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Q1J0W5

- SYL_DEIGD

UniProt

Q1J0W5 - SYL_DEIGD

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Protein

Leucine--tRNA ligase

Gene
leuS, Dgeo_0567
Organism
Deinococcus geothermalis (strain DSM 11300)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei589 – 5891ATP By similarity

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciDGEO319795:GHMU-584-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:Dgeo_0567
OrganismiDeinococcus geothermalis (strain DSM 11300)
Taxonomic identifieri319795 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciDeinococcalesDeinococcaceaeDeinococcus
ProteomesiUP000002431: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 819819Leucine--tRNA ligaseUniRule annotationPRO_0000334748Add
BLAST

Proteomic databases

PRIDEiQ1J0W5.

Interactioni

Protein-protein interaction databases

STRINGi319795.Dgeo_0567.

Structurei

3D structure databases

ProteinModelPortaliQ1J0W5.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi51 – 6111"HIGH" regionUniRule annotationAdd
BLAST
Motifi586 – 5905"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1J0W5-1 [UniParc]FASTAAdd to Basket

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MTKPEIREPR AERYNPHAIE PKWQARWEQE GLYTFHEDPS KTKHYALTMF    50
PYPSGNLHIG HWYANVAPDA HARWMRMRGY NVFFPMGFDA FGLPAENAAI 100
KHGLNPATWT SSNIEHMLGQ FKRMGTMIDW SRSLATCDPE YYRWNQWFFT 150
EFFRRGLAYK KDGLVNWCPK DQTVLANEQV VDGRCERCGT PVERRNLSQW 200
YLKITDYAEE LLDFRDTDMP ERVRAMQTNW IGKSVGAEIT FDTPAGPETV 250
FTTRPDTLMG ATFLVLAPEH PKVPALTTPE QAEAVRAYVE AAGRKTDVER 300
QQELGEKTGV FTGSYATHPV TGHQIPIWVA DYVLMTYGTG SIMAVPAHDE 350
RDFDFARKFG LEIREVIRPE GGEPLDTTQA PYVGEGVIVN SGEFDGLPGG 400
KASIAPIIAR LEALGVAKPK TTYRLRDWLV SRQRYWGTPI PIVYCPDHGA 450
QPVPADQLPV KLPENVEFMP TGQSPLKLDR EWMRATCPVC GGPAERDTDT 500
MDTFVDSSWY MYRYLSPHDD QHPFDPAHAN LLPVDLYTGG IEHAILHLLY 550
SRFWTKVMRD MGLTVQNEPF ARLRNQGIIL GEDGEKMSKS RGNVVDPDDL 600
VREYGADTVR TYLMFIAPWE LGGPWDPSGI NGPAKWLSRV WALYFDEKAA 650
GPEEKIGEAD LRYAVHSTLK KVGADYERMS FNTIIAALME LTNTLVKAKR 700
SPVFGTPAWE EALDIFNRML APVAPHIAEE IWRERGGTES VHLQAWPAVD 750
EAAATRDTVT IGVQVSGKIR GEVQISKTAT AEEALAAARA HPDVAKFTEG 800
KQTIKEIYVP GRIINIVVK 819
Length:819
Mass (Da):92,337
Last modified:June 13, 2006 - v1
Checksum:i833A11110FC061E9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000359 Genomic DNA. Translation: ABF44869.1.
RefSeqiYP_604038.1. NC_008025.1.

Genome annotation databases

EnsemblBacteriaiABF44869; ABF44869; Dgeo_0567.
GeneIDi4058578.
KEGGidge:Dgeo_0567.
PATRICi21622981. VBIDeiGeo41128_1132.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000359 Genomic DNA. Translation: ABF44869.1 .
RefSeqi YP_604038.1. NC_008025.1.

3D structure databases

ProteinModelPortali Q1J0W5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 319795.Dgeo_0567.

Proteomic databases

PRIDEi Q1J0W5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABF44869 ; ABF44869 ; Dgeo_0567 .
GeneIDi 4058578.
KEGGi dge:Dgeo_0567.
PATRICi 21622981. VBIDeiGeo41128_1132.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci DGEO319795:GHMU-584-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 11300.

Entry informationi

Entry nameiSYL_DEIGD
AccessioniPrimary (citable) accession number: Q1J0W5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: June 13, 2006
Last modified: May 14, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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