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Q1ISV1 (NADK_KORVE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NAD kinase

EC=2.7.1.23
Alternative name(s):
ATP-dependent NAD kinase
Gene names
Name:nadK
Ordered Locus Names:Acid345_1046
OrganismKoribacter versatilis (strain Ellin345) [Reference proteome] [HAMAP]
Taxonomic identifier204669 [NCBI]
Taxonomic lineageBacteriaAcidobacteriaCandidatus Koribacter

Protein attributes

Sequence length285 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP By similarity. HAMAP-Rule MF_00361

Catalytic activity

ATP + NAD+ = ADP + NADP+. HAMAP-Rule MF_00361

Cofactor

Divalent metal ions By similarity. HAMAP-Rule MF_00361

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00361.

Sequence similarities

Belongs to the NAD kinase family.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandATP-binding
NAD
NADP
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processNAD metabolic process

Inferred from electronic annotation. Source: InterPro

NADP biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

NAD+ kinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 285285NAD kinase HAMAP-Rule MF_00361
PRO_1000079477

Regions

Nucleotide binding68 – 692NAD By similarity
Nucleotide binding142 – 1432NAD By similarity

Sites

Active site681Proton acceptor By similarity
Binding site1531NAD By similarity
Binding site1701NAD By similarity
Binding site1721NAD By similarity
Binding site2421NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
Q1ISV1 [UniParc].

Last modified June 13, 2006. Version 1.
Checksum: 06CFD04164A811C1

FASTA28530,657
        10         20         30         40         50         60 
MKTVAVLSKP SKPELSEIIP PLQEWLGQHG YEVIFDQQSA IYVSGIHGVE RAKIAAMHPE 

        70         80         90        100        110        120 
FAIVLGGDGT LLSAARAVAP AGIPILAVNL GSLGFLTEVP LQDMYSTLER VIACNCPLDE 

       130        140        150        160        170        180 
RTMLACDLIR DGQVLHSYTS LNDVVVNKSA IARLVGFDVS IDGRFVFNYK ADGVIVATPT 

       190        200        210        220        230        240 
GSTAYSLAAG GPVLMPAVGA FQITPVCPHS LTHRPVVVPE TATISIVVRS NGEAAFLTID 

       250        260        270        280 
GQVGQPLKEG DEIVCRKADH AVKLLQMRQS FFKVLREKLK WGERE 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000360 Genomic DNA. Translation: ABF40049.1.
RefSeqYP_590123.1. NC_008009.1.

3D structure databases

ProteinModelPortalQ1ISV1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING204669.Acid345_1046.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABF40049; ABF40049; Acid345_1046.
GeneID4073133.
KEGGaba:Acid345_1046.
PATRIC31978936. VBICanKor57425_1116.

Phylogenomic databases

eggNOGCOG0061.
HOGENOMHOG000227222.
KOK00858.
OMAPRKTKFV.
OrthoDBEOG6PZXDR.

Enzyme and pathway databases

BioCycKVER204669:GHL8-1055-MONOMER.

Family and domain databases

Gene3D2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPMF_00361. NAD_kinase.
InterProIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERPTHR20275. PTHR20275. 1 hit.
PfamPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMSSF111331. SSF111331. 1 hit.
ProtoNetSearch...

Entry information

Entry nameNADK_KORVE
AccessionPrimary (citable) accession number: Q1ISV1
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: June 13, 2006
Last modified: July 9, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families