase_CS.
    IPR011059. Metal-dep_hydrolase_composite.
    [Graphical view ]
    SUPFAMi SSF51338. SSF51338. 2 hits.
    TIGRFAMsi TIGR03178. allantoinase. 1 hit.
    TIGR00857. pyrC_multi. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 11300.

    Entry informationi

    Entry nameiALLB_DEIGD
    AccessioniPrimary (citable) accession number: Q1J391
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: June 13, 2006
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Plasmid, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3