Q1ISJ1 (TRPC_KORVE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Indole-3-glycerol phosphate synthase
Short name=IGPS
EC=4.1.1.48

Gene names

Name:	trpC
Ordered Locus Names:	Acid345_1156

Organism

Koribacter versatilis (strain Ellin345)

Taxonomic identifier

204669 [NCBI]

Taxonomic lineage

Bacteria › Acidobacteria › Candidatus Koribacter

Protein attributes

Sequence length	260 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO2 + H2O. HAMAP MF_00134_B
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5. HAMAP MF_00134_B
Sequence similarities	Belongs to the TrpC family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	tryptophan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	indole-3-glycerol-phosphate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 260	260	Indole-3-glycerol phosphate synthase HAMAP MF_00134_B		PRO_1000095844

Sequences

	Sequence		Length	Mass (Da)
	Q1ISJ1 [UniParc]. Last modified June 13, 2006. Version 1. Checksum: A4BD90D9DE2B96D2	FASTA	260	28,763
	10 20 30 40 50 60 MSSTLQAILD DTRRDLAARK SAARTKEFEK RAAEHTPRGF RTALWERAQA GVAVIAELKK 70 80 90 100 110 120 ASPSKGLIRA NFDVIALAKE LEEAGAAALS VLTDVPHFQG SLENLERASQ TVRIPCLRKD 130 140 150 160 170 180 FILDPAQIVE ARAYGADAIL LIVAALTDLD LRNLRDEAKR YGLDVLCEVH DRDELKRAAD 190 200 210 220 230 240 LGFDLIGVNN RNLKTFRVDI ENSLRFAEEF PPNALRVAES GIHSREDIDR LRDAAYSAFL 250 260 IGESLMRADS PSATLRELIG

References

[1]

"Three genomes from the phylum Acidobacteria provide insight into the lifestyles of these microorganisms in soils." Ward N.L., Challacombe J.F., Janssen P.H., Henrissat B., Coutinho P.M., Wu M., Xie G., Haft D.H., Sait M., Badger J., Barabote R.D., Bradley B., Brettin T.S., Brinkac L.M., Bruce D., Creasy T., Daugherty S.C., Davidsen T.M. , DeBoy R.T., Detter J.C., Dodson R.J., Durkin A.S., Ganapathy A., Gwinn-Giglio M., Han C.S., Khouri H., Kiss H., Kothari S.P., Madupu R., Nelson K.E., Nelson W.C., Paulsen I., Penn K., Ren Q., Rosovitz M.J., Selengut J.D., Shrivastava S., Sullivan S.A., Tapia R., Thompson L.S., Watkins K.L., Yang Q., Yu C., Zafar N., Zhou L., Kuske C.R. Appl. Environ. Microbiol. 75:2046-2056(2009) [PubMed: 19201974] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Ellin345.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000360 Genomic DNA. Translation: ABF40159.1.
RefSeq	YP_590233.1. NC_008009.1.
3D structure databases
ProteinModelPortal	Q1ISJ1.
ModBase	Search...
Protein-protein interaction databases
STRING	Q1ISJ1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4069965.
GenomeReviews	Gene locus Acid345_1156 in contig CP000360_GR.
KEGG	aba:Acid345_1156.
NMPDR	fig|204669.6.peg.1145.
PATRIC	31979184. VBICanKor57425_1237.
Phylogenomic databases
eggNOG	COG0134.
HOGENOM	HBG540956.
OMA	FETDINT.
PhylomeDB	Q1ISJ1.
ProtClustDB	CLSK2467510.
Enzyme and pathway databases
BioCyc	ABAC204669:ACID345_1156-MONOMER.
Family and domain databases
HAMAP	MF_00134_B. IGPS_B. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR013798. Indole-3-glycerol_P_synth. IPR001468. Indole-3-GlycerolPSynthase_CS. IPR011060. RibuloseP-bd_barrel. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01609.
Pfam	PF00218. IGPS. 1 hit. [Graphical view]
SUPFAM	SSF51366. RibP_bind_barrel. 1 hit.
PROSITE	PS00614. IGPS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TRPC_KORVE

Accession

Primary (citable) accession number: Q1ISJ1

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	June 13, 2006
Last modified:	January 25, 2012
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program