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Q1ISV1

- NADK_KORVE

UniProt

Q1ISV1 - NADK_KORVE

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Protein
NAD kinase
Gene
nadK, Acid345_1046
Organism
Koribacter versatilis (strain Ellin345)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP By similarity.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

Divalent metal ions By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei68 – 681Proton acceptor By similarity
Binding sitei153 – 1531NAD By similarity
Binding sitei170 – 1701NAD By similarity
Binding sitei172 – 1721NAD By similarity
Binding sitei242 – 2421NAD By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi68 – 692NAD By similarity
Nucleotide bindingi142 – 1432NAD By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. NAD+ kinase activity Source: UniProtKB-HAMAP
  3. metal ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. NAD metabolic process Source: InterPro
  2. NADP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, NAD, NADP, Nucleotide-binding

Enzyme and pathway databases

BioCyciKVER204669:GHL8-1055-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinase (EC:2.7.1.23)
Alternative name(s):
ATP-dependent NAD kinase
Gene namesi
Name:nadK
Ordered Locus Names:Acid345_1046
OrganismiKoribacter versatilis (strain Ellin345)
Taxonomic identifieri204669 [NCBI]
Taxonomic lineageiBacteriaAcidobacteriaCandidatus Koribacter
ProteomesiUP000002432: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 285285NAD kinaseUniRule annotation
PRO_1000079477Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi204669.Acid345_1046.

Structurei

3D structure databases

ProteinModelPortaliQ1ISV1.

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.

Phylogenomic databases

eggNOGiCOG0061.
HOGENOMiHOG000227222.
KOiK00858.
OMAiPRKTKFV.
OrthoDBiEOG6PZXDR.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1ISV1-1 [UniParc]FASTAAdd to Basket

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MKTVAVLSKP SKPELSEIIP PLQEWLGQHG YEVIFDQQSA IYVSGIHGVE    50
RAKIAAMHPE FAIVLGGDGT LLSAARAVAP AGIPILAVNL GSLGFLTEVP 100
LQDMYSTLER VIACNCPLDE RTMLACDLIR DGQVLHSYTS LNDVVVNKSA 150
IARLVGFDVS IDGRFVFNYK ADGVIVATPT GSTAYSLAAG GPVLMPAVGA 200
FQITPVCPHS LTHRPVVVPE TATISIVVRS NGEAAFLTID GQVGQPLKEG 250
DEIVCRKADH AVKLLQMRQS FFKVLREKLK WGERE 285
Length:285
Mass (Da):30,657
Last modified:June 13, 2006 - v1
Checksum:i06CFD04164A811C1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000360 Genomic DNA. Translation: ABF40049.1.
RefSeqiYP_590123.1. NC_008009.1.

Genome annotation databases

EnsemblBacteriaiABF40049; ABF40049; Acid345_1046.
GeneIDi4073133.
KEGGiaba:Acid345_1046.
PATRICi31978936. VBICanKor57425_1116.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000360 Genomic DNA. Translation: ABF40049.1 .
RefSeqi YP_590123.1. NC_008009.1.

3D structure databases

ProteinModelPortali Q1ISV1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 204669.Acid345_1046.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABF40049 ; ABF40049 ; Acid345_1046 .
GeneIDi 4073133.
KEGGi aba:Acid345_1046.
PATRICi 31978936. VBICanKor57425_1116.

Phylogenomic databases

eggNOGi COG0061.
HOGENOMi HOG000227222.
KOi K00858.
OMAi PRKTKFV.
OrthoDBi EOG6PZXDR.

Enzyme and pathway databases

BioCyci KVER204669:GHL8-1055-MONOMER.

Family and domain databases

Gene3Di 2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPi MF_00361. NAD_kinase.
InterProi IPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view ]
PANTHERi PTHR20275. PTHR20275. 1 hit.
Pfami PF01513. NAD_kinase. 1 hit.
[Graphical view ]
SUPFAMi SSF111331. SSF111331. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Ellin345.

Entry informationi

Entry nameiNADK_KORVE
AccessioniPrimary (citable) accession number: Q1ISV1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: June 13, 2006
Last modified: July 9, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3