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Q1IS84 (GLYA_KORVE) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Pyridoxal-phosphate-dependent serine hydroxymethyltransferase
Short name=SHMT
Short name=Serine methylase
EC=2.1.2.1
Gene names
Name:glyA
Ordered Locus Names:Acid345_1264
OrganismKoribacter versatilis (strain Ellin345)
Taxonomic identifier204669 [NCBI]
Taxonomic lineageBacteria › Acidobacteria › Candidatus Koribacter

Protein attributes

Sequence length426 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate serving as the one-carbon carrier By similarity.

Catalytic activity

5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine. HAMAP MF_00051

Cofactor

Pyridoxal phosphate By similarity. HAMAP MF_00051

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP MF_00051

Amino-acid biosynthesis; glycine biosynthesis; glycine from L-serine: step 1/1.

Subunit structure

Homodimer By similarity.

Subcellular location

Cytoplasm By similarity HAMAP MF_00051.

Sequence similarities

Belongs to the SHMT family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 426426Pyridoxal-phosphate-dependent serine hydroxymethyltransferase
PRO_0000369896

Regions

Region126 – 1283Substrate binding By similarity

Sites

Binding site361Pyridoxal phosphate By similarity
Binding site561Pyridoxal phosphate By similarity
Binding site581Substrate By similarity
Binding site651Substrate binding By similarity
Binding site661Pyridoxal phosphate By similarity
Binding site1001Pyridoxal phosphate By similarity
Binding site1221Substrate By similarity
Binding site1771Pyridoxal phosphate By similarity
Binding site2051Pyridoxal phosphate By similarity
Binding site2301Pyridoxal phosphate By similarity
Binding site2371Pyridoxal phosphate By similarity
Binding site2621Pyridoxal phosphate; via amide nitrogen and carbonyl oxygen By similarity
Binding site3621Pyridoxal phosphate By similarity

Amino acid modifications

Modified residue2311N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q1IS84 [UniParc].

Last modified June 13, 2006. Version 1.
Checksum: DDF6BB080F399726

FASTA42646,264
        10         20         30         40         50         60 
MSNRMSQSLN EEDPQIAEAI ANEERRQHEG LELIASENFV SEAVLQAAGS VFTNKYAEGY 

        70         80         90        100        110        120 
PGKRYYGGCE YADVVENLAR DRAKELFGAE HANVQPHSGS SANMEAYGAI LQPGDTILGL 

       130        140        150        160        170        180 
NLAHGGHLTH GHPLNFSGKT YKIVPYGVTK ETETIDYDEL EKLALEHHPK VIVGGGSAYP 

       190        200        210        220        230        240 
RIFDFKRMRE IADKAGALFM VDMAHFAGLV AGGAHPSPVP HAHVVTTTTH KTLRGPRAGM 

       250        260        270        280        290        300 
ILSKQEFAAA IDKVTFPGMQ GGPLVHIIAA KAVCFKEAME PSFKDYANQV VANAKVLAQS 

       310        320        330        340        350        360 
LADQGFRIIS GGTDTHLMLI DVFAAGMLGS EAEKALGEAG ITVNKNAIPF DTNPPMKPSG 

       370        380        390        400        410        420 
VRIGTPALTT RGMKEPEMRQ VGIWIAESLR HRTDPDFLGR VRRQVHELCD AYPLYPERRA 


TRLATV

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000360 Genomic DNA. Translation: ABF40266.1.
RefSeqYP_590340.1. NC_008009.1.

3D structure databases

ProteinModelPortalQ1IS84.
SMRQ1IS84. Positions 9-410.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ1IS84.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4073234.
GenomeReviewsGene locus Acid345_1264 in contig CP000360_GR.
KEGGaba:Acid345_1264.
NMPDRfig|204669.6.peg.1250.
PATRIC31979406. VBICanKor57425_1348.

Phylogenomic databases

eggNOGCOG0112.
HOGENOMHBG301263.
OMAGSSANME.
PhylomeDBQ1IS84.
ProtClustDBPRK00011.

Enzyme and pathway databases

BioCycABAC204669:ACID345_1264-MONOMER.

Family and domain databases

HAMAPMF_00051. SHMT.
[Tree]
InterProIPR015424. PyrdxlP-dep_Trfase_major_dom.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
IPR001085. Ser_HO-MeTrfase.
IPR019798. Ser_HO-MeTrfase_PLP_BS.
[Graphical view]
Gene3DG3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit.
G3DSA:3.90.1150.10. PyrdxlP-dep_Trfase_major_sub2. 1 hit.
KOK00600.
PANTHERPTHR11680. Gly_HO-Metrfase. 1 hit.
PfamPF00464. SHMT. 1 hit.
[Graphical view]
PIRSFPIRSF000412. SHMT. 1 hit.
SUPFAMSSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
PROSITEPS00096. SHMT. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGLYA_KORVE
AccessionPrimary (citable) accession number: Q1IS84
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: June 13, 2006
Last modified: January 25, 2012
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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