ID   Q1IS04_KORVE            Unreviewed;       794 AA.
AC   Q1IS04;
DT   13-JUN-2006, integrated into UniProtKB/TrEMBL.
DT   13-JUN-2006, sequence version 1.
DT   27-MAR-2024, entry version 79.
DE   SubName: Full=Adenylate/guanylate cyclase {ECO:0000313|EMBL:ABF40346.1};
GN   OrderedLocusNames=Acid345_1344 {ECO:0000313|EMBL:ABF40346.1};
OS   Koribacter versatilis (strain Ellin345).
OC   Bacteria; Acidobacteriota; Terriglobia; Terriglobales; Acidobacteriaceae;
OC   Koribacter.
OX   NCBI_TaxID=204669 {ECO:0000313|EMBL:ABF40346.1, ECO:0000313|Proteomes:UP000002432};
RN   [1] {ECO:0000313|EMBL:ABF40346.1, ECO:0000313|Proteomes:UP000002432}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Ellin345 {ECO:0000313|EMBL:ABF40346.1,
RC   ECO:0000313|Proteomes:UP000002432};
RX   PubMed=19201974; DOI=10.1128/AEM.02294-08;
RA   Ward N.L., Challacombe J.F., Janssen P.H., Henrissat B., Coutinho P.M.,
RA   Wu M., Xie G., Haft D.H., Sait M., Badger J., Barabote R.D., Bradley B.,
RA   Brettin T.S., Brinkac L.M., Bruce D., Creasy T., Daugherty S.C.,
RA   Davidsen T.M., DeBoy R.T., Detter J.C., Dodson R.J., Durkin A.S.,
RA   Ganapathy A., Gwinn-Giglio M., Han C.S., Khouri H., Kiss H., Kothari S.P.,
RA   Madupu R., Nelson K.E., Nelson W.C., Paulsen I., Penn K., Ren Q.,
RA   Rosovitz M.J., Selengut J.D., Shrivastava S., Sullivan S.A., Tapia R.,
RA   Thompson L.S., Watkins K.L., Yang Q., Yu C., Zafar N., Zhou L., Kuske C.R.;
RT   "Three genomes from the phylum Acidobacteria provide insight into the
RT   lifestyles of these microorganisms in soils.";
RL   Appl. Environ. Microbiol. 75:2046-2056(2009).
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DR   EMBL; CP000360; ABF40346.1; -; Genomic_DNA.
DR   RefSeq; WP_011522148.1; NC_008009.1.
DR   AlphaFoldDB; Q1IS04; -.
DR   STRING; 204669.Acid345_1344; -.
DR   EnsemblBacteria; ABF40346; ABF40346; Acid345_1344.
DR   KEGG; aba:Acid345_1344; -.
DR   eggNOG; COG2114; Bacteria.
DR   eggNOG; COG4252; Bacteria.
DR   HOGENOM; CLU_000445_85_1_0; -.
DR   OrthoDB; 127505at2; -.
DR   Proteomes; UP000002432; Chromosome.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProt.
DR   GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd07302; CHD; 1.
DR   Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR   InterPro; IPR001054; A/G_cyclase.
DR   InterPro; IPR007890; CHASE2.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   PANTHER; PTHR43081:SF16; ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC; 1.
DR   PANTHER; PTHR43081; ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC-RELATED; 1.
DR   Pfam; PF05226; CHASE2; 1.
DR   Pfam; PF00211; Guanylate_cyc; 1.
DR   SMART; SM01080; CHASE2; 1.
DR   SMART; SM00044; CYCc; 1.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR   PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002432};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        21..47
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        421..438
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        445..467
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        473..494
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          536..668
FT                   /note="Guanylate cyclase"
FT                   /evidence="ECO:0000259|PROSITE:PS50125"
SQ   SEQUENCE   794 AA;  88367 MW;  9643F1B3EE0C6A5A CRC64;
     MMHDVKRIAK VVAVKAMRLF ALVPAWEVDA VIAVVVTAGA LALYLAVARY QERTGFSFIG
     NIELRSLDAR FEMRGSRQTD LDIVIIGVDE KTLRKTGYPI PRRAYASLVN KLASAGCKVI
     GFDLDFPTAE NNSALDVLNR LKGQAGAHTS PEFMSEIDNQ IASSDNDAAF GEAVAKAGNV
     ILGHVFLDSQ QKAQSLSSQE AEDYYKLLWD HPFPQTHPYP DGANFSPADA FMRQKGNTVF
     GVEPNIAKIA ERAKSIGYLD TVFDADGTIR RVPLLIYYKD LDFVPPIEIE MLRYLENISI
     DDSNAFIGQS GVHEIRLGAH AIHPAKDGTA LINYAGPYKT YPHYSLADVL TGEVSPATFH
     NKIVFVGPTA KGMGDMRITP FSTPEAAYMG VEIHANVLDN LLHSENPRRG FLKRGTREET
     VDLVVILLFG IGGGILFAKT PPLRAGIAAL SILGGFAAVA FIVFALFGMW IYVVIPAATV
     VIDYAAISSY RMIFEEREKR KVRKTFERYV APGVIKLIEE NPEKYFRTGG EMRELTVMFS
     DIRGFTEISE GLTPDELVHL LNRYLGDMTG VIFESLGTLD KYIGDAIMAF WGSPVPQSDH
     AYRACETALK MSVALNDLNQ RLTHEGKKTL KIGIGINSGQ MNVGNMGSEF RFAWTVMGDN
     VNLASRLEGQ TKAYKTMRLI TEFTYEEVKD QMVCRQLDVI RVQGKEKPVA IYELMDFVRS
     KDQYEDLLAH FNAARDAYIR QSWSEAITLF EGLLERYPED GPSIVLLDRC KEFRVSPPSR
     DWDGVYTTKK EAVH
//