Reviewed, UniProtKB/Swiss-Prot Q1IZA1 (SYN_DEIGD)

Names and origin

Protein names

Recommended name:
    Asparaginyl-tRNA synthetase
    EC=6.1.1.22
Alternative name(s):
    Asparagine--tRNA ligase
      Short name=AsnRS

Gene names

Name:	asnS
Ordered Locus Names:	Dgeo_1136

Organism

Deinococcus geothermalis (strain DSM 11300) [Complete proteome] [HAMAP]

Taxonomic identifier

319795 [NCBI]

Taxonomic lineage

Bacteria › Deinococcus-Thermus › Deinococci › Deinococcales › Deinococcaceae › Deinococcus

Protein attributes

Sequence length	449 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + L-asparagine + tRNA(Asn) = AMP + diphosphate + L-asparaginyl-tRNA(Asn). HAMAP MF_00534
Subunit structure	Homodimer By similarity. HAMAP MF_00534
Subcellular location	Cytoplasm By similarity HAMAP MF_00534.
Sequence similarities	Belongs to the class-II aminoacyl-tRNA synthetase family.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Aminoacyl-tRNA synthetase Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	asparaginyl-tRNA aminoacylation Inferred from electronic annotation. Source: HAMAP aspartyl-tRNA aminoacylation Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP asparagine-tRNA ligase activity Inferred from electronic annotation. Source: HAMAP aspartate-tRNA ligase activity Inferred from electronic annotation. Source: InterPro nucleic acid binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 449	449	Asparaginyl-tRNA synthetase HAMAP MF_00534		PRO_1000081847

Sequences

	Sequence		Length	Mass (Da)
	Q1IZA1-1 [UniParc]. Last modified June 13, 2006. Version 1. Checksum: 2886179F29A6AFF2	FASTA	449	50,633
	10 20 30 40 50 60 MTVIPNVSID ALKNHVGETV RVNAWLTDKS GKGKLQFLKL RDGSGFVQAT VFKGDVPEEV 70 80 90 100 110 120 FEAARRLSQE QAVRVTGEVR ADERAPGGVE LAVRDLVPFA ANQAEYPITP KEHGIEFLLD 130 140 150 160 170 180 HRHLWLRHRR PWAILRVRDC VERAIVEFFH QEGFIRFDAP FFTPNAAEGT TELFEIDLFG 190 200 210 220 230 240 EDKAYLSQTG QLHAEAGALA FGKVYTFGPT FRAEKSKTRR HLLEFWMVEP EVAPATHQDN 250 260 270 280 290 300 MDLQERLVSF LVRRVLEECA AELAVLGRDV AKLQPAAEGN YPRVTYTEAL DIIRRHIAEG 310 320 330 340 350 360 DLPPNVQPDV QPVEWGDDLG APHETILGFH FDRPVIVERY PAAIKAFYMQ PDPADPRLAL 370 380 390 400 410 420 CDDMIAPEGY GEIIGGSERI HDYTLLKARI EGEGLPLSAF DWYLDLRRFG SVPHAGFGMG 430 440 LERVIAWITG IDHIREAIPF PRMLTRMVP

References

[1]

"Complete sequence of chromosome 1 of Deinococcus geothermalis DSM 11300." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Brettin T., Bruce D., Han C., Tapia R., Saunders E., Gilna P., Schmutz J. , Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Daly M.J., Fredrickson J.K., Makarova K.S., Gaidamakova E.K., Zhai M., Richardson P. Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000359 Genomic DNA. Translation: ABF45433.1.
RefSeq	YP_604602.1.
3D structure databases
SMR	Q1IZA1. Positions 12-449.
ModBase	Search...
Protein-protein interaction databases
STRING	Q1IZA1.
Genome annotation databases
GeneID	4058304.
GenomeReviews	Gene locus Dgeo_1136 in contig CP000359_GR.
KEGG	dge:Dgeo_1136.
NMPDR	fig|68909.1.peg.2106.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0017.
HOGENOM	HBG745843.
OMA	LQKKRHS.
PhylomeDB	Q1IZA1.
Enzyme and pathway databases
BioCyc	DGEO319795:DGEO_1136-MONOMER.
Family and domain databases
HAMAP	MF_00534. Asn_tRNA_synth. [Tree]
InterPro	IPR004364. aa-tRNA-synt_II. IPR018150. aa-tRNA-synt_II-like. IPR006195. aa-tRNA-synth_II_cons-dom. IPR004522. Asn-tRNA-synth_IIb. IPR002312. Asp-tRNA-synth_IIb. IPR016027. NA-bd_OB-fold-like. IPR004365. NA_bd_OB_tRNA-helicase. [Graphical view]
PANTHER	PTHR22594. aa-tRNA-synt_II. 1 hit.
Pfam	PF00152. tRNA-synt_2. 1 hit. PF01336. tRNA_anti. 1 hit. [Graphical view]
PRINTS	PR01042. TRNASYNTHASP.
TIGRFAMs	TIGR00457. asnS. 1 hit.
PROSITE	PS50862. AA_TRNA_LIGASE_II. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SYN_DEIGD

Accession

Primary (citable) accession number: Q1IZA1

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	June 13, 2006
Last modified:	February 9, 2010
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)