Q1ITV2 (DCUP_KORVE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Uroporphyrinogen decarboxylase
Short name=UPD
Short name=URO-D
EC=4.1.1.37

Gene names

Name:	hemE
Ordered Locus Names:	Acid345_0693

Organism

Koribacter versatilis (strain Ellin345)

Taxonomic identifier

204669 [NCBI]

Taxonomic lineage

Bacteria › Acidobacteria › Candidatus Koribacter

Protein attributes

Sequence length	351 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III By similarity. HAMAP MF_00218
Catalytic activity	Uroporphyrinogen III = coproporphyrinogen + 4 CO2. HAMAP MF_00218
Pathway	Porphyrin metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4. HAMAP MF_00218
Subunit structure	Homodimer By similarity. HAMAP MF_00218
Subcellular location	Cytoplasm By similarity HAMAP MF_00218.
Sequence similarities	Belongs to the uroporphyrinogen decarboxylase family.

Ontologies

Keywords
Biological process	Porphyrin biosynthesis
Cellular component	Cytoplasm
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	porphyrin-containing compound biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	uroporphyrinogen decarboxylase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 351	351	Uroporphyrinogen decarboxylase HAMAP MF_00218		PRO_0000325618
Regions
	Region	26 – 30	5	Substrate binding By similarity
Sites
	Binding site	75	1	Substrate By similarity
	Binding site	151	1	Substrate By similarity
	Binding site	206	1	Substrate By similarity
	Binding site	321	1	Substrate By similarity
	Site	75	1	Transition state stabilizer By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q1ITV2 [UniParc]. Last modified June 13, 2006. Version 1. Checksum: ABA24282890C06B1	FASTA	351	39,087
	10 20 30 40 50 60 MAAPNSLFVR ACKRQPVERT PVWFMRQAGR YMSEYRAVRE KYSLVEICKK PDVAAEVTIT 70 80 90 100 110 120 AAEALNVDAA IIFADLLLPL EVMGLPFHFS PGEGPVIEVP IRDAAHITRL RTDRAHDLGY 130 140 150 160 170 180 VAEAVKKVSD HFGSKLPVIG FCGAPFTLAS YMIEGGGSRN YLEVKKLMYN SPHAWDELLG 190 200 210 220 230 240 KLVAVLSEYT ADQVKAGADV IQIFDSWVGC LSVEDYRRYV LPRTTELVKA LQHSTRVPII 250 260 270 280 290 300 YFGTDSATLL PSMRETGAEV IGLDWRVPLD QGWSLLEHSV AIQGNLDPVL LFAEWPELKS 310 320 330 340 350 RAERILKQAD GRPGHIFNLG HGILPHTPVQ NVKDLAKFVH EYSSQLVGPR E

References

[1]

"Three genomes from the phylum Acidobacteria provide insight into the lifestyles of these microorganisms in soils." Ward N.L., Challacombe J.F., Janssen P.H., Henrissat B., Coutinho P.M., Wu M., Xie G., Haft D.H., Sait M., Badger J., Barabote R.D., Bradley B., Brettin T.S., Brinkac L.M., Bruce D., Creasy T., Daugherty S.C., Davidsen T.M. , DeBoy R.T., Detter J.C., Dodson R.J., Durkin A.S., Ganapathy A., Gwinn-Giglio M., Han C.S., Khouri H., Kiss H., Kothari S.P., Madupu R., Nelson K.E., Nelson W.C., Paulsen I., Penn K., Ren Q., Rosovitz M.J., Selengut J.D., Shrivastava S., Sullivan S.A., Tapia R., Thompson L.S., Watkins K.L., Yang Q., Yu C., Zafar N., Zhou L., Kuske C.R. Appl. Environ. Microbiol. 75:2046-2056(2009) [PubMed: 19201974] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Ellin345.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000360 Genomic DNA. Translation: ABF39698.1.
RefSeq	YP_589772.1. NC_008009.1.
3D structure databases
ProteinModelPortal	Q1ITV2.
ModBase	Search...
Protein-protein interaction databases
STRING	Q1ITV2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4071338.
GenomeReviews	Gene locus Acid345_0693 in contig CP000360_GR.
KEGG	aba:Acid345_0693.
NMPDR	fig|204669.6.peg.685.
PATRIC	31978178. VBICanKor57425_0740.
Phylogenomic databases
eggNOG	COG0407.
HOGENOM	HBG628392.
OMA	PRIHFGV.
PhylomeDB	Q1ITV2.
ProtClustDB	CLSK2467472.
Enzyme and pathway databases
BioCyc	ABAC204669:ACID345_0693-MONOMER.
Family and domain databases
HAMAP	MF_00218. URO-D. [Tree]
InterPro	IPR006361. Uroporphyrinogen_deCO2ase_HemE. IPR000257. Uroporphyrinogen_deCOase. [Graphical view]
KO	K01599.
PANTHER	PTHR21091:SF2. HemE. 1 hit.
Pfam	PF01208. URO-D. 1 hit. [Graphical view]
TIGRFAMs	TIGR01464. HemE. 1 hit.
PROSITE	PS00906. UROD_1. 1 hit. PS00907. UROD_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DCUP_KORVE

Accession

Primary (citable) accession number: Q1ITV2

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
Last sequence update:	June 13, 2006
Last modified:	January 25, 2012
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program