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Q1ITW5

- KYNU_KORVE

UniProt

Q1ITW5 - KYNU_KORVE

Protein

Kynureninase

Gene

kynU

Organism
Koribacter versatilis (strain Ellin345)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 57 (01 Oct 2014)
      Sequence version 1 (13 Jun 2006)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.UniRule annotation

    Catalytic activityi

    L-kynurenine + H2O = anthranilate + L-alanine.UniRule annotation
    L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei109 – 1091Pyridoxal phosphate; via amide nitrogenUniRule annotation
    Binding sitei110 – 1101Pyridoxal phosphateUniRule annotation
    Binding sitei222 – 2221Pyridoxal phosphateUniRule annotation
    Binding sitei225 – 2251Pyridoxal phosphateUniRule annotation
    Binding sitei247 – 2471Pyridoxal phosphateUniRule annotation
    Binding sitei278 – 2781Pyridoxal phosphateUniRule annotation
    Binding sitei306 – 3061Pyridoxal phosphateUniRule annotation

    GO - Molecular functioni

    1. kynureninase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' NAD biosynthetic process from tryptophan Source: UniProtKB-HAMAP
    2. anthranilate metabolic process Source: UniProtKB-HAMAP
    3. L-kynurenine catabolic process Source: UniProtKB-UniPathway
    4. quinolinate biosynthetic process Source: UniProtKB-HAMAP
    5. tryptophan catabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Pyridine nucleotide biosynthesis

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciKVER204669:GHL8-687-MONOMER.
    UniPathwayiUPA00253; UER00329.
    UPA00334; UER00455.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    KynureninaseUniRule annotation (EC:3.7.1.3UniRule annotation)
    Alternative name(s):
    L-kynurenine hydrolaseUniRule annotation
    Gene namesi
    Name:kynUUniRule annotation
    Ordered Locus Names:Acid345_0680
    OrganismiKoribacter versatilis (strain Ellin345)
    Taxonomic identifieri204669 [NCBI]
    Taxonomic lineageiBacteriaAcidobacteriaCandidatus Koribacter
    ProteomesiUP000002432: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 424424KynureninasePRO_0000356985Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei248 – 2481N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi204669.Acid345_0680.

    Structurei

    3D structure databases

    ProteinModelPortaliQ1ITW5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni137 – 1404Pyridoxal phosphate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the kynureninase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG3844.
    HOGENOMiHOG000242438.
    KOiK01556.
    OMAiGLMNDIV.
    OrthoDBiEOG6N67XP.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    HAMAPiMF_01970. Kynureninase.
    InterProiIPR000192. Aminotrans_V/Cys_dSase.
    IPR010111. Kynureninase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PANTHERiPTHR14084. PTHR14084. 1 hit.
    PfamiPF00266. Aminotran_5. 1 hit.
    [Graphical view]
    PIRSFiPIRSF038800. KYNU. 1 hit.
    SUPFAMiSSF53383. SSF53383. 1 hit.
    TIGRFAMsiTIGR01814. kynureninase. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q1ITW5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAAAAFDTTE NFAIEMDARD PMSRFRGRFH IPPAPDGSAS VYLVGHSLGL    50
    QPKTVRAYLE QELKDWETLG VEGHFRGKHP WMPYHRLLTE QTARLVCAQP 100
    SEVVVMNSLT VNLHLMMVSF YRPTRERHNI LIEGSAFPSD QYAVQSQIKF 150
    HGFDPASSLL ELCPRVGEAT MRDEDILELI EREGQSIALI LLGGVNYATG 200
    QAFDMAEITK AGHAQGCVVA FDCAHAAGNL ELKLHEWDVD WAAWCSYKYL 250
    NGGPGCIGGC FVHERYARDF ELPRFAGWWG HDQETRFKMG PEFHPMAGAE 300
    GWQLSNPSIL TMAALRASME IFDEAGIGKL RQRSIALTGY LEFLLDQQKS 350
    ARFEIITPRE PERRGAQLSI RVAAGNRSVC DRLVEEGALC DWREPDILRV 400
    APVPLYCSYR DCYRFVQRFV ANLN 424
    Length:424
    Mass (Da):47,776
    Last modified:June 13, 2006 - v1
    Checksum:iDDE23AF052AE8A83
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000360 Genomic DNA. Translation: ABF39685.1.
    RefSeqiYP_589759.1. NC_008009.1.

    Genome annotation databases

    EnsemblBacteriaiABF39685; ABF39685; Acid345_0680.
    GeneIDi4068770.
    KEGGiaba:Acid345_0680.
    PATRICi31978152. VBICanKor57425_0727.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000360 Genomic DNA. Translation: ABF39685.1 .
    RefSeqi YP_589759.1. NC_008009.1.

    3D structure databases

    ProteinModelPortali Q1ITW5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 204669.Acid345_0680.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABF39685 ; ABF39685 ; Acid345_0680 .
    GeneIDi 4068770.
    KEGGi aba:Acid345_0680.
    PATRICi 31978152. VBICanKor57425_0727.

    Phylogenomic databases

    eggNOGi COG3844.
    HOGENOMi HOG000242438.
    KOi K01556.
    OMAi GLMNDIV.
    OrthoDBi EOG6N67XP.

    Enzyme and pathway databases

    UniPathwayi UPA00253 ; UER00329 .
    UPA00334 ; UER00455 .
    BioCyci KVER204669:GHL8-687-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    HAMAPi MF_01970. Kynureninase.
    InterProi IPR000192. Aminotrans_V/Cys_dSase.
    IPR010111. Kynureninase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    PANTHERi PTHR14084. PTHR14084. 1 hit.
    Pfami PF00266. Aminotran_5. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF038800. KYNU. 1 hit.
    SUPFAMi SSF53383. SSF53383. 1 hit.
    TIGRFAMsi TIGR01814. kynureninase. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Ellin345.

    Entry informationi

    Entry nameiKYNU_KORVE
    AccessioniPrimary (citable) accession number: Q1ITW5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 16, 2008
    Last sequence update: June 13, 2006
    Last modified: October 1, 2014
    This is version 57 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3