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Q1J0W5

- SYL_DEIGD

UniProt

Q1J0W5 - SYL_DEIGD

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Deinococcus geothermalis (strain DSM 11300)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 72 (01 Oct 2014)
      Sequence version 1 (13 Jun 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei589 – 5891ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciDGEO319795:GHMU-584-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:Dgeo_0567
    OrganismiDeinococcus geothermalis (strain DSM 11300)
    Taxonomic identifieri319795 [NCBI]
    Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciDeinococcalesDeinococcaceaeDeinococcus
    ProteomesiUP000002431: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 819819Leucine--tRNA ligasePRO_0000334748Add
    BLAST

    Proteomic databases

    PRIDEiQ1J0W5.

    Interactioni

    Protein-protein interaction databases

    STRINGi319795.Dgeo_0567.

    Structurei

    3D structure databases

    ProteinModelPortaliQ1J0W5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi51 – 6111"HIGH" regionAdd
    BLAST
    Motifi586 – 5905"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200748.
    KOiK01869.
    OMAiHISHELW.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q1J0W5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTKPEIREPR AERYNPHAIE PKWQARWEQE GLYTFHEDPS KTKHYALTMF    50
    PYPSGNLHIG HWYANVAPDA HARWMRMRGY NVFFPMGFDA FGLPAENAAI 100
    KHGLNPATWT SSNIEHMLGQ FKRMGTMIDW SRSLATCDPE YYRWNQWFFT 150
    EFFRRGLAYK KDGLVNWCPK DQTVLANEQV VDGRCERCGT PVERRNLSQW 200
    YLKITDYAEE LLDFRDTDMP ERVRAMQTNW IGKSVGAEIT FDTPAGPETV 250
    FTTRPDTLMG ATFLVLAPEH PKVPALTTPE QAEAVRAYVE AAGRKTDVER 300
    QQELGEKTGV FTGSYATHPV TGHQIPIWVA DYVLMTYGTG SIMAVPAHDE 350
    RDFDFARKFG LEIREVIRPE GGEPLDTTQA PYVGEGVIVN SGEFDGLPGG 400
    KASIAPIIAR LEALGVAKPK TTYRLRDWLV SRQRYWGTPI PIVYCPDHGA 450
    QPVPADQLPV KLPENVEFMP TGQSPLKLDR EWMRATCPVC GGPAERDTDT 500
    MDTFVDSSWY MYRYLSPHDD QHPFDPAHAN LLPVDLYTGG IEHAILHLLY 550
    SRFWTKVMRD MGLTVQNEPF ARLRNQGIIL GEDGEKMSKS RGNVVDPDDL 600
    VREYGADTVR TYLMFIAPWE LGGPWDPSGI NGPAKWLSRV WALYFDEKAA 650
    GPEEKIGEAD LRYAVHSTLK KVGADYERMS FNTIIAALME LTNTLVKAKR 700
    SPVFGTPAWE EALDIFNRML APVAPHIAEE IWRERGGTES VHLQAWPAVD 750
    EAAATRDTVT IGVQVSGKIR GEVQISKTAT AEEALAAARA HPDVAKFTEG 800
    KQTIKEIYVP GRIINIVVK 819
    Length:819
    Mass (Da):92,337
    Last modified:June 13, 2006 - v1
    Checksum:i833A11110FC061E9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000359 Genomic DNA. Translation: ABF44869.1.
    RefSeqiYP_604038.1. NC_008025.1.

    Genome annotation databases

    EnsemblBacteriaiABF44869; ABF44869; Dgeo_0567.
    GeneIDi4058578.
    KEGGidge:Dgeo_0567.
    PATRICi21622981. VBIDeiGeo41128_1132.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000359 Genomic DNA. Translation: ABF44869.1 .
    RefSeqi YP_604038.1. NC_008025.1.

    3D structure databases

    ProteinModelPortali Q1J0W5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 319795.Dgeo_0567.

    Proteomic databases

    PRIDEi Q1J0W5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABF44869 ; ABF44869 ; Dgeo_0567 .
    GeneIDi 4058578.
    KEGGi dge:Dgeo_0567.
    PATRICi 21622981. VBIDeiGeo41128_1132.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200748.
    KOi K01869.
    OMAi HISHELW.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci DGEO319795:GHMU-584-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 11300.

    Entry informationi

    Entry nameiSYL_DEIGD
    AccessioniPrimary (citable) accession number: Q1J0W5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: June 13, 2006
    Last modified: October 1, 2014
    This is version 72 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3