Q1J0P6 (RPOB_DEIGD) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
DNA-directed RNA polymerase subunit beta
Short name=RNAP subunit beta
EC=2.7.7.6

Alternative name(s):
RNA polymerase subunit beta
Transcriptase subunit beta

Gene names

Name:	rpoB
Ordered Locus Names:	Dgeo_0636

Organism

Deinococcus geothermalis (strain DSM 11300) [Complete proteome] [HAMAP]

Taxonomic identifier

319795 [NCBI]

Taxonomic lineage

Bacteria › Deinococcus-Thermus › Deinococci › Deinococcales › Deinococcaceae › Deinococcus

Protein attributes

Sequence length	1152 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. HAMAP MF_01321
Catalytic activity	Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). HAMAP MF_01321
Subunit structure	The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription By similarity.
Sequence similarities	Belongs to the RNA polymerase beta chain family.

Ontologies

Keywords
Biological process	Transcription
Cellular component	DNA-directed RNA polymerase
Molecular function	Nucleotidyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	DNA binding Inferred from electronic annotation. Source: InterPro DNA-directed RNA polymerase activity Inferred from electronic annotation. Source: UniProtKB-KW ribonucleoside binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1152	1152	DNA-directed RNA polymerase subunit beta HAMAP MF_01321		PRO_0000300306

Sequences

	Sequence		Length	Mass (Da)
	Q1J0P6 [UniParc]. Last modified June 13, 2006. Version 1. Checksum: 96B3CDD047D81E7E	FASTA	1,152	127,384
	10 20 30 40 50 60 MSLTDQKPRI ERFGEITEVI PLPNLTEVQV NSFKAFLQAD KAPDERDDTG LQSAFREVFP 70 80 90 100 110 120 IDETEKGRST GLVLDFLEYR LGEPPYTPEE CREKDLTYQA PLYAKLQLIH KDSGLIKEDQ 130 140 150 160 170 180 VFLGDLPLMT DDGSFVINGA DRVVISQIHR SPGVYFTSSY KGIKKMYTAA IIPMPKRGPW 190 200 210 220 230 240 IELEFNGGVL EMKVNKRKFP VSLLLRVLGY DDAQLKALFT EFDPAAELPE DKSAGMNPDE 250 260 270 280 290 300 ALLRLFTVLR PGDPPKRDKA IQYLYGLLAD PKRYDLGEPG RFKMNTKLGT RRQDRTLLTF 310 320 330 340 350 360 EDGRFGDAGL VDTIRYLMAL QQGLETVTMG ADEDGVAIEV PVTEDDIDHL GNRRVRTVGE 370 380 390 400 410 420 LLADQLRVGM GRMARGVRER MLLGNPDAAT PTKLVNNRPI VAAMREFFGR SQLSQFKDQT 430 440 450 460 470 480 NPLSDLRHKR RISALGPGGL TRERAGFDVR DVHRTHYGRI CPIETPEGAN IGLISSLSSY 490 500 510 520 530 540 AKVNDLGFIE APYRRVVDGR VTDDVVYMTA DIEDRYVIAQ ANSPLNPDGT FAEERVLARK 550 560 570 580 590 600 KGDPMLYAPT EVDFMDVSPK QIVSINTSLI PFLEHDDANR ALMGSNMQSQ AVPLVRADSP 610 620 630 640 650 660 AVGTGVEERV VTDSGTSVIS DVTGRVTYVD ARAIQVTLTE DAPQIGLVKG NVRTFELVRF 670 680 690 700 710 720 TRSNQGTNLD QHPIVSVGDE VVPGQVIADG PASDQGRLAL GQNITIAIMP FDGFNFEDAI 730 740 750 760 770 780 CISEGLVRKD FYTSVHIEKD EIEARDTKLG PEKITRDIPG LSEAALRDLD EDGIVRVGAE 790 800 810 820 830 840 VKPGDILVGK TSFKGESEPT PEERLLRSIF GEKAREVKDT SLRVQSGQGG IVVKTVRFRR 850 860 870 880 890 900 GDEGVDLKPG VREMVRVYVA QKRQLQVGDK VANRHGNKGV VSKILPPEDM PYLEDGTPVD 910 920 930 940 950 960 LVFNPLGVPS RMNLGQILET HLGEVARLTG QKFVTPVFDS ATEEAIKEML EVAAAERLQR 970 980 990 1000 1010 1020 RKDEGFELDK REQEVLDRAG KLGVISPPNG DYAAAQMQLA RTGKSVLYDG RTGEPISGPV 1030 1040 1050 1060 1070 1080 VVGTMYVMKL YHMVEDKLHA RSTGPYSLIT QQPLGGKAQF GGQRFGEMEV WALEAYGAAH 1090 1100 1110 1120 1130 1140 TLQEMLTIKS DDIDGRDAAY QSIVKGEEVS GSTIPESFKV LVKELHSLGL DVEVLDNNDK 1150 PVDIFEGMMP KR

References

[1]

"Complete sequence of chromosome 1 of Deinococcus geothermalis DSM 11300." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Brettin T., Bruce D., Han C., Tapia R., Saunders E., Gilna P., Schmutz J. , Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Daly M.J., Fredrickson J.K., Makarova K.S., Gaidamakova E.K., Zhai M., Richardson P. Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 11300.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000359 Genomic DNA. Translation: ABF44938.1.
RefSeq	YP_604107.1. NC_008025.1.
3D structure databases
ProteinModelPortal	Q1J0P6.
ModBase	Search...
Protein-protein interaction databases
STRING	Q1J0P6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4057601.
GenomeReviews	Gene locus Dgeo_0636 in contig CP000359_GR.
KEGG	dge:Dgeo_0636.
NMPDR	fig|68909.1.peg.939.
PATRIC	21623123. VBIDeiGeo41128_1202.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0085.
HOGENOM	HBG285547.
OMA	HANEEIT.
PhylomeDB	Q1J0P6.
ProtClustDB	PRK00405.
Enzyme and pathway databases
BioCyc	DGEO319795:DGEO_0636-MONOMER.
Family and domain databases
HAMAP	MF_01321. RNApol_bact_RpoB. [Tree]
InterPro	IPR010243. DNA-dir_RNA_pol_bsu_bac-type. IPR019462. DNA-dir_RNA_pol_bsu_external_1. IPR015712. DNA-dir_RNA_pol_su2. IPR007120. DNA-dir_RNA_pol_su2_6. IPR007121. RNA_pol_bsu_CS. IPR007644. RNA_pol_bsu_protrusion. IPR007642. RNA_pol_Rpb2_2. IPR007645. RNA_pol_Rpb2_3. IPR007641. RNA_pol_Rpb2_7. IPR014724. RNA_pol_RPB2_OB-fold. [Graphical view]
Gene3D	G3DSA:2.30.150.10. G3DSA:2.30.150.10. 1 hit. G3DSA:2.40.270.10. G3DSA:2.40.270.10. 2 hits. G3DSA:2.40.50.150. Ribosomal_L2. 1 hit.
KO	K03043.
PANTHER	PTHR20856:SF3. PTHR20856:SF3. 1 hit. PTHR20856. RNA_pol_I_sub2. 1 hit.
Pfam	PF04563. RNA_pol_Rpb2_1. 1 hit. PF04561. RNA_pol_Rpb2_2. 1 hit. PF04565. RNA_pol_Rpb2_3. 1 hit. PF10385. RNA_pol_Rpb2_45. 1 hit. PF00562. RNA_pol_Rpb2_6. 1 hit. PF04560. RNA_pol_Rpb2_7. 1 hit. [Graphical view]
TIGRFAMs	TIGR02013. RpoB. 1 hit.
PROSITE	PS01166. RNA_POL_BETA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

RPOB_DEIGD

Accession

Primary (citable) accession number: Q1J0P6

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	June 13, 2006
Last modified:	January 25, 2012
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program