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Q1IWK0

- TRMB_DEIGD

UniProt

Q1IWK0 - TRMB_DEIGD

Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

trmB

Organism
Deinococcus geothermalis (strain DSM 11300)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 52 (01 Oct 2014)
      Sequence version 1 (13 Jun 2006)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

    Catalytic activityi

    S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei29 – 291S-adenosyl-L-methionineUniRule annotation
    Binding sitei55 – 551S-adenosyl-L-methionineUniRule annotation
    Active sitei105 – 1051By similarity
    Binding sitei105 – 1051S-adenosyl-L-methionineUniRule annotation
    Binding sitei109 – 1091SubstrateUniRule annotation
    Binding sitei141 – 1411SubstrateUniRule annotation

    GO - Molecular functioni

    1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    tRNA processing

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Enzyme and pathway databases

    BioCyciDGEO319795:GHMU-2137-MONOMER.
    UniPathwayiUPA00989.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
    Alternative name(s):
    tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
    tRNA(m7G46)-methyltransferaseUniRule annotation
    Gene namesi
    Name:trmBUniRule annotation
    Ordered Locus Names:Dgeo_2090
    OrganismiDeinococcus geothermalis (strain DSM 11300)
    Taxonomic identifieri319795 [NCBI]
    Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciDeinococcalesDeinococcaceaeDeinococcus
    ProteomesiUP000002431: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 331331tRNA (guanine-N(7)-)-methyltransferasePRO_0000288144Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi319795.Dgeo_2090.

    Structurei

    3D structure databases

    ProteinModelPortaliQ1IWK0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0220.
    HOGENOMiHOG000099573.
    KOiK03439.
    OMAiTKYALKW.
    OrthoDBiEOG6K6VBC.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    HAMAPiMF_01057. tRNA_methyltr_TrmB.
    InterProiIPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view]
    PfamiPF02390. Methyltransf_4. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 1 hit.
    PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q1IWK0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIFRLADFHF PDSAARLYPD TPQRPWILEV GFGDGRFWPH YAATFPEAPN    50
    YLGVEISGVS LLKAERRLRE AGLSNAVLTK LPATPLIREV VPAGSLDAIV 100
    VNFPDPWPKA GHAEHRLLRA PFFRLAASRL KPGGAVLLTT DHDEYFEFAC 150
    REAEASGVMR AELTDPPPAA LETKYARKWR ELGLEVQHAR FVPTHHPHVP 200
    HGTVARFPDS EDAPAVPHAI LTLPAAFDPG AFHKHTARGG QTREDPVGWT 250
    VVLLELYRSL KQDGWVMLAH VVEGELTQEV LIGISARGDG SHLVRLASFG 300
    GPIITPGVKA AVGVVTDWLE EQGAAVRHRG Y 331
    Length:331
    Mass (Da):36,336
    Last modified:June 13, 2006 - v1
    Checksum:i79FECB6096E34734
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000359 Genomic DNA. Translation: ABF46384.1.
    RefSeqiWP_011531210.1. NC_008025.1.
    YP_605553.1. NC_008025.1.

    Genome annotation databases

    EnsemblBacteriaiABF46384; ABF46384; Dgeo_2090.
    GeneIDi4058187.
    KEGGidge:Dgeo_2090.
    PATRICi21626153. VBIDeiGeo41128_2689.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000359 Genomic DNA. Translation: ABF46384.1 .
    RefSeqi WP_011531210.1. NC_008025.1.
    YP_605553.1. NC_008025.1.

    3D structure databases

    ProteinModelPortali Q1IWK0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 319795.Dgeo_2090.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABF46384 ; ABF46384 ; Dgeo_2090 .
    GeneIDi 4058187.
    KEGGi dge:Dgeo_2090.
    PATRICi 21626153. VBIDeiGeo41128_2689.

    Phylogenomic databases

    eggNOGi COG0220.
    HOGENOMi HOG000099573.
    KOi K03439.
    OMAi TKYALKW.
    OrthoDBi EOG6K6VBC.

    Enzyme and pathway databases

    UniPathwayi UPA00989 .
    BioCyci DGEO319795:GHMU-2137-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    HAMAPi MF_01057. tRNA_methyltr_TrmB.
    InterProi IPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view ]
    Pfami PF02390. Methyltransf_4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 1 hit.
    PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 11300.

    Entry informationi

    Entry nameiTRMB_DEIGD
    AccessioniPrimary (citable) accession number: Q1IWK0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 29, 2007
    Last sequence update: June 13, 2006
    Last modified: October 1, 2014
    This is version 52 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3