Reviewed, UniProtKB/Swiss-Prot Q1J391 (ALLB_DEIGD)

Names and origin

Protein names

Recommended name:
    Allantoinase
    EC=3.5.2.5
Alternative name(s):
    Allantoin-utilizing enzyme

Gene names

Name:	allB
Ordered Locus Names:	Dgeo_2609

Encoded on

Plasmid pDSM11300

Organism

Deinococcus geothermalis (strain DSM 11300) [Complete proteome] [HAMAP]

Taxonomic identifier

319795 [NCBI]

Taxonomic lineage

Bacteria › Deinococcus-Thermus › Deinococci › Deinococcales › Deinococcaceae › Deinococcus

Protein attributes

Sequence length	449 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the conversion of allantoin (5-ureidohydantoin) to allantoic acid by hydrolytic cleavage of the five-member hydantoin ring By similarity.
Catalytic activity	(S)-allantoin + H2O = allantoate. HAMAP MF_01645
Cofactor	Binds 2 zinc ions per subunit By similarity.
Pathway	Nitrogen metabolism; (S)-allantoin degradation; allantoate from (S)-allantoin: step 1/1. HAMAP MF_01645
Subunit structure	Homotetramer By similarity.
Post-translational modification	Carbamylation allows a single lysine to coordinate two zinc ions By similarity.
Sequence similarities	Belongs to the DHOase family. Allantoinase subfamily.

Ontologies

Keywords
Biological process	Purine metabolism
Ligand	Metal-binding Zinc
Molecular function	Hydrolase
Technical term	Complete proteome Plasmid
Gene Ontology (GO)
Biological process	allantoin catabolic process Inferred from electronic annotation. Source: HAMAP purine base metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	allantoinase activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 449	449	Allantoinase HAMAP MF_01645		PRO_0000317672
Sites
	Metal binding	59	1	Zinc 1 By similarity
	Metal binding	61	1	Zinc 1 By similarity
	Metal binding	146	1	Zinc 1; via carbamate group By similarity
	Metal binding	146	1	Zinc 2; via carbamate group By similarity
	Metal binding	182	1	Zinc 2 By similarity
	Metal binding	238	1	Zinc 2 By similarity
	Metal binding	311	1	Zinc 1 By similarity
Amino acid modifications
	Modified residue	146	1	N6-carboxylysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q1J391-1 [UniParc]. Last modified June 13, 2006. Version 1. Checksum: F350C1502A58DDA3	FASTA	449	48,998
	10 20 30 40 50 60 MYDLLVRGGQ LVREGGVEQA DLGVVEERIV EIAPELMGDA REELDARGLH VFPGAVDIHV 70 80 90 100 110 120 HFNEPGRTDW EGIRTGSRAL VAGGGTVFAD MPLNSTPPVL DRTTFEAKQQ AAERESYADF 130 140 150 160 170 180 ALWGGLTPRN LDRLPELAEA GAVGFKAFMS HSGLEEFESP DDFTLYEGML QARDLGLIVA 190 200 210 220 230 240 LHAESDAITR GLSTRIRREG GTGVRDYLRS RPAIAEVEAV NRALLLAEET GAKLHLVHLS 250 260 270 280 290 300 TGRAVTLAAE ARARGVDVSI ETCPHYLCFT GEDMERLGAV LKCAPPLRDA SEVDALWQAI 310 320 330 340 350 360 RAGHIDTIGS DHSPSTLDLK ERADFFEVWG GIAGVQSTLT VLLTEGRERG LSLPDIARLS 370 380 390 400 410 420 ARTPAGHFGL AGKGRLEPGA DADLVLVDLD REWVHTPEDL HTRWKFSPYL GRTFRGRVVQ 430 440 TRLRGQTVYA EGRFPHPPQG RFLRPAPAS

References

[1]

"Complete sequence of plasmid 1 of Deinococcus geothermalis DSM 11300." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Brettin T., Bruce D., Han C., Tapia R., Saunders E., Gilna P., Schmutz J. , Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Daly M.J., Fredrickson J.K., Makarova K.S., Gaidamakova E.K., Zhai M., Richardson P. Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000358 Genomic DNA. Translation: ABF44043.1.
RefSeq	YP_594117.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q1J391.
Genome annotation databases
GeneID	4073840.
GenomeReviews	Gene locus Dgeo_2609 in contig CP000358_GR.
KEGG	dge:Dgeo_2609.
NMPDR	fig|68909.1.peg.21.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q1J391.
OMA	LKCAPPL.
Enzyme and pathway databases
BioCyc	DGEO319795:DGEO_2609-MON.
Family and domain databases
HAMAP	MF_01645. [Tree]
InterPro	IPR017593. Allantoinase. IPR006680. Amidohydro_1. IPR004722. DHOmult. [Graphical view]
Pfam	PF01979. Amidohydro_1. 1 hit. [Graphical view]
TIGRFAMs	TIGR03178. allantoinase. 1 hit. TIGR00857. pyrC_multi. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ALLB_DEIGD

Accession

Primary (citable) accession number: Q1J391

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	June 13, 2006
Last modified:	November 3, 2009
This is version 27 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)