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Q1J0L2

- PANC_DEIGD

UniProt

Q1J0L2 - PANC_DEIGD

Protein

Pantothenate synthetase

Gene

panC

Organism
Deinococcus geothermalis (strain DSM 11300)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 1 (13 Jun 2006)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.UniRule annotation

    Catalytic activityi

    ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei38 – 381Proton donorUniRule annotation
    Binding sitei62 – 621Beta-alanineUniRule annotation
    Binding sitei62 – 621PantoateUniRule annotation
    Binding sitei154 – 1541PantoateUniRule annotation
    Binding sitei177 – 1771ATP; via amide nitrogen and carbonyl oxygenUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi31 – 388ATPUniRule annotation
    Nucleotide bindingi148 – 1514ATPUniRule annotation
    Nucleotide bindingi185 – 1884ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. pantoate-beta-alanine ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. pantothenate biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Pantothenate biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciDGEO319795:GHMU-692-MONOMER.
    UniPathwayiUPA00028; UER00005.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pantothenate synthetaseUniRule annotation (EC:6.3.2.1UniRule annotation)
    Short name:
    PSUniRule annotation
    Alternative name(s):
    Pantoate--beta-alanine ligaseUniRule annotation
    Pantoate-activating enzymeUniRule annotation
    Gene namesi
    Name:panCUniRule annotation
    Ordered Locus Names:Dgeo_0670
    OrganismiDeinococcus geothermalis (strain DSM 11300)
    Taxonomic identifieri319795 [NCBI]
    Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciDeinococcalesDeinococcaceaeDeinococcus
    ProteomesiUP000002431: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 296296Pantothenate synthetasePRO_0000305437Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi319795.Dgeo_0670.

    Structurei

    3D structure databases

    ProteinModelPortaliQ1J0L2.
    SMRiQ1J0L2. Positions 7-283.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the pantothenate synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0414.
    HOGENOMiHOG000175516.
    KOiK01918.
    OMAiPTHFAGM.
    OrthoDBiEOG6Z6FZ4.

    Family and domain databases

    Gene3Di3.40.50.620. 1 hit.
    HAMAPiMF_00158. PanC.
    InterProiIPR004821. Cyt_trans-like.
    IPR003721. Pantoate_ligase.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PANTHERiPTHR21299:SF1. PTHR21299:SF1. 1 hit.
    PfamiPF02569. Pantoate_ligase. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00125. cyt_tran_rel. 1 hit.
    TIGR00018. panC. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q1J0L2-1 [UniParc]FASTAAdd to Basket

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    MNRTATRVLS SIEEVREALA GPGRVGLVPT MGYLHEGHAA LIRRARAECD    50
    TVVLSVFVNP RQFGVNEDLS RYPRDLNRDL AVAEAAGADL LFHPDVATMY 100
    PAGYATTVAV GGVSEPLEGS SRPGHFDGVA TVVLKLLNIV QPERAYFGEK 150
    DWQQLAVVRR MVRDLNVPVQ IVGVPTVREP SGLALSSRNS YLTPEQQARA 200
    AILSRALQAV QAAAAAGERD TARLRQAGLA VLAEEPEIEL DYLAVVDGDM 250
    REKAHVENDP LTRVLVAARL FGVRLIDNVP LSPAERRLSE RESRNT 296
    Length:296
    Mass (Da):32,200
    Last modified:June 13, 2006 - v1
    Checksum:iE61DD67E15CF29C7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000359 Genomic DNA. Translation: ABF44972.1.
    RefSeqiWP_011529813.1. NC_008025.1.
    YP_604141.1. NC_008025.1.

    Genome annotation databases

    EnsemblBacteriaiABF44972; ABF44972; Dgeo_0670.
    GeneIDi4058252.
    KEGGidge:Dgeo_0670.
    PATRICi21623201. VBIDeiGeo41128_1237.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000359 Genomic DNA. Translation: ABF44972.1 .
    RefSeqi WP_011529813.1. NC_008025.1.
    YP_604141.1. NC_008025.1.

    3D structure databases

    ProteinModelPortali Q1J0L2.
    SMRi Q1J0L2. Positions 7-283.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 319795.Dgeo_0670.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABF44972 ; ABF44972 ; Dgeo_0670 .
    GeneIDi 4058252.
    KEGGi dge:Dgeo_0670.
    PATRICi 21623201. VBIDeiGeo41128_1237.

    Phylogenomic databases

    eggNOGi COG0414.
    HOGENOMi HOG000175516.
    KOi K01918.
    OMAi PTHFAGM.
    OrthoDBi EOG6Z6FZ4.

    Enzyme and pathway databases

    UniPathwayi UPA00028 ; UER00005 .
    BioCyci DGEO319795:GHMU-692-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.620. 1 hit.
    HAMAPi MF_00158. PanC.
    InterProi IPR004821. Cyt_trans-like.
    IPR003721. Pantoate_ligase.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    PANTHERi PTHR21299:SF1. PTHR21299:SF1. 1 hit.
    Pfami PF02569. Pantoate_ligase. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00125. cyt_tran_rel. 1 hit.
    TIGR00018. panC. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 11300.

    Entry informationi

    Entry nameiPANC_DEIGD
    AccessioniPrimary (citable) accession number: Q1J0L2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 2, 2007
    Last sequence update: June 13, 2006
    Last modified: October 1, 2014
    This is version 55 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    The reaction proceeds by a bi uni uni bi ping pong mechanism.UniRule annotation

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3