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Protein

Branched-chain-amino-acid aminotransferase

Gene

ilvE

Organism
Koribacter versatilis (strain Ellin345)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Acts on leucine, isoleucine and valine.UniRule annotation

Catalytic activityi

L-isoleucine + 2-oxoglutarate = (S)-3-methyl-2-oxopentanoate + L-glutamate.UniRule annotation
L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate.UniRule annotation
L-valine + 2-oxoglutarate = 3-methyl-2-oxobutanoate + L-glutamate.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi: L-isoleucine biosynthesis

This protein is involved in step 4 of the subpathway that synthesizes L-isoleucine from 2-oxobutanoate.UniRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. Acetolactate synthase (Acid345_3108)
  2. Ketol-acid reductoisomerase (NADP(+)) (ilvC)
  3. Dihydroxy-acid dehydratase (ilvD)
  4. Branched-chain-amino-acid aminotransferase (ilvE)
This subpathway is part of the pathway L-isoleucine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-isoleucine from 2-oxobutanoate, the pathway L-isoleucine biosynthesis and in Amino-acid biosynthesis.

Pathwayi: L-leucine biosynthesis

This protein is involved in step 4 of the subpathway that synthesizes L-leucine from 3-methyl-2-oxobutanoate.UniRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. 3-isopropylmalate dehydratase small subunit (leuD), 3-isopropylmalate dehydratase large subunit (leuC)
  3. 3-isopropylmalate dehydrogenase (leuB)
  4. Branched-chain-amino-acid aminotransferase (ilvE)
This subpathway is part of the pathway L-leucine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-leucine from 3-methyl-2-oxobutanoate, the pathway L-leucine biosynthesis and in Amino-acid biosynthesis.

Pathwayi: L-valine biosynthesis

This protein is involved in step 4 of the subpathway that synthesizes L-valine from pyruvate.UniRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. Acetolactate synthase (Acid345_3108)
  2. Ketol-acid reductoisomerase (NADP(+)) (ilvC)
  3. Dihydroxy-acid dehydratase (ilvD)
  4. Branched-chain-amino-acid aminotransferase (ilvE)
This subpathway is part of the pathway L-valine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-valine from pyruvate, the pathway L-valine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferaseUniRule annotationImported, Transferase
Biological processAmino-acid biosynthesis, Branched-chain amino acid biosynthesisUniRule annotation
LigandPyridoxal phosphateUniRule annotation

Enzyme and pathway databases

BioCyciCKOR204669:G1G6H-731-MONOMER
UniPathwayiUPA00047; UER00058
UPA00048; UER00073
UPA00049; UER00062

Names & Taxonomyi

Protein namesi
Recommended name:
Branched-chain-amino-acid aminotransferaseUniRule annotation (EC:2.6.1.42UniRule annotation)
Short name:
BCATUniRule annotation
Gene namesi
Name:ilvEUniRule annotation
Ordered Locus Names:Acid345_0712Imported
OrganismiKoribacter versatilis (strain Ellin345)Imported
Taxonomic identifieri204669 [NCBI]
Taxonomic lineageiBacteriaAcidobacteriaAcidobacterialesAcidobacteriaceaeCandidatus Koribacter
Proteomesi
  • UP000002432 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi204669.Acid345_0712

Structurei

3D structure databases

ProteinModelPortaliQ1ITT3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CM2 Bacteria
COG0115 LUCA
HOGENOMiHOG000276706
KOiK00826
OMAiEVNGHIE
OrthoDBiPOG091H02UL

Family and domain databases

CDDicd01557 BCAT_beta_family, 1 hit
InterProiView protein in InterPro
IPR001544 Aminotrans_IV
IPR018300 Aminotrans_IV_CS
IPR036038 Aminotransferase-like
IPR005785 B_amino_transI
IPR033939 BCAT_family
PfamiView protein in Pfam
PF01063 Aminotran_4, 1 hit
SUPFAMiSSF56752 SSF56752, 1 hit
TIGRFAMsiTIGR01122 ilvE_I, 1 hit
PROSITEiView protein in PROSITE
PS00770 AA_TRANSFER_CLASS_4, 1 hit

Sequencei

Sequence statusi: Complete.

Q1ITT3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAIPVTELIW HNGKMIKWDD AKIHVLSHVV NYGSSLFEGI RCYETKSGPA
60 70 80 90 100
IFRLKEHMQR LLNSSKIYRI DVPFSVDELC NAAVELVGAN KVSPCYIRPI
110 120 130 140 150
VLRGYGELGV NPIGCPTEVY MANYAWGKYL GHGGPDDGVD VCVSSWTRFA
160 170 180 190 200
PNTLPALAKA GANYMNSQLI KMEAILNGYS EGIALDANGY VSEGSGENLF
210 220 230 240 250
IVRDGKIITP PLGNSVLPGI TRDSVIQIAD SLGIEVKEQI IPREMLYVAD
260 270 280 290 300
EVFFTGTAAE VTPIASVDKI QVGTGKAGAI TKTIRKEFFA LIHGEVEDRF
310
GWLTPVKQPV GA
Length:312
Mass (Da):33,975
Last modified:June 13, 2006 - v1
Checksum:iDD15FEA1A0087B6F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000360 Genomic DNA Translation: ABF39717.1
RefSeqiWP_011521519.1, NC_008009.1

Genome annotation databases

EnsemblBacteriaiABF39717; ABF39717; Acid345_0712
KEGGiaba:Acid345_0712

Similar proteinsi

Entry informationi

Entry nameiQ1ITT3_KORVE
AccessioniPrimary (citable) accession number: Q1ITT3
Entry historyiIntegrated into UniProtKB/TrEMBL: June 13, 2006
Last sequence update: June 13, 2006
Last modified: May 23, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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