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Q1J0L2

- PANC_DEIGD

UniProt

Q1J0L2 - PANC_DEIGD

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Protein

Pantothenate synthetase

Gene

panC

Organism
Deinococcus geothermalis (strain DSM 11300)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.UniRule annotation

Catalytic activityi

ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei38 – 381Proton donorUniRule annotation
Binding sitei62 – 621Beta-alanineUniRule annotation
Binding sitei62 – 621PantoateUniRule annotation
Binding sitei154 – 1541PantoateUniRule annotation
Binding sitei177 – 1771ATP; via amide nitrogen and carbonyl oxygenUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi31 – 388ATPUniRule annotation
Nucleotide bindingi148 – 1514ATPUniRule annotation
Nucleotide bindingi185 – 1884ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. pantoate-beta-alanine ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. pantothenate biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Pantothenate biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciDGEO319795:GHMU-692-MONOMER.
UniPathwayiUPA00028; UER00005.

Names & Taxonomyi

Protein namesi
Recommended name:
Pantothenate synthetaseUniRule annotation (EC:6.3.2.1UniRule annotation)
Short name:
PSUniRule annotation
Alternative name(s):
Pantoate--beta-alanine ligaseUniRule annotation
Pantoate-activating enzymeUniRule annotation
Gene namesi
Name:panCUniRule annotation
Ordered Locus Names:Dgeo_0670
OrganismiDeinococcus geothermalis (strain DSM 11300)
Taxonomic identifieri319795 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciDeinococcalesDeinococcaceaeDeinococcus
ProteomesiUP000002431: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 296296Pantothenate synthetasePRO_0000305437Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi319795.Dgeo_0670.

Structurei

3D structure databases

ProteinModelPortaliQ1J0L2.
SMRiQ1J0L2. Positions 7-283.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the pantothenate synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0414.
HOGENOMiHOG000175516.
KOiK01918.
OMAiPTHFAGM.
OrthoDBiEOG6Z6FZ4.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00158. PanC.
InterProiIPR004821. Cyt_trans-like.
IPR003721. Pantoate_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERiPTHR21299:SF1. PTHR21299:SF1. 1 hit.
PfamiPF02569. Pantoate_ligase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00125. cyt_tran_rel. 1 hit.
TIGR00018. panC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1J0L2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNRTATRVLS SIEEVREALA GPGRVGLVPT MGYLHEGHAA LIRRARAECD
60 70 80 90 100
TVVLSVFVNP RQFGVNEDLS RYPRDLNRDL AVAEAAGADL LFHPDVATMY
110 120 130 140 150
PAGYATTVAV GGVSEPLEGS SRPGHFDGVA TVVLKLLNIV QPERAYFGEK
160 170 180 190 200
DWQQLAVVRR MVRDLNVPVQ IVGVPTVREP SGLALSSRNS YLTPEQQARA
210 220 230 240 250
AILSRALQAV QAAAAAGERD TARLRQAGLA VLAEEPEIEL DYLAVVDGDM
260 270 280 290
REKAHVENDP LTRVLVAARL FGVRLIDNVP LSPAERRLSE RESRNT
Length:296
Mass (Da):32,200
Last modified:June 13, 2006 - v1
Checksum:iE61DD67E15CF29C7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000359 Genomic DNA. Translation: ABF44972.1.
RefSeqiWP_011529813.1. NC_008025.1.
YP_604141.1. NC_008025.1.

Genome annotation databases

EnsemblBacteriaiABF44972; ABF44972; Dgeo_0670.
GeneIDi4058252.
KEGGidge:Dgeo_0670.
PATRICi21623201. VBIDeiGeo41128_1237.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000359 Genomic DNA. Translation: ABF44972.1 .
RefSeqi WP_011529813.1. NC_008025.1.
YP_604141.1. NC_008025.1.

3D structure databases

ProteinModelPortali Q1J0L2.
SMRi Q1J0L2. Positions 7-283.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 319795.Dgeo_0670.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABF44972 ; ABF44972 ; Dgeo_0670 .
GeneIDi 4058252.
KEGGi dge:Dgeo_0670.
PATRICi 21623201. VBIDeiGeo41128_1237.

Phylogenomic databases

eggNOGi COG0414.
HOGENOMi HOG000175516.
KOi K01918.
OMAi PTHFAGM.
OrthoDBi EOG6Z6FZ4.

Enzyme and pathway databases

UniPathwayi UPA00028 ; UER00005 .
BioCyci DGEO319795:GHMU-692-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
HAMAPi MF_00158. PanC.
InterProi IPR004821. Cyt_trans-like.
IPR003721. Pantoate_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
PANTHERi PTHR21299:SF1. PTHR21299:SF1. 1 hit.
Pfami PF02569. Pantoate_ligase. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00125. cyt_tran_rel. 1 hit.
TIGR00018. panC. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 11300.

Entry informationi

Entry nameiPANC_DEIGD
AccessioniPrimary (citable) accession number: Q1J0L2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: June 13, 2006
Last modified: October 29, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The reaction proceeds by a bi uni uni bi ping pong mechanism.UniRule annotation

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3