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Protein

Glucose-6-phosphate isomerase

Gene

pgi

Organism
Deinococcus geothermalis (strain DSM 11300)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei370 – 3701Proton donorUniRule annotation
Active sitei401 – 4011UniRule annotation
Active sitei526 – 5261UniRule annotation

GO - Molecular functioni

  1. glucose-6-phosphate isomerase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. gluconeogenesis Source: UniProtKB-HAMAP
  2. glycolytic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Gluconeogenesis, Glycolysis

Enzyme and pathway databases

BioCyciDGEO319795:GHMU-1326-MONOMER.
UniPathwayiUPA00109; UER00181.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomeraseUniRule annotation (EC:5.3.1.9UniRule annotation)
Short name:
GPIUniRule annotation
Alternative name(s):
Phosphoglucose isomeraseUniRule annotation
Short name:
PGIUniRule annotation
Phosphohexose isomeraseUniRule annotation
Short name:
PHIUniRule annotation
Gene namesi
Name:pgiUniRule annotation
Ordered Locus Names:Dgeo_1304
OrganismiDeinococcus geothermalis (strain DSM 11300)
Taxonomic identifieri319795 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciDeinococcalesDeinococcaceaeDeinococcus
ProteomesiUP000002431: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 562562Glucose-6-phosphate isomerasePRO_0000252617Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi319795.Dgeo_1304.

Structurei

3D structure databases

ProteinModelPortaliQ1IYT4.
SMRiQ1IYT4. Positions 11-562.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0166.
HOGENOMiHOG000261371.
KOiK01810.
OrthoDBiEOG64R61J.

Family and domain databases

Gene3Di1.10.1390.10. 1 hit.
HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1IYT4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRDSSSPARP SLTQLPAWQA LKSHFETMRD RHLRDLFAAD PRRGERLVAE
60 70 80 90 100
GAGVYLDYSK NRITDETLRL LLQLAREAGV EARRDAMFAG ERINLTENRA
110 120 130 140 150
VLHSALRAPR GAAVTVDGTN VVQEVQEVLD RMSAFADRVR AGTWLGATGK
160 170 180 190 200
PIRNIVNIGI GGSDLGPVMA YEALKFYADR RLTLRFVSNV DGTDLVEKTR
210 220 230 240 250
DLDPAETLFI VSSKTFTTLE TMANAQSARA WLLAGLENVP DENAAIARPI
260 270 280 290 300
ISRHFVAVST NAAEVERFGI DTANMFGFWD WVGGRYSVDS AIGLSLMIAI
310 320 330 340 350
GPNGFRDFLA GFHAMDEHFR SAPLEQNLPV LLGVLGVWYR NFFGAQTYAV
360 370 380 390 400
LPYDQYLAYF PTYLQQLDME SNGKHVTLDG QPVDYDTGPV VWGQPGTNGQ
410 420 430 440 450
HAFYQLIHQG TTLIPCDFLG FCQTLNPLPT PGGPSHHDLL MANMFAQTEA
460 470 480 490 500
LAFGKSLEQV QAEGVAADLA PHRVFEGNRP TNTLLLDRLT PRTLGTLIAL
510 520 530 540 550
YEHKVFVQGA IWNINSFDQW GVELGKVLAS KIVPELEAPG EPELKHDSST
560
NALIRRYRAR RR
Length:562
Mass (Da):62,251
Last modified:October 17, 2006 - v2
Checksum:i5B1347A844609083
GO

Sequence cautioni

The sequence ABF45600.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000359 Genomic DNA. Translation: ABF45600.1. Different initiation.
RefSeqiYP_604769.1. NC_008025.1.

Genome annotation databases

EnsemblBacteriaiABF45600; ABF45600; Dgeo_1304.
GeneIDi4057074.
KEGGidge:Dgeo_1304.
PATRICi21624507. VBIDeiGeo41128_1890.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000359 Genomic DNA. Translation: ABF45600.1. Different initiation.
RefSeqiYP_604769.1. NC_008025.1.

3D structure databases

ProteinModelPortaliQ1IYT4.
SMRiQ1IYT4. Positions 11-562.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi319795.Dgeo_1304.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABF45600; ABF45600; Dgeo_1304.
GeneIDi4057074.
KEGGidge:Dgeo_1304.
PATRICi21624507. VBIDeiGeo41128_1890.

Phylogenomic databases

eggNOGiCOG0166.
HOGENOMiHOG000261371.
KOiK01810.
OrthoDBiEOG64R61J.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00181.
BioCyciDGEO319795:GHMU-1326-MONOMER.

Family and domain databases

Gene3Di1.10.1390.10. 1 hit.
HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 11300.

Entry informationi

Entry nameiG6PI_DEIGD
AccessioniPrimary (citable) accession number: Q1IYT4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: October 17, 2006
Last modified: January 7, 2015
This is version 52 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.