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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Deinococcus geothermalis (strain DSM 11300)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei589 – 5891ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciDGEO319795:GHMU-584-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Dgeo_0567
OrganismiDeinococcus geothermalis (strain DSM 11300)
Taxonomic identifieri319795 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciDeinococcalesDeinococcaceaeDeinococcus
ProteomesiUP000002431: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 819819Leucine--tRNA ligasePRO_0000334748Add
BLAST

Proteomic databases

PRIDEiQ1J0W5.

Interactioni

Protein-protein interaction databases

STRINGi319795.Dgeo_0567.

Structurei

3D structure databases

ProteinModelPortaliQ1J0W5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi51 – 6111"HIGH" regionAdd
BLAST
Motifi586 – 5905"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiQSSWYFL.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1J0W5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKPEIREPR AERYNPHAIE PKWQARWEQE GLYTFHEDPS KTKHYALTMF
60 70 80 90 100
PYPSGNLHIG HWYANVAPDA HARWMRMRGY NVFFPMGFDA FGLPAENAAI
110 120 130 140 150
KHGLNPATWT SSNIEHMLGQ FKRMGTMIDW SRSLATCDPE YYRWNQWFFT
160 170 180 190 200
EFFRRGLAYK KDGLVNWCPK DQTVLANEQV VDGRCERCGT PVERRNLSQW
210 220 230 240 250
YLKITDYAEE LLDFRDTDMP ERVRAMQTNW IGKSVGAEIT FDTPAGPETV
260 270 280 290 300
FTTRPDTLMG ATFLVLAPEH PKVPALTTPE QAEAVRAYVE AAGRKTDVER
310 320 330 340 350
QQELGEKTGV FTGSYATHPV TGHQIPIWVA DYVLMTYGTG SIMAVPAHDE
360 370 380 390 400
RDFDFARKFG LEIREVIRPE GGEPLDTTQA PYVGEGVIVN SGEFDGLPGG
410 420 430 440 450
KASIAPIIAR LEALGVAKPK TTYRLRDWLV SRQRYWGTPI PIVYCPDHGA
460 470 480 490 500
QPVPADQLPV KLPENVEFMP TGQSPLKLDR EWMRATCPVC GGPAERDTDT
510 520 530 540 550
MDTFVDSSWY MYRYLSPHDD QHPFDPAHAN LLPVDLYTGG IEHAILHLLY
560 570 580 590 600
SRFWTKVMRD MGLTVQNEPF ARLRNQGIIL GEDGEKMSKS RGNVVDPDDL
610 620 630 640 650
VREYGADTVR TYLMFIAPWE LGGPWDPSGI NGPAKWLSRV WALYFDEKAA
660 670 680 690 700
GPEEKIGEAD LRYAVHSTLK KVGADYERMS FNTIIAALME LTNTLVKAKR
710 720 730 740 750
SPVFGTPAWE EALDIFNRML APVAPHIAEE IWRERGGTES VHLQAWPAVD
760 770 780 790 800
EAAATRDTVT IGVQVSGKIR GEVQISKTAT AEEALAAARA HPDVAKFTEG
810
KQTIKEIYVP GRIINIVVK
Length:819
Mass (Da):92,337
Last modified:June 13, 2006 - v1
Checksum:i833A11110FC061E9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000359 Genomic DNA. Translation: ABF44869.1.
RefSeqiWP_011529711.1. NC_008025.1.
YP_604038.1. NC_008025.1.

Genome annotation databases

EnsemblBacteriaiABF44869; ABF44869; Dgeo_0567.
GeneIDi4058578.
KEGGidge:Dgeo_0567.
PATRICi21622981. VBIDeiGeo41128_1132.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000359 Genomic DNA. Translation: ABF44869.1.
RefSeqiWP_011529711.1. NC_008025.1.
YP_604038.1. NC_008025.1.

3D structure databases

ProteinModelPortaliQ1J0W5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi319795.Dgeo_0567.

Proteomic databases

PRIDEiQ1J0W5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABF44869; ABF44869; Dgeo_0567.
GeneIDi4058578.
KEGGidge:Dgeo_0567.
PATRICi21622981. VBIDeiGeo41128_1132.

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiQSSWYFL.
OrthoDBiEOG63Z74X.

Enzyme and pathway databases

BioCyciDGEO319795:GHMU-584-MONOMER.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 11300.

Entry informationi

Entry nameiSYL_DEIGD
AccessioniPrimary (citable) accession number: Q1J0W5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: June 13, 2006
Last modified: March 4, 2015
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.