Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Argininosuccinate synthase

Gene

argG

Organism
Deinococcus geothermalis (strain DSM 11300)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei42 – 421ATP; via amide nitrogen and carbonyl oxygenUniRule annotation
Binding sitei93 – 931CitrullineUniRule annotation
Binding sitei98 – 981CitrullineUniRule annotation
Binding sitei123 – 1231ATP; via amide nitrogenUniRule annotation
Binding sitei125 – 1251AspartateUniRule annotation
Binding sitei129 – 1291AspartateUniRule annotation
Binding sitei129 – 1291CitrullineUniRule annotation
Binding sitei130 – 1301AspartateUniRule annotation
Binding sitei133 – 1331CitrullineUniRule annotation
Binding sitei182 – 1821CitrullineUniRule annotation
Binding sitei191 – 1911CitrullineUniRule annotation
Binding sitei267 – 2671CitrullineUniRule annotation
Binding sitei279 – 2791CitrullineUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi15 – 239ATPUniRule annotation

GO - Molecular functioni

  1. argininosuccinate synthase activity Source: UniProtKB-HAMAP
  2. ATP binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. arginine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciDGEO319795:GHMU-2114-MONOMER.
UniPathwayiUPA00068; UER00113.

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate synthaseUniRule annotation (EC:6.3.4.5UniRule annotation)
Alternative name(s):
Citrulline--aspartate ligaseUniRule annotation
Gene namesi
Name:argGUniRule annotation
Ordered Locus Names:Dgeo_2067
OrganismiDeinococcus geothermalis (strain DSM 11300)
Taxonomic identifieri319795 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciDeinococcalesDeinococcaceaeDeinococcus
ProteomesiUP000002431 Componenti: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 414414Argininosuccinate synthasePRO_0000263920Add
BLAST

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi319795.Dgeo_2067.

Structurei

3D structure databases

ProteinModelPortaliQ1IWM3.
SMRiQ1IWM3. Positions 11-403.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the argininosuccinate synthase family. Type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0137.
HOGENOMiHOG000230093.
KOiK01940.
OMAiPAREWGM.
OrthoDBiEOG6K9QCV.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPiMF_00005. Arg_succ_synth_type1.
InterProiIPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF00764. Arginosuc_synth. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00032. argG. 1 hit.
PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1IWM3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANVQQGQKD KIVLAYSGGL DTSIILKWLQ TERNYDVVTF TADLGQGDEV
60 70 80 90 100
EEARVKALNT GAVAAYALDL REEFVRDYVF PMFRAAALYE GYYLLGTSIA
110 120 130 140 150
RPLIAKKLVE IAEKEGAVAV SHGATGKGND QVRFEMTAYA LKPDIVTVAP
160 170 180 190 200
WRDWDFQGRA DLETFAREHG IPVPTTKKDP WSTDANLLHI SYEGGILEDP
210 220 230 240 250
WAEPPAHMFK LTVSPEEAPD QPEYVEVEFE NGDPVAIGGE RLSPAALLAK
260 270 280 290 300
ANEIGGRNGV GRIDLVENRF VGMKSRGVYE TPGGTLLYHA RRAVESLTLD
310 320 330 340 350
REVLHQRDAL APKYAELVYN GFWFAPEREA LQVYIDHVAR SVTGTARLKL
360 370 380 390 400
YKGNCTVVGR RAPRSLYDKD LVSFEAGGDY NQHDAGAFIK LNALRMRVQA
410
RVDAKRTQQE VARV
Length:414
Mass (Da):45,975
Last modified:June 12, 2006 - v1
Checksum:i95086A4F026A7201
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000359 Genomic DNA. Translation: ABF46361.1.
RefSeqiWP_011531187.1. NC_008025.1.
YP_605530.1. NC_008025.1.

Genome annotation databases

EnsemblBacteriaiABF46361; ABF46361; Dgeo_2067.
KEGGidge:Dgeo_2067.
PATRICi21626109. VBIDeiGeo41128_2667.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000359 Genomic DNA. Translation: ABF46361.1.
RefSeqiWP_011531187.1. NC_008025.1.
YP_605530.1. NC_008025.1.

3D structure databases

ProteinModelPortaliQ1IWM3.
SMRiQ1IWM3. Positions 11-403.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi319795.Dgeo_2067.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABF46361; ABF46361; Dgeo_2067.
KEGGidge:Dgeo_2067.
PATRICi21626109. VBIDeiGeo41128_2667.

Phylogenomic databases

eggNOGiCOG0137.
HOGENOMiHOG000230093.
KOiK01940.
OMAiPAREWGM.
OrthoDBiEOG6K9QCV.

Enzyme and pathway databases

UniPathwayiUPA00068; UER00113.
BioCyciDGEO319795:GHMU-2114-MONOMER.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPiMF_00005. Arg_succ_synth_type1.
InterProiIPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF00764. Arginosuc_synth. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00032. argG. 1 hit.
PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 11300.

Entry informationi

Entry nameiASSY_DEIGD
AccessioniPrimary (citable) accession number: Q1IWM3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 11, 2006
Last sequence update: June 12, 2006
Last modified: March 31, 2015
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.