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Q1IWZ8

- GSA_DEIGD

UniProt

Q1IWZ8 - GSA_DEIGD

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Protein

Glutamate-1-semialdehyde 2,1-aminomutase

Gene

hemL

Organism
Deinococcus geothermalis (strain DSM 11300)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-4-amino-5-oxopentanoate = 5-aminolevulinate.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi

GO - Molecular functioni

  1. glutamate-1-semialdehyde 2,1-aminomutase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: InterPro
  3. transaminase activity Source: InterPro

GO - Biological processi

  1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Porphyrin biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciDGEO319795:GHMU-1982-MONOMER.
UniPathwayiUPA00251; UER00317.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate-1-semialdehyde 2,1-aminomutaseUniRule annotation (EC:5.4.3.8UniRule annotation)
Short name:
GSAUniRule annotation
Alternative name(s):
Glutamate-1-semialdehyde aminotransferaseUniRule annotation
Short name:
GSA-ATUniRule annotation
Gene namesi
Name:hemLUniRule annotation
Ordered Locus Names:Dgeo_1942
OrganismiDeinococcus geothermalis (strain DSM 11300)
Taxonomic identifieri319795 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciDeinococcalesDeinococcaceaeDeinococcus
ProteomesiUP000002431: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 446446Glutamate-1-semialdehyde 2,1-aminomutasePRO_0000382303Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei278 – 2781N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi319795.Dgeo_1942.

Structurei

3D structure databases

ProteinModelPortaliQ1IWZ8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0001.
HOGENOMiHOG000020210.
KOiK01845.
OrthoDBiEOG6QVRHN.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPiMF_00375. HemL_aminotrans_3.
InterProiIPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11986. PTHR11986. 1 hit.
PfamiPF00202. Aminotran_3. 1 hit.
[Graphical view]
PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR00713. hemL. 1 hit.
PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1IWZ8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTTQIRPFTT QSEALFARAQ AVTPGGVNSP VRAFRSVGGT PRFIREAHGA
60 70 80 90 100
YLTDMDGHRL LDYIGSWGPM ILGHDHPAVR EAVAAALDRG TSFGAPSEGE
110 120 130 140 150
VRLAETVTRL TGVDRVRFVN SGTEATMSAL RLARGFTGRT FIVKFRGNYH
160 170 180 190 200
GHADGLLVEA GSGLMTNAAK TLGQAAPSSA GVPEEYARLT LVCEYNDPAA
210 220 230 240 250
LGALMQERGH DVAAVIFEPV VGNAGVLIPT PEFLAALHRV RDAGALLIAD
260 270 280 290 300
EVMTGFRLSL RGATGLLGLT PDLICWGKII GGGLPVGAYG GRAEVMDFVS
310 320 330 340 350
PQGPVYQAGT LSGNPLAMAA GLATLEVLES DPSIYARLET YTMQLAEGLR
360 370 380 390 400
AAAQAAGVPL SVNQIGSMLT AFHQDAPVGS IRTYADAARS DTGAFAVWFQ
410 420 430 440
RMLAQGIYWA PSQFESIFVS AAHTDSDLNA TLDAAHSAYA QLGGTA
Length:446
Mass (Da):46,789
Last modified:September 1, 2009 - v2
Checksum:iF0DD7B033FDB1C09
GO

Sequence cautioni

The sequence ABF46236.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000359 Genomic DNA. Translation: ABF46236.1. Different initiation.
RefSeqiYP_605405.1. NC_008025.1.

Genome annotation databases

EnsemblBacteriaiABF46236; ABF46236; Dgeo_1942.
GeneIDi4057689.
KEGGidge:Dgeo_1942.
PATRICi21625843. VBIDeiGeo41128_2540.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000359 Genomic DNA. Translation: ABF46236.1 . Different initiation.
RefSeqi YP_605405.1. NC_008025.1.

3D structure databases

ProteinModelPortali Q1IWZ8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 319795.Dgeo_1942.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABF46236 ; ABF46236 ; Dgeo_1942 .
GeneIDi 4057689.
KEGGi dge:Dgeo_1942.
PATRICi 21625843. VBIDeiGeo41128_2540.

Phylogenomic databases

eggNOGi COG0001.
HOGENOMi HOG000020210.
KOi K01845.
OrthoDBi EOG6QVRHN.

Enzyme and pathway databases

UniPathwayi UPA00251 ; UER00317 .
BioCyci DGEO319795:GHMU-1982-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPi MF_00375. HemL_aminotrans_3.
InterProi IPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
PANTHERi PTHR11986. PTHR11986. 1 hit.
Pfami PF00202. Aminotran_3. 1 hit.
[Graphical view ]
PIRSFi PIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR00713. hemL. 1 hit.
PROSITEi PS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 11300.

Entry informationi

Entry nameiGSA_DEIGD
AccessioniPrimary (citable) accession number: Q1IWZ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: September 1, 2009
Last modified: November 26, 2014
This is version 70 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3