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Protein

Glucose-6-phosphate isomerase

Gene

pgi

Organism
Deinococcus geothermalis (strain DSM 11300)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.UniRule annotation

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.UniRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase (pgi)
  3. ATP-dependent 6-phosphofructokinase (pfkA)
  4. no protein annotated in this organism
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei370Proton donorUniRule annotation1
Active sitei401UniRule annotation1
Active sitei526UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processGluconeogenesis, Glycolysis

Enzyme and pathway databases

UniPathwayiUPA00109; UER00181

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomeraseUniRule annotation (EC:5.3.1.9UniRule annotation)
Short name:
GPIUniRule annotation
Alternative name(s):
Phosphoglucose isomeraseUniRule annotation
Short name:
PGIUniRule annotation
Phosphohexose isomeraseUniRule annotation
Short name:
PHIUniRule annotation
Gene namesi
Name:pgiUniRule annotation
Ordered Locus Names:Dgeo_1304
OrganismiDeinococcus geothermalis (strain DSM 11300)
Taxonomic identifieri319795 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciDeinococcalesDeinococcaceaeDeinococcus
Proteomesi
  • UP000002431 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002526171 – 562Glucose-6-phosphate isomeraseAdd BLAST562

Proteomic databases

PRIDEiQ1IYT4

Interactioni

Protein-protein interaction databases

STRINGi319795.Dgeo_1304

Structurei

3D structure databases

ProteinModelPortaliQ1IYT4
SMRiQ1IYT4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C89 Bacteria
COG0166 LUCA
HOGENOMiHOG000261371
KOiK01810
OrthoDBiPOG091H04C3

Family and domain databases

CDDicd05015 SIS_PGI_1, 1 hit
cd05016 SIS_PGI_2, 1 hit
Gene3Di1.10.1390.10, 1 hit
HAMAPiMF_00473 G6P_isomerase, 1 hit
InterProiView protein in InterPro
IPR001672 G6P_Isomerase
IPR023096 G6P_Isomerase_C
IPR018189 Phosphoglucose_isomerase_CS
IPR035476 SIS_PGI_1
IPR035482 SIS_PGI_2
PANTHERiPTHR11469 PTHR11469, 1 hit
PfamiView protein in Pfam
PF00342 PGI, 1 hit
PRINTSiPR00662 G6PISOMERASE
PROSITEiView protein in PROSITE
PS00765 P_GLUCOSE_ISOMERASE_1, 1 hit
PS00174 P_GLUCOSE_ISOMERASE_2, 1 hit
PS51463 P_GLUCOSE_ISOMERASE_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q1IYT4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRDSSSPARP SLTQLPAWQA LKSHFETMRD RHLRDLFAAD PRRGERLVAE
60 70 80 90 100
GAGVYLDYSK NRITDETLRL LLQLAREAGV EARRDAMFAG ERINLTENRA
110 120 130 140 150
VLHSALRAPR GAAVTVDGTN VVQEVQEVLD RMSAFADRVR AGTWLGATGK
160 170 180 190 200
PIRNIVNIGI GGSDLGPVMA YEALKFYADR RLTLRFVSNV DGTDLVEKTR
210 220 230 240 250
DLDPAETLFI VSSKTFTTLE TMANAQSARA WLLAGLENVP DENAAIARPI
260 270 280 290 300
ISRHFVAVST NAAEVERFGI DTANMFGFWD WVGGRYSVDS AIGLSLMIAI
310 320 330 340 350
GPNGFRDFLA GFHAMDEHFR SAPLEQNLPV LLGVLGVWYR NFFGAQTYAV
360 370 380 390 400
LPYDQYLAYF PTYLQQLDME SNGKHVTLDG QPVDYDTGPV VWGQPGTNGQ
410 420 430 440 450
HAFYQLIHQG TTLIPCDFLG FCQTLNPLPT PGGPSHHDLL MANMFAQTEA
460 470 480 490 500
LAFGKSLEQV QAEGVAADLA PHRVFEGNRP TNTLLLDRLT PRTLGTLIAL
510 520 530 540 550
YEHKVFVQGA IWNINSFDQW GVELGKVLAS KIVPELEAPG EPELKHDSST
560
NALIRRYRAR RR
Length:562
Mass (Da):62,251
Last modified:October 17, 2006 - v2
Checksum:i5B1347A844609083
GO

Sequence cautioni

The sequence ABF45600 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000359 Genomic DNA Translation: ABF45600.1 Different initiation.
RefSeqiWP_041221160.1, NC_008025.1

Genome annotation databases

EnsemblBacteriaiABF45600; ABF45600; Dgeo_1304
KEGGidge:Dgeo_1304

Similar proteinsi

Entry informationi

Entry nameiG6PI_DEIGD
AccessioniPrimary (citable) accession number: Q1IYT4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: October 17, 2006
Last modified: May 23, 2018
This is version 67 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health