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Q1IYA3 (TRMD_DEIGD) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
tRNA (guanine-N(1)-)-methyltransferase

EC=2.1.1.228
Alternative name(s):
M1G-methyltransferase
tRNA [GM37] methyltransferase
Gene names
Name:trmD
Ordered Locus Names:Dgeo_1486
OrganismDeinococcus geothermalis (strain DSM 11300) [Complete proteome] [HAMAP]
Taxonomic identifier319795 [NCBI]
Taxonomic lineageBacteriaDeinococcus-ThermusDeinococciDeinococcalesDeinococcaceaeDeinococcus

Protein attributes

Sequence length265 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Specifically methylates guanosine-37 in various tRNAs By similarity. HAMAP-Rule MF_00605

Catalytic activity

S-adenosyl-L-methionine + guanine37 in tRNA = S-adenosyl-L-homocysteine + N(1)-methylguanine37 in tRNA. HAMAP-Rule MF_00605

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00605

Subcellular location

Cytoplasm Potential HAMAP-Rule MF_00605.

Sequence similarities

Belongs to the RNA methyltransferase TrmD family.

Ontologies

Keywords
   Biological processtRNA processing
   Cellular componentCytoplasm
   LigandS-adenosyl-L-methionine
   Molecular functionMethyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functiontRNA (guanine(37)-N(1))-methyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 265265tRNA (guanine-N(1)-)-methyltransferase HAMAP-Rule MF_00605
PRO_0000257413

Regions

Region129 – 1346S-adenosyl-L-methionine binding By similarity

Sites

Binding site1101S-adenosyl-L-methionine; via amide nitrogen By similarity

Sequences

Sequence LengthMass (Da)Tools
Q1IYA3 [UniParc].

Last modified June 13, 2006. Version 1.
Checksum: CAE80C3A93B89808

FASTA26528,752
        10         20         30         40         50         60 
MLTFSFLTLF PELLAPFASE ALVGKARARG LLDVQLVNMR DFAENKHLKV DDTPYGGGAG 

        70         80         90        100        110        120 
MVIRVDVVER ALASLPPADE VILLTPAGER FTQQMAEELS RTTHLAFLCG RYEGFDARVE 

       130        140        150        160        170        180 
RLATRELSLG DFVMMGGEAA AACVLEAVAR LVPGVLGDED SHRADSFSSG LLDYPEYTRP 

       190        200        210        220        230        240 
AEWRGEGVPE VLKGGNHAAV ARWRREQALA RTLARRPDLL PSAGLTPQDS AYLLTLGVTP 

       250        260 
EQLAAWGAPP PPLPKRRRGA KPNPN 

« Hide

References

[1]"Complete sequence of chromosome 1 of Deinococcus geothermalis DSM 11300."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Brettin T., Bruce D., Han C., Tapia R., Saunders E., Gilna P., Schmutz J. expand/collapse author list , Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Daly M.J., Fredrickson J.K., Makarova K.S., Gaidamakova E.K., Zhai M., Richardson P.
Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 11300.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000359 Genomic DNA. Translation: ABF45781.1.
RefSeqYP_604950.1. NC_008025.1.

3D structure databases

ProteinModelPortalQ1IYA3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING319795.Dgeo_1486.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABF45781; ABF45781; Dgeo_1486.
GeneID4057372.
KEGGdge:Dgeo_1486.
PATRIC21624889. VBIDeiGeo41128_2076.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0336.
HOGENOMHOG000016242.
KOK00554.
OMAWRGHEVP.
OrthoDBEOG6J48RZ.

Enzyme and pathway databases

BioCycDGEO319795:GHMU-1512-MONOMER.

Family and domain databases

Gene3D1.10.1270.20. 1 hit.
3.40.1280.10. 1 hit.
HAMAPMF_00605. TrmD.
InterProIPR029028. Alpha/beta_knot_MTases.
IPR002649. tRNA_m1G_MeTrfase_bac.
IPR023148. tRNA_m1G_MeTrfase_C.
IPR029026. tRNA_m1G_MTases_N.
IPR016009. tRNA_MeTrfase_TRMD/TRM10.
[Graphical view]
PfamPF01746. tRNA_m1G_MT. 1 hit.
[Graphical view]
PIRSFPIRSF000386. tRNA_mtase. 1 hit.
SUPFAMSSF75217. SSF75217. 1 hit.
TIGRFAMsTIGR00088. trmD. 1 hit.
ProtoNetSearch...

Entry information

Entry nameTRMD_DEIGD
AccessionPrimary (citable) accession number: Q1IYA3
Entry history
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: June 13, 2006
Last modified: June 11, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families