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Q1IZQ5 (HIS7_DEIGD) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Imidazoleglycerol-phosphate dehydratase
Short name=IGPD
EC=4.2.1.19
Gene names
Name:hisB
Ordered Locus Names:Dgeo_0979
OrganismDeinococcus geothermalis (strain DSM 11300) [Complete proteome] [HAMAP]
Taxonomic identifier319795 [NCBI]
Taxonomic lineageBacteria › Deinococcus-Thermus › Deinococci › Deinococcales › Deinococcaceae › Deinococcus ›

Protein attributes

Sequence length203 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O. HAMAP-Rule MF_00076

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 6/9. HAMAP-Rule MF_00076

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the imidazoleglycerol-phosphate dehydratase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Histidine biosynthesis
   Cellular componentCytoplasm
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processhistidine biosynthetic process

Inferred from electronic annotation. Source: HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionimidazoleglycerol-phosphate dehydratase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 203203Imidazoleglycerol-phosphate dehydratase HAMAP-Rule MF_00076
PRO_0000336309

Sequences

Sequence LengthMass (Da)Tools
Q1IZQ5 [UniParc].

Last modified June 13, 2006. Version 1.
Checksum: 22DD3EEC8B3B1250

FASTA20322,243
        10         20         30         40         50         60 
MRLMARTATN RTATVRRTTK ETDITVTLDL DSPVSTPPTT GHGFLDHMLD ALARHGRLGL 

        70         80         90        100        110        120 
SVRATGDLHI EPHHLIEDVG ITLGQALNQA LGGRRGIERY GSAFVPMDET LAHVVLDLSG 

       130        140        150        160        170        180 
RAHLAFEPER LDVWGDAGGM THYHLREFLR GFCNHAGVTL HVRLLAGREA HHVIEAMVKA 

       190        200 
FARALRDAVR VTSEELASTK GLL

« Hide

References

[1]"Complete sequence of chromosome 1 of Deinococcus geothermalis DSM 11300."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Brettin T., Bruce D., Han C., Tapia R., Saunders E., Gilna P., Schmutz J. expand/collapse author list , Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Daly M.J., Fredrickson J.K., Makarova K.S., Gaidamakova E.K., Zhai M., Richardson P.
Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 11300.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000359 Genomic DNA. Translation: ABF45279.1.
RefSeqYP_604448.1. NC_008025.1.

3D structure databases

ProteinModelPortalQ1IZQ5.
ModBaseSearch...

Protein-protein interaction databases

STRING319795.Dgeo_0979.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABF45279; ABF45279; Dgeo_0979.
GeneID4058676.
KEGGdge:Dgeo_0979.
PATRIC21623843. VBIDeiGeo41128_1558.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0131.
HOGENOMHOG000228064.
KOK01693.
OMASTENVVH.
ProtClustDBCLSK444524.

Enzyme and pathway databases

BioCycDGEO319795:GHMU-1249-MONOMER.
UniPathwayUPA00031; UER00011.

Family and domain databases

HAMAPMF_00076. HisB.
InterProIPR000807. ImidazoleglycerolP_deHydtase.
IPR020565. ImidazoleglycerP_deHydtase_CS.
IPR020568. Ribosomal_S5_D2-typ_fold.
[Graphical view]
PANTHERPTHR23133:SF2. PTHR23133:SF2. 1 hit.
PfamPF00475. IGPD. 1 hit.
[Graphical view]
SUPFAMSSF54211. Ribosomal_S5_D2-typ_fold. 2 hits.
PROSITEPS00954. IGP_DEHYDRATASE_1. 1 hit.
PS00955. IGP_DEHYDRATASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHIS7_DEIGD
AccessionPrimary (citable) accession number: Q1IZQ5
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: June 13, 2006
Last modified: May 1, 2013
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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