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Q1IYA3

- TRMD_DEIGD

UniProt

Q1IYA3 - TRMD_DEIGD

Protein

tRNA (guanine-N(1)-)-methyltransferase

Gene

trmD

Organism
Deinococcus geothermalis (strain DSM 11300)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 1 (13 Jun 2006)
      Previous versions | rss
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    Functioni

    Specifically methylates guanosine-37 in various tRNAs.UniRule annotation

    Catalytic activityi

    S-adenosyl-L-methionine + guanine(37) in tRNA = S-adenosyl-L-homocysteine + N(1)-methylguanine(37) in tRNA.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei110 – 1101S-adenosyl-L-methionine; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. tRNA (guanine(37)-N(1))-methyltransferase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    tRNA processing

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Enzyme and pathway databases

    BioCyciDGEO319795:GHMU-1512-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    tRNA (guanine-N(1)-)-methyltransferaseUniRule annotation (EC:2.1.1.228UniRule annotation)
    Alternative name(s):
    M1G-methyltransferaseUniRule annotation
    tRNA [GM37] methyltransferaseUniRule annotation
    Gene namesi
    Name:trmDUniRule annotation
    Ordered Locus Names:Dgeo_1486
    OrganismiDeinococcus geothermalis (strain DSM 11300)
    Taxonomic identifieri319795 [NCBI]
    Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciDeinococcalesDeinococcaceaeDeinococcus
    ProteomesiUP000002431: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 265265tRNA (guanine-N(1)-)-methyltransferasePRO_0000257413Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi319795.Dgeo_1486.

    Structurei

    3D structure databases

    ProteinModelPortaliQ1IYA3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni129 – 1346S-adenosyl-L-methionine bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the RNA methyltransferase TrmD family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0336.
    HOGENOMiHOG000016242.
    KOiK00554.
    OMAiWRGHEVP.
    OrthoDBiEOG6J48RZ.

    Family and domain databases

    Gene3Di1.10.1270.20. 1 hit.
    3.40.1280.10. 1 hit.
    HAMAPiMF_00605. TrmD.
    InterProiIPR029028. Alpha/beta_knot_MTases.
    IPR002649. tRNA_m1G_MeTrfase_bac.
    IPR023148. tRNA_m1G_MeTrfase_C.
    IPR029026. tRNA_m1G_MTases_N.
    IPR016009. tRNA_MeTrfase_TRMD/TRM10.
    [Graphical view]
    PfamiPF01746. tRNA_m1G_MT. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000386. tRNA_mtase. 1 hit.
    SUPFAMiSSF75217. SSF75217. 1 hit.
    TIGRFAMsiTIGR00088. trmD. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q1IYA3-1 [UniParc]FASTAAdd to Basket

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    MLTFSFLTLF PELLAPFASE ALVGKARARG LLDVQLVNMR DFAENKHLKV    50
    DDTPYGGGAG MVIRVDVVER ALASLPPADE VILLTPAGER FTQQMAEELS 100
    RTTHLAFLCG RYEGFDARVE RLATRELSLG DFVMMGGEAA AACVLEAVAR 150
    LVPGVLGDED SHRADSFSSG LLDYPEYTRP AEWRGEGVPE VLKGGNHAAV 200
    ARWRREQALA RTLARRPDLL PSAGLTPQDS AYLLTLGVTP EQLAAWGAPP 250
    PPLPKRRRGA KPNPN 265
    Length:265
    Mass (Da):28,752
    Last modified:June 13, 2006 - v1
    Checksum:iCAE80C3A93B89808
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000359 Genomic DNA. Translation: ABF45781.1.
    RefSeqiWP_011530615.1. NC_008025.1.
    YP_604950.1. NC_008025.1.

    Genome annotation databases

    EnsemblBacteriaiABF45781; ABF45781; Dgeo_1486.
    GeneIDi4057372.
    KEGGidge:Dgeo_1486.
    PATRICi21624889. VBIDeiGeo41128_2076.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000359 Genomic DNA. Translation: ABF45781.1 .
    RefSeqi WP_011530615.1. NC_008025.1.
    YP_604950.1. NC_008025.1.

    3D structure databases

    ProteinModelPortali Q1IYA3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 319795.Dgeo_1486.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABF45781 ; ABF45781 ; Dgeo_1486 .
    GeneIDi 4057372.
    KEGGi dge:Dgeo_1486.
    PATRICi 21624889. VBIDeiGeo41128_2076.

    Phylogenomic databases

    eggNOGi COG0336.
    HOGENOMi HOG000016242.
    KOi K00554.
    OMAi WRGHEVP.
    OrthoDBi EOG6J48RZ.

    Enzyme and pathway databases

    BioCyci DGEO319795:GHMU-1512-MONOMER.

    Family and domain databases

    Gene3Di 1.10.1270.20. 1 hit.
    3.40.1280.10. 1 hit.
    HAMAPi MF_00605. TrmD.
    InterProi IPR029028. Alpha/beta_knot_MTases.
    IPR002649. tRNA_m1G_MeTrfase_bac.
    IPR023148. tRNA_m1G_MeTrfase_C.
    IPR029026. tRNA_m1G_MTases_N.
    IPR016009. tRNA_MeTrfase_TRMD/TRM10.
    [Graphical view ]
    Pfami PF01746. tRNA_m1G_MT. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000386. tRNA_mtase. 1 hit.
    SUPFAMi SSF75217. SSF75217. 1 hit.
    TIGRFAMsi TIGR00088. trmD. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 11300.

    Entry informationi

    Entry nameiTRMD_DEIGD
    AccessioniPrimary (citable) accession number: Q1IYA3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2006
    Last sequence update: June 13, 2006
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3