Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q1ITW5

- KYNU_KORVE

UniProt

Q1ITW5 - KYNU_KORVE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Kynureninase

Gene

kynU

Organism
Koribacter versatilis (strain Ellin345)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.UniRule annotation

Catalytic activityi

L-kynurenine + H2O = anthranilate + L-alanine.UniRule annotation
L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine.UniRule annotation

Cofactori

Pyridoxal phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei109 – 1091Pyridoxal phosphate; via amide nitrogenUniRule annotation
Binding sitei110 – 1101Pyridoxal phosphateUniRule annotation
Binding sitei222 – 2221Pyridoxal phosphateUniRule annotation
Binding sitei225 – 2251Pyridoxal phosphateUniRule annotation
Binding sitei247 – 2471Pyridoxal phosphateUniRule annotation
Binding sitei278 – 2781Pyridoxal phosphateUniRule annotation
Binding sitei306 – 3061Pyridoxal phosphateUniRule annotation

GO - Molecular functioni

  1. kynureninase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' NAD biosynthetic process from tryptophan Source: UniProtKB-HAMAP
  2. anthranilate metabolic process Source: UniProtKB-HAMAP
  3. L-kynurenine catabolic process Source: UniProtKB-UniPathway
  4. quinolinate biosynthetic process Source: UniProtKB-HAMAP
  5. tryptophan catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciKVER204669:GHL8-687-MONOMER.
UniPathwayiUPA00253; UER00329.
UPA00334; UER00455.

Names & Taxonomyi

Protein namesi
Recommended name:
KynureninaseUniRule annotation (EC:3.7.1.3UniRule annotation)
Alternative name(s):
L-kynurenine hydrolaseUniRule annotation
Gene namesi
Name:kynUUniRule annotation
Ordered Locus Names:Acid345_0680
OrganismiKoribacter versatilis (strain Ellin345)
Taxonomic identifieri204669 [NCBI]
Taxonomic lineageiBacteriaAcidobacteriaCandidatus Koribacter
ProteomesiUP000002432: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 424424KynureninasePRO_0000356985Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei248 – 2481N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi204669.Acid345_0680.

Structurei

3D structure databases

ProteinModelPortaliQ1ITW5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni137 – 1404Pyridoxal phosphate bindingUniRule annotation

Sequence similaritiesi

Belongs to the kynureninase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG3844.
HOGENOMiHOG000242438.
KOiK01556.
OMAiGLMNDIV.
OrthoDBiEOG6N67XP.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_01970. Kynureninase.
InterProiIPR000192. Aminotrans_V_dom.
IPR010111. Kynureninase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR14084. PTHR14084. 1 hit.
PfamiPF00266. Aminotran_5. 1 hit.
[Graphical view]
PIRSFiPIRSF038800. KYNU. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01814. kynureninase. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1ITW5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAAAAFDTTE NFAIEMDARD PMSRFRGRFH IPPAPDGSAS VYLVGHSLGL
60 70 80 90 100
QPKTVRAYLE QELKDWETLG VEGHFRGKHP WMPYHRLLTE QTARLVCAQP
110 120 130 140 150
SEVVVMNSLT VNLHLMMVSF YRPTRERHNI LIEGSAFPSD QYAVQSQIKF
160 170 180 190 200
HGFDPASSLL ELCPRVGEAT MRDEDILELI EREGQSIALI LLGGVNYATG
210 220 230 240 250
QAFDMAEITK AGHAQGCVVA FDCAHAAGNL ELKLHEWDVD WAAWCSYKYL
260 270 280 290 300
NGGPGCIGGC FVHERYARDF ELPRFAGWWG HDQETRFKMG PEFHPMAGAE
310 320 330 340 350
GWQLSNPSIL TMAALRASME IFDEAGIGKL RQRSIALTGY LEFLLDQQKS
360 370 380 390 400
ARFEIITPRE PERRGAQLSI RVAAGNRSVC DRLVEEGALC DWREPDILRV
410 420
APVPLYCSYR DCYRFVQRFV ANLN
Length:424
Mass (Da):47,776
Last modified:June 13, 2006 - v1
Checksum:iDDE23AF052AE8A83
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000360 Genomic DNA. Translation: ABF39685.1.
RefSeqiYP_589759.1. NC_008009.1.

Genome annotation databases

EnsemblBacteriaiABF39685; ABF39685; Acid345_0680.
GeneIDi4068770.
KEGGiaba:Acid345_0680.
PATRICi31978152. VBICanKor57425_0727.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000360 Genomic DNA. Translation: ABF39685.1 .
RefSeqi YP_589759.1. NC_008009.1.

3D structure databases

ProteinModelPortali Q1ITW5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 204669.Acid345_0680.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABF39685 ; ABF39685 ; Acid345_0680 .
GeneIDi 4068770.
KEGGi aba:Acid345_0680.
PATRICi 31978152. VBICanKor57425_0727.

Phylogenomic databases

eggNOGi COG3844.
HOGENOMi HOG000242438.
KOi K01556.
OMAi GLMNDIV.
OrthoDBi EOG6N67XP.

Enzyme and pathway databases

UniPathwayi UPA00253 ; UER00329 .
UPA00334 ; UER00455 .
BioCyci KVER204669:GHL8-687-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPi MF_01970. Kynureninase.
InterProi IPR000192. Aminotrans_V_dom.
IPR010111. Kynureninase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
PANTHERi PTHR14084. PTHR14084. 1 hit.
Pfami PF00266. Aminotran_5. 1 hit.
[Graphical view ]
PIRSFi PIRSF038800. KYNU. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR01814. kynureninase. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Ellin345.

Entry informationi

Entry nameiKYNU_KORVE
AccessioniPrimary (citable) accession number: Q1ITW5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: June 13, 2006
Last modified: October 29, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3