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Q1IWC9

- MDH_DEIGD

UniProt

Q1IWC9 - MDH_DEIGD

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Protein

Malate dehydrogenase

Gene
mdh, Dgeo_2161
Organism
Deinococcus geothermalis (strain DSM 11300)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate By similarity.UniRule annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei98 – 981Substrate By similarity
Binding sitei104 – 1041Substrate By similarity
Binding sitei111 – 1111NAD By similarity
Binding sitei118 – 1181NAD By similarity
Binding sitei137 – 1371Substrate By similarity
Binding sitei168 – 1681Substrate By similarity
Active sitei193 – 1931Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi17 – 237NAD By similarity
Nucleotide bindingi135 – 1373NAD By similarity

GO - Molecular functioni

  1. L-malate dehydrogenase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. malate metabolic process Source: InterPro
  3. tricarboxylic acid cycle Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciDGEO319795:GHMU-2210-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenase (EC:1.1.1.37)
Gene namesi
Name:mdh
Ordered Locus Names:Dgeo_2161
OrganismiDeinococcus geothermalis (strain DSM 11300)
Taxonomic identifieri319795 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciDeinococcalesDeinococcaceaeDeinococcus
ProteomesiUP000002431: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 334334Malate dehydrogenaseUniRule annotationPRO_0000292372Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi319795.Dgeo_2161.

Structurei

3D structure databases

ProteinModelPortaliQ1IWC9.
SMRiQ1IWC9. Positions 8-333.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0039.
HOGENOMiHOG000220953.
KOiK00024.
OMAiNCLIASK.
OrthoDBiEOG6PP9Q2.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPiMF_01517. Malate_dehydrog_2.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR010945. Malate_DH_type2.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23382. PTHR23382. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
SUPFAMiSSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01759. MalateDH-SF1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1IWC9-1 [UniParc]FASTAAdd to Basket

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MTMNQGTKQP VRVAVTGAAG QIGYSLLFRI AAGDMLGKDQ PVILQLLEIT    50
PALKALAGVV MELRDCAFPL LADIVTSDDP LVAFKDADYA LLVGAMPRKA 100
GMERGDLLGA NGGIFKPQGE ALNKVASRDV KVLVVGNPAN TNALIAQQNA 150
PDLDPKQFTA MVRLDHNRAI SQLAEKTGQP VSAIKNITIW GNHSSTQYPD 200
LSQATVNGQP ALDLVDREWY EKEYIPTVAK RGAAIIEARG ASSAASAASA 250
AIDHMRDWAL GTPEGEWVSM AVPSDGSYGI PEGLIYGFPV RCRNGQYEIV 300
QGLEISDFSR QKMDATAKEL EEEREEVRRL GLVK 334
Length:334
Mass (Da):35,928
Last modified:June 13, 2006 - v1
Checksum:iE011483F19313371
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000359 Genomic DNA. Translation: ABF46455.1.
RefSeqiWP_011531280.1. NC_008025.1.
YP_605624.1. NC_008025.1.

Genome annotation databases

EnsemblBacteriaiABF46455; ABF46455; Dgeo_2161.
GeneIDi4058896.
KEGGidge:Dgeo_2161.
PATRICi21626301. VBIDeiGeo41128_2761.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000359 Genomic DNA. Translation: ABF46455.1 .
RefSeqi WP_011531280.1. NC_008025.1.
YP_605624.1. NC_008025.1.

3D structure databases

ProteinModelPortali Q1IWC9.
SMRi Q1IWC9. Positions 8-333.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 319795.Dgeo_2161.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABF46455 ; ABF46455 ; Dgeo_2161 .
GeneIDi 4058896.
KEGGi dge:Dgeo_2161.
PATRICi 21626301. VBIDeiGeo41128_2761.

Phylogenomic databases

eggNOGi COG0039.
HOGENOMi HOG000220953.
KOi K00024.
OMAi NCLIASK.
OrthoDBi EOG6PP9Q2.

Enzyme and pathway databases

BioCyci DGEO319795:GHMU-2210-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPi MF_01517. Malate_dehydrog_2.
InterProi IPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR010945. Malate_DH_type2.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR23382. PTHR23382. 1 hit.
Pfami PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
SUPFAMi SSF56327. SSF56327. 1 hit.
TIGRFAMsi TIGR01759. MalateDH-SF1. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 11300.

Entry informationi

Entry nameiMDH_DEIGD
AccessioniPrimary (citable) accession number: Q1IWC9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: June 13, 2006
Last modified: September 3, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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