Q1J0V4 (Q1J0V4_DEIGD) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Thymidine kinase HAMAP MF_00124 RuleBase RU000544
EC=2.7.1.21 HAMAP MF_00124 RuleBase RU000544

Gene names

Name:	tdk HAMAP MF_00124
Ordered Locus Names:	Dgeo_0578

Organism

Deinococcus geothermalis (strain DSM 11300) [Complete proteome] [HAMAP]

Taxonomic identifier

319795 [NCBI]

Taxonomic lineage

Bacteria › Deinococcus-Thermus › Deinococci › Deinococcales › Deinococcaceae › Deinococcus

Protein attributes

Sequence length	219 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + thymidine = ADP + thymidine 5'-phosphate. HAMAP MF_00124 RuleBase RU000544 SAAS SAAS020634
Subunit structure	Homotetramer By similarity. HAMAP MF_00124 SAAS SAAS020634
Subcellular location	Cytoplasm By similarity HAMAP MF_00124 SAAS SAAS020634.
Sequence similarities	Belongs to the thymidine kinase family. HAMAP MF_00124 RuleBase RU004165

Ontologies

Keywords
Biological process	DNA synthesis HAMAP MF_00124 SAAS SAAS020634 RuleBase RU000544
Cellular component	Cytoplasm HAMAP MF_00124 SAAS SAAS020634
Ligand	ATP-binding HAMAP MF_00124 SAAS SAAS020634 RuleBase RU000544 Metal-binding HAMAP MF_00124 SAAS SAAS020634 Nucleotide-binding Zinc HAMAP MF_00124 SAAS SAAS020634
Molecular function	Kinase HAMAP MF_00124 SAAS SAAS020634 RuleBase RU000544 EMBL ABF44880.1 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	DNA replication Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP thymidine kinase activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Nucleotide binding	32 – 39	8	ATP By similarity HAMAP MF_00124
	Nucleotide binding	116 – 119	4	ATP By similarity HAMAP MF_00124
Sites
	Active site	117	1	Proton acceptor By similarity HAMAP MF_00124
	Metal binding	173	1	Zinc By similarity HAMAP MF_00124
	Metal binding	176	1	Zinc By similarity HAMAP MF_00124
	Metal binding	211	1	Zinc By similarity HAMAP MF_00124
	Metal binding	214	1	Zinc By similarity HAMAP MF_00124

Sequences

	Sequence		Length	Mass (Da)
	Q1J0V4 [UniParc]. Last modified June 13, 2006. Version 1. Checksum: CF70ECC202850FBC	FASTA	219	23,529
	10 20 30 40 50 60 MLCCACQFLR SAIIPLVLKS PYHGGHLEVI VGPMFSGKSE ELIRRVTRAV IARQRVAVFK 70 80 90 100 110 120 PAIDDRYHAT HVASHTGRRI EAVAVPDAAA IRAYLAGEGP LLSSPGTALP DVVGVDEAQF 130 140 150 160 170 180 FGSDLGPLVL ELAEAGVRVI LAGLDLDFRA EPFGCMPDLL ARAESVEKLT AICTVCGAPA 190 200 210 TRSQRLIAGQ PARFDDPVVL VGAEEAYEAR CRVHHEVRR

References

[1]

"Complete sequence of chromosome 1 of Deinococcus geothermalis DSM 11300." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Brettin T., Bruce D., Han C., Tapia R., Saunders E., Gilna P., Schmutz J. , Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Daly M.J., Fredrickson J.K., Makarova K.S., Gaidamakova E.K., Zhai M., Richardson P. Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000359 Genomic DNA. Translation: ABF44880.1.
RefSeq	YP_604049.1. NC_008025.1.
3D structure databases
ProteinModelPortal	Q1J0V4.
ModBase	Search...
Protein-protein interaction databases
STRING	Q1J0V4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4058589.
GenomeReviews	Gene locus Dgeo_0578 in contig CP000359_GR.
KEGG	dge:Dgeo_0578.
NMPDR	fig|68909.1.peg.880.
PATRIC	21623003. VBIDeiGeo41128_1143.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1435.
HOGENOM	HBG522108.
OMA	EPRCRHH.
PhylomeDB	Q1J0V4.
ProtClustDB	PRK04296.
Family and domain databases
HAMAP	MF_00124. Thymidine_kinase. [Tree]
InterPro	IPR001267. Thymidine_kinase. IPR020633. Thymidine_kinase_CS. IPR020634. Thymidine_kinase_subgr. [Graphical view]
KO	K00857.
PANTHER	PTHR11441. TK_cell. 1 hit.
Pfam	PF00265. TK. 1 hit. [Graphical view]
PIRSF	PIRSF035805. TK_cell. 1 hit.
PROSITE	PS00603. TK_CELLULAR_TYPE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q1J0V4_DEIGD

Accession

Primary (citable) accession number: Q1J0V4

Entry history

Integrated into UniProtKB/TrEMBL:	June 13, 2006
Last sequence update:	June 13, 2006
Last modified:	December 14, 2011
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)