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Q1IZQ5

- HIS7_DEIGD

UniProt

Q1IZQ5 - HIS7_DEIGD

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Protein
Imidazoleglycerol-phosphate dehydratase
Gene
hisB, Dgeo_0979
Organism
Deinococcus geothermalis (strain DSM 11300)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. imidazoleglycerol-phosphate dehydratase activity Source: UniProtKB-EC

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Enzyme and pathway databases

BioCyciDGEO319795:GHMU-1001-MONOMER.
UniPathwayiUPA00031; UER00011.

Names & Taxonomyi

Protein namesi
Recommended name:
Imidazoleglycerol-phosphate dehydratase (EC:4.2.1.19)
Short name:
IGPD
Gene namesi
Name:hisB
Ordered Locus Names:Dgeo_0979
OrganismiDeinococcus geothermalis (strain DSM 11300)
Taxonomic identifieri319795 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciDeinococcalesDeinococcaceaeDeinococcus
ProteomesiUP000002431: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 203203Imidazoleglycerol-phosphate dehydrataseUniRule annotation
PRO_0000336309Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi319795.Dgeo_0979.

Structurei

3D structure databases

ProteinModelPortaliQ1IZQ5.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0131.
HOGENOMiHOG000228064.
KOiK01693.
OMAiLTHMVET.
OrthoDBiEOG60PHGP.

Family and domain databases

HAMAPiMF_00076. HisB.
InterProiIPR000807. ImidazoleglycerolP_deHydtase.
IPR020565. ImidazoleglycerP_deHydtase_CS.
IPR020568. Ribosomal_S5_D2-typ_fold.
[Graphical view]
PANTHERiPTHR23133:SF2. PTHR23133:SF2. 1 hit.
PfamiPF00475. IGPD. 1 hit.
[Graphical view]
SUPFAMiSSF54211. SSF54211. 2 hits.
PROSITEiPS00954. IGP_DEHYDRATASE_1. 1 hit.
PS00955. IGP_DEHYDRATASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1IZQ5-1 [UniParc]FASTAAdd to Basket

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MRLMARTATN RTATVRRTTK ETDITVTLDL DSPVSTPPTT GHGFLDHMLD    50
ALARHGRLGL SVRATGDLHI EPHHLIEDVG ITLGQALNQA LGGRRGIERY 100
GSAFVPMDET LAHVVLDLSG RAHLAFEPER LDVWGDAGGM THYHLREFLR 150
GFCNHAGVTL HVRLLAGREA HHVIEAMVKA FARALRDAVR VTSEELASTK 200
GLL 203
Length:203
Mass (Da):22,243
Last modified:June 13, 2006 - v1
Checksum:i22DD3EEC8B3B1250
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000359 Genomic DNA. Translation: ABF45279.1.
RefSeqiYP_604448.1. NC_008025.1.

Genome annotation databases

EnsemblBacteriaiABF45279; ABF45279; Dgeo_0979.
GeneIDi4058676.
KEGGidge:Dgeo_0979.
PATRICi21623843. VBIDeiGeo41128_1558.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000359 Genomic DNA. Translation: ABF45279.1 .
RefSeqi YP_604448.1. NC_008025.1.

3D structure databases

ProteinModelPortali Q1IZQ5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 319795.Dgeo_0979.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABF45279 ; ABF45279 ; Dgeo_0979 .
GeneIDi 4058676.
KEGGi dge:Dgeo_0979.
PATRICi 21623843. VBIDeiGeo41128_1558.

Phylogenomic databases

eggNOGi COG0131.
HOGENOMi HOG000228064.
KOi K01693.
OMAi LTHMVET.
OrthoDBi EOG60PHGP.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00011 .
BioCyci DGEO319795:GHMU-1001-MONOMER.

Family and domain databases

HAMAPi MF_00076. HisB.
InterProi IPR000807. ImidazoleglycerolP_deHydtase.
IPR020565. ImidazoleglycerP_deHydtase_CS.
IPR020568. Ribosomal_S5_D2-typ_fold.
[Graphical view ]
PANTHERi PTHR23133:SF2. PTHR23133:SF2. 1 hit.
Pfami PF00475. IGPD. 1 hit.
[Graphical view ]
SUPFAMi SSF54211. SSF54211. 2 hits.
PROSITEi PS00954. IGP_DEHYDRATASE_1. 1 hit.
PS00955. IGP_DEHYDRATASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 11300.

Entry informationi

Entry nameiHIS7_DEIGD
AccessioniPrimary (citable) accession number: Q1IZQ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: June 13, 2006
Last modified: May 14, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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