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Q1IWC9

- MDH_DEIGD

UniProt

Q1IWC9 - MDH_DEIGD

Protein

Malate dehydrogenase

Gene

mdh

Organism
Deinococcus geothermalis (strain DSM 11300)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 1 (13 Jun 2006)
      Previous versions | rss
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    Functioni

    Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotation

    Catalytic activityi

    (S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei98 – 981SubstrateUniRule annotation
    Binding sitei104 – 1041SubstrateUniRule annotation
    Binding sitei111 – 1111NADUniRule annotation
    Binding sitei118 – 1181NADUniRule annotation
    Binding sitei137 – 1371SubstrateUniRule annotation
    Binding sitei168 – 1681SubstrateUniRule annotation
    Active sitei193 – 1931Proton acceptorUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi17 – 237NADUniRule annotation
    Nucleotide bindingi135 – 1373NADUniRule annotation

    GO - Molecular functioni

    1. L-malate dehydrogenase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. cellular carbohydrate metabolic process Source: InterPro
    2. malate metabolic process Source: InterPro
    3. tricarboxylic acid cycle Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Tricarboxylic acid cycle

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciDGEO319795:GHMU-2210-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
    Gene namesi
    Name:mdhUniRule annotation
    Ordered Locus Names:Dgeo_2161
    OrganismiDeinococcus geothermalis (strain DSM 11300)
    Taxonomic identifieri319795 [NCBI]
    Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciDeinococcalesDeinococcaceaeDeinococcus
    ProteomesiUP000002431: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 334334Malate dehydrogenasePRO_0000292372Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi319795.Dgeo_2161.

    Structurei

    3D structure databases

    ProteinModelPortaliQ1IWC9.
    SMRiQ1IWC9. Positions 8-333.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LDH/MDH superfamily. MDH type 2 family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0039.
    HOGENOMiHOG000220953.
    KOiK00024.
    OMAiNCLIASK.
    OrthoDBiEOG6PP9Q2.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    3.90.110.10. 1 hit.
    HAMAPiMF_01517. Malate_dehydrog_2.
    InterProiIPR001557. L-lactate/malate_DH.
    IPR022383. Lactate/malate_DH_C.
    IPR001236. Lactate/malate_DH_N.
    IPR015955. Lactate_DH/Glyco_Ohase_4_C.
    IPR010945. Malate_DH_type2.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR23382. PTHR23382. 1 hit.
    PfamiPF02866. Ldh_1_C. 1 hit.
    PF00056. Ldh_1_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
    SUPFAMiSSF56327. SSF56327. 1 hit.
    TIGRFAMsiTIGR01759. MalateDH-SF1. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q1IWC9-1 [UniParc]FASTAAdd to Basket

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    MTMNQGTKQP VRVAVTGAAG QIGYSLLFRI AAGDMLGKDQ PVILQLLEIT    50
    PALKALAGVV MELRDCAFPL LADIVTSDDP LVAFKDADYA LLVGAMPRKA 100
    GMERGDLLGA NGGIFKPQGE ALNKVASRDV KVLVVGNPAN TNALIAQQNA 150
    PDLDPKQFTA MVRLDHNRAI SQLAEKTGQP VSAIKNITIW GNHSSTQYPD 200
    LSQATVNGQP ALDLVDREWY EKEYIPTVAK RGAAIIEARG ASSAASAASA 250
    AIDHMRDWAL GTPEGEWVSM AVPSDGSYGI PEGLIYGFPV RCRNGQYEIV 300
    QGLEISDFSR QKMDATAKEL EEEREEVRRL GLVK 334
    Length:334
    Mass (Da):35,928
    Last modified:June 13, 2006 - v1
    Checksum:iE011483F19313371
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000359 Genomic DNA. Translation: ABF46455.1.
    RefSeqiWP_011531280.1. NC_008025.1.
    YP_605624.1. NC_008025.1.

    Genome annotation databases

    EnsemblBacteriaiABF46455; ABF46455; Dgeo_2161.
    GeneIDi4058896.
    KEGGidge:Dgeo_2161.
    PATRICi21626301. VBIDeiGeo41128_2761.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000359 Genomic DNA. Translation: ABF46455.1 .
    RefSeqi WP_011531280.1. NC_008025.1.
    YP_605624.1. NC_008025.1.

    3D structure databases

    ProteinModelPortali Q1IWC9.
    SMRi Q1IWC9. Positions 8-333.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 319795.Dgeo_2161.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABF46455 ; ABF46455 ; Dgeo_2161 .
    GeneIDi 4058896.
    KEGGi dge:Dgeo_2161.
    PATRICi 21626301. VBIDeiGeo41128_2761.

    Phylogenomic databases

    eggNOGi COG0039.
    HOGENOMi HOG000220953.
    KOi K00024.
    OMAi NCLIASK.
    OrthoDBi EOG6PP9Q2.

    Enzyme and pathway databases

    BioCyci DGEO319795:GHMU-2210-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    3.90.110.10. 1 hit.
    HAMAPi MF_01517. Malate_dehydrog_2.
    InterProi IPR001557. L-lactate/malate_DH.
    IPR022383. Lactate/malate_DH_C.
    IPR001236. Lactate/malate_DH_N.
    IPR015955. Lactate_DH/Glyco_Ohase_4_C.
    IPR010945. Malate_DH_type2.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR23382. PTHR23382. 1 hit.
    Pfami PF02866. Ldh_1_C. 1 hit.
    PF00056. Ldh_1_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
    SUPFAMi SSF56327. SSF56327. 1 hit.
    TIGRFAMsi TIGR01759. MalateDH-SF1. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 11300.

    Entry informationi

    Entry nameiMDH_DEIGD
    AccessioniPrimary (citable) accession number: Q1IWC9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 26, 2007
    Last sequence update: June 13, 2006
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3