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Q1IZQ5

- HIS7_DEIGD

UniProt

Q1IZQ5 - HIS7_DEIGD

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Protein

Imidazoleglycerol-phosphate dehydratase

Gene

hisB

Organism
Deinococcus geothermalis (strain DSM 11300)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. imidazoleglycerol-phosphate dehydratase activity Source: UniProtKB-EC

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Enzyme and pathway databases

BioCyciDGEO319795:GHMU-1001-MONOMER.
UniPathwayiUPA00031; UER00011.

Names & Taxonomyi

Protein namesi
Recommended name:
Imidazoleglycerol-phosphate dehydrataseUniRule annotation (EC:4.2.1.19UniRule annotation)
Short name:
IGPDUniRule annotation
Gene namesi
Name:hisBUniRule annotation
Ordered Locus Names:Dgeo_0979
OrganismiDeinococcus geothermalis (strain DSM 11300)
Taxonomic identifieri319795 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciDeinococcalesDeinococcaceaeDeinococcus
ProteomesiUP000002431: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 203203Imidazoleglycerol-phosphate dehydratasePRO_0000336309Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi319795.Dgeo_0979.

Structurei

3D structure databases

ProteinModelPortaliQ1IZQ5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the imidazoleglycerol-phosphate dehydratase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0131.
HOGENOMiHOG000228064.
KOiK01693.
OMAiLTHMVET.
OrthoDBiEOG60PHGP.

Family and domain databases

HAMAPiMF_00076. HisB.
InterProiIPR000807. ImidazoleglycerolP_deHydtase.
IPR020565. ImidazoleglycerP_deHydtase_CS.
IPR020568. Ribosomal_S5_D2-typ_fold.
[Graphical view]
PANTHERiPTHR23133:SF2. PTHR23133:SF2. 1 hit.
PfamiPF00475. IGPD. 1 hit.
[Graphical view]
SUPFAMiSSF54211. SSF54211. 2 hits.
PROSITEiPS00954. IGP_DEHYDRATASE_1. 1 hit.
PS00955. IGP_DEHYDRATASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1IZQ5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRLMARTATN RTATVRRTTK ETDITVTLDL DSPVSTPPTT GHGFLDHMLD
60 70 80 90 100
ALARHGRLGL SVRATGDLHI EPHHLIEDVG ITLGQALNQA LGGRRGIERY
110 120 130 140 150
GSAFVPMDET LAHVVLDLSG RAHLAFEPER LDVWGDAGGM THYHLREFLR
160 170 180 190 200
GFCNHAGVTL HVRLLAGREA HHVIEAMVKA FARALRDAVR VTSEELASTK

GLL
Length:203
Mass (Da):22,243
Last modified:June 13, 2006 - v1
Checksum:i22DD3EEC8B3B1250
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000359 Genomic DNA. Translation: ABF45279.1.
RefSeqiYP_604448.1. NC_008025.1.

Genome annotation databases

EnsemblBacteriaiABF45279; ABF45279; Dgeo_0979.
GeneIDi4058676.
KEGGidge:Dgeo_0979.
PATRICi21623843. VBIDeiGeo41128_1558.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000359 Genomic DNA. Translation: ABF45279.1 .
RefSeqi YP_604448.1. NC_008025.1.

3D structure databases

ProteinModelPortali Q1IZQ5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 319795.Dgeo_0979.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABF45279 ; ABF45279 ; Dgeo_0979 .
GeneIDi 4058676.
KEGGi dge:Dgeo_0979.
PATRICi 21623843. VBIDeiGeo41128_1558.

Phylogenomic databases

eggNOGi COG0131.
HOGENOMi HOG000228064.
KOi K01693.
OMAi LTHMVET.
OrthoDBi EOG60PHGP.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00011 .
BioCyci DGEO319795:GHMU-1001-MONOMER.

Family and domain databases

HAMAPi MF_00076. HisB.
InterProi IPR000807. ImidazoleglycerolP_deHydtase.
IPR020565. ImidazoleglycerP_deHydtase_CS.
IPR020568. Ribosomal_S5_D2-typ_fold.
[Graphical view ]
PANTHERi PTHR23133:SF2. PTHR23133:SF2. 1 hit.
Pfami PF00475. IGPD. 1 hit.
[Graphical view ]
SUPFAMi SSF54211. SSF54211. 2 hits.
PROSITEi PS00954. IGP_DEHYDRATASE_1. 1 hit.
PS00955. IGP_DEHYDRATASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 11300.

Entry informationi

Entry nameiHIS7_DEIGD
AccessioniPrimary (citable) accession number: Q1IZQ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: June 13, 2006
Last modified: October 29, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3