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Q1IWK0

- TRMB_DEIGD

UniProt

Q1IWK0 - TRMB_DEIGD

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Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

trmB

Organism
Deinococcus geothermalis (strain DSM 11300)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei29 – 291S-adenosyl-L-methionineUniRule annotation
Binding sitei55 – 551S-adenosyl-L-methionineUniRule annotation
Active sitei105 – 1051By similarity
Binding sitei105 – 1051S-adenosyl-L-methionineUniRule annotation
Binding sitei109 – 1091SubstrateUniRule annotation
Binding sitei141 – 1411SubstrateUniRule annotation

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciDGEO319795:GHMU-2137-MONOMER.
UniPathwayiUPA00989.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
tRNA(m7G46)-methyltransferaseUniRule annotation
Gene namesi
Name:trmBUniRule annotation
Ordered Locus Names:Dgeo_2090
OrganismiDeinococcus geothermalis (strain DSM 11300)
Taxonomic identifieri319795 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciDeinococcalesDeinococcaceaeDeinococcus
ProteomesiUP000002431: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 331331tRNA (guanine-N(7)-)-methyltransferasePRO_0000288144Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi319795.Dgeo_2090.

Structurei

3D structure databases

ProteinModelPortaliQ1IWK0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0220.
HOGENOMiHOG000099573.
KOiK03439.
OMAiTKYALKW.
OrthoDBiEOG6K6VBC.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01057. tRNA_methyltr_TrmB.
InterProiIPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view]
PfamiPF02390. Methyltransf_4. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1IWK0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIFRLADFHF PDSAARLYPD TPQRPWILEV GFGDGRFWPH YAATFPEAPN
60 70 80 90 100
YLGVEISGVS LLKAERRLRE AGLSNAVLTK LPATPLIREV VPAGSLDAIV
110 120 130 140 150
VNFPDPWPKA GHAEHRLLRA PFFRLAASRL KPGGAVLLTT DHDEYFEFAC
160 170 180 190 200
REAEASGVMR AELTDPPPAA LETKYARKWR ELGLEVQHAR FVPTHHPHVP
210 220 230 240 250
HGTVARFPDS EDAPAVPHAI LTLPAAFDPG AFHKHTARGG QTREDPVGWT
260 270 280 290 300
VVLLELYRSL KQDGWVMLAH VVEGELTQEV LIGISARGDG SHLVRLASFG
310 320 330
GPIITPGVKA AVGVVTDWLE EQGAAVRHRG Y
Length:331
Mass (Da):36,336
Last modified:June 13, 2006 - v1
Checksum:i79FECB6096E34734
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000359 Genomic DNA. Translation: ABF46384.1.
RefSeqiWP_011531210.1. NC_008025.1.
YP_605553.1. NC_008025.1.

Genome annotation databases

EnsemblBacteriaiABF46384; ABF46384; Dgeo_2090.
GeneIDi4058187.
KEGGidge:Dgeo_2090.
PATRICi21626153. VBIDeiGeo41128_2689.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000359 Genomic DNA. Translation: ABF46384.1 .
RefSeqi WP_011531210.1. NC_008025.1.
YP_605553.1. NC_008025.1.

3D structure databases

ProteinModelPortali Q1IWK0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 319795.Dgeo_2090.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABF46384 ; ABF46384 ; Dgeo_2090 .
GeneIDi 4058187.
KEGGi dge:Dgeo_2090.
PATRICi 21626153. VBIDeiGeo41128_2689.

Phylogenomic databases

eggNOGi COG0220.
HOGENOMi HOG000099573.
KOi K03439.
OMAi TKYALKW.
OrthoDBi EOG6K6VBC.

Enzyme and pathway databases

UniPathwayi UPA00989 .
BioCyci DGEO319795:GHMU-2137-MONOMER.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
HAMAPi MF_01057. tRNA_methyltr_TrmB.
InterProi IPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view ]
Pfami PF02390. Methyltransf_4. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 11300.

Entry informationi

Entry nameiTRMB_DEIGD
AccessioniPrimary (citable) accession number: Q1IWK0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: June 13, 2006
Last modified: November 26, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3