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Q1IZI4 (UPPP_DEIGD) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Ordered Locus Names:Dgeo_1051
OrganismDeinococcus geothermalis (strain DSM 11300) [Complete proteome] [HAMAP]
Taxonomic identifier319795 [NCBI]
Taxonomic lineageBacteriaDeinococcus-ThermusDeinococciDeinococcalesDeinococcaceaeDeinococcus

Protein attributes

Sequence length274 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 274274Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_0000250233

Regions

Transmembrane1 – 2121Helical; Potential
Transmembrane48 – 6821Helical; Potential
Transmembrane84 – 10421Helical; Potential
Transmembrane108 – 12821Helical; Potential
Transmembrane143 – 16321Helical; Potential
Transmembrane187 – 20721Helical; Potential
Transmembrane214 – 23421Helical; Potential
Transmembrane254 – 27421Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q1IZI4 [UniParc].

Last modified June 13, 2006. Version 1.
Checksum: F488DD3D067D834C

FASTA27429,667
        10         20         30         40         50         60 
MDWFYAIIYG IVEGITEFLP ISSTGHLIVA GNLMGVPWSK EIRDTFEVVI QGGAILAVLA 

        70         80         90        100        110        120 
YYWRDFAGQA RVIGHDRPTQ RLWLGVIVGV IPAVVLGVLF GDVIKAHLFR PSVVAWALIV 

       130        140        150        160        170        180 
GGVLMWVIEN RKAPPVVHDL KQIGLGRAFL IGAAQCLALL WPGFSRSASS ILGGMVMGLD 

       190        200        210        220        230        240 
RPTATRFSFY LGIPTLGGAA LLDFIKSRHL LAEIGLLNVF LGAAVSFVVA YLAIGWLLRF 

       250        260        270 
VSQHNFKGFA VYRVIFGLLI LLLVASGRLA NGGL 

« Hide

References

[1]"Complete sequence of chromosome 1 of Deinococcus geothermalis DSM 11300."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Brettin T., Bruce D., Han C., Tapia R., Saunders E., Gilna P., Schmutz J. expand/collapse author list , Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Daly M.J., Fredrickson J.K., Makarova K.S., Gaidamakova E.K., Zhai M., Richardson P.
Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 11300.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000359 Genomic DNA. Translation: ABF45350.1.
RefSeqYP_604519.1. NC_008025.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING319795.Dgeo_1051.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABF45350; ABF45350; Dgeo_1051.
GeneID4057836.
KEGGdge:Dgeo_1051.
PATRIC21623985. VBIDeiGeo41128_1629.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218356.
KOK06153.
OMAAQCFALI.
OrthoDBEOG6QP13M.
ProtClustDBCLSK444548.

Enzyme and pathway databases

BioCycDGEO319795:GHMU-1073-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsTIGR00753. undec_PP_bacA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameUPPP_DEIGD
AccessionPrimary (citable) accession number: Q1IZI4
Entry history
Integrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: June 13, 2006
Last modified: February 19, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families