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Q1IWK0

- TRMB_DEIGD

UniProt

Q1IWK0 - TRMB_DEIGD

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Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene
trmB, Dgeo_2090
Organism
Deinococcus geothermalis (strain DSM 11300)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA By similarity.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei29 – 291S-adenosyl-L-methionine By similarity
Binding sitei55 – 551S-adenosyl-L-methionine By similarity
Active sitei105 – 1051 By similarity
Binding sitei105 – 1051S-adenosyl-L-methionine By similarity
Binding sitei109 – 1091Substrate By similarity
Binding sitei141 – 1411Substrate By similarity

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciDGEO319795:GHMU-2137-MONOMER.
UniPathwayiUPA00989.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferase (EC:2.1.1.33)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferase
tRNA(m7G46)-methyltransferase
Gene namesi
Name:trmB
Ordered Locus Names:Dgeo_2090
OrganismiDeinococcus geothermalis (strain DSM 11300)
Taxonomic identifieri319795 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciDeinococcalesDeinococcaceaeDeinococcus
ProteomesiUP000002431: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 331331tRNA (guanine-N(7)-)-methyltransferaseUniRule annotationPRO_0000288144Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi319795.Dgeo_2090.

Structurei

3D structure databases

ProteinModelPortaliQ1IWK0.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0220.
HOGENOMiHOG000099573.
KOiK03439.
OMAiTKYALKW.
OrthoDBiEOG6K6VBC.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01057. tRNA_methyltr_TrmB.
InterProiIPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view]
PfamiPF02390. Methyltransf_4. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1IWK0-1 [UniParc]FASTAAdd to Basket

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MIFRLADFHF PDSAARLYPD TPQRPWILEV GFGDGRFWPH YAATFPEAPN    50
YLGVEISGVS LLKAERRLRE AGLSNAVLTK LPATPLIREV VPAGSLDAIV 100
VNFPDPWPKA GHAEHRLLRA PFFRLAASRL KPGGAVLLTT DHDEYFEFAC 150
REAEASGVMR AELTDPPPAA LETKYARKWR ELGLEVQHAR FVPTHHPHVP 200
HGTVARFPDS EDAPAVPHAI LTLPAAFDPG AFHKHTARGG QTREDPVGWT 250
VVLLELYRSL KQDGWVMLAH VVEGELTQEV LIGISARGDG SHLVRLASFG 300
GPIITPGVKA AVGVVTDWLE EQGAAVRHRG Y 331
Length:331
Mass (Da):36,336
Last modified:June 13, 2006 - v1
Checksum:i79FECB6096E34734
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000359 Genomic DNA. Translation: ABF46384.1.
RefSeqiWP_011531210.1. NC_008025.1.
YP_605553.1. NC_008025.1.

Genome annotation databases

EnsemblBacteriaiABF46384; ABF46384; Dgeo_2090.
GeneIDi4058187.
KEGGidge:Dgeo_2090.
PATRICi21626153. VBIDeiGeo41128_2689.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000359 Genomic DNA. Translation: ABF46384.1 .
RefSeqi WP_011531210.1. NC_008025.1.
YP_605553.1. NC_008025.1.

3D structure databases

ProteinModelPortali Q1IWK0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 319795.Dgeo_2090.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABF46384 ; ABF46384 ; Dgeo_2090 .
GeneIDi 4058187.
KEGGi dge:Dgeo_2090.
PATRICi 21626153. VBIDeiGeo41128_2689.

Phylogenomic databases

eggNOGi COG0220.
HOGENOMi HOG000099573.
KOi K03439.
OMAi TKYALKW.
OrthoDBi EOG6K6VBC.

Enzyme and pathway databases

UniPathwayi UPA00989 .
BioCyci DGEO319795:GHMU-2137-MONOMER.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
HAMAPi MF_01057. tRNA_methyltr_TrmB.
InterProi IPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view ]
Pfami PF02390. Methyltransf_4. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 11300.

Entry informationi

Entry nameiTRMB_DEIGD
AccessioniPrimary (citable) accession number: Q1IWK0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: June 13, 2006
Last modified: September 3, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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