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Q1IRD8

- CLPP_KORVE

UniProt

Q1IRD8 - CLPP_KORVE

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Protein

ATP-dependent Clp protease proteolytic subunit

Gene
clpP, Acid345_1560
Organism
Koribacter versatilis (strain Ellin345)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins By similarity.UniRule annotation

Catalytic activityi

Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. Alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec; and Leu-Tyr-Leu-|-Tyr-Trp, in which cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp bonds also occurs).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei97 – 971Nucleophile By similarity
Active sitei122 – 1221 By similarity

GO - Molecular functioni

  1. serine-type endopeptidase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Enzyme and pathway databases

BioCyciKVER204669:GHL8-1572-MONOMER.

Protein family/group databases

MEROPSiS14.001.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent Clp protease proteolytic subunit (EC:3.4.21.92)
Alternative name(s):
Endopeptidase Clp
Gene namesi
Name:clpP
Ordered Locus Names:Acid345_1560
OrganismiKoribacter versatilis (strain Ellin345)
Taxonomic identifieri204669 [NCBI]
Taxonomic lineageiBacteriaAcidobacteriaCandidatus Koribacter
ProteomesiUP000002432: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 194194ATP-dependent Clp protease proteolytic subunitUniRule annotationPRO_0000252804Add
BLAST

Interactioni

Subunit structurei

Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes By similarity.

Protein-protein interaction databases

STRINGi204669.Acid345_1560.

Structurei

3D structure databases

ProteinModelPortaliQ1IRD8.
SMRiQ1IRD8. Positions 2-190.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S14 family.

Phylogenomic databases

eggNOGiCOG0740.
HOGENOMiHOG000285833.
KOiK01358.
OMAiTPRREYG.
OrthoDBiEOG6Z3KQ0.

Family and domain databases

Gene3Di3.90.226.10. 1 hit.
HAMAPiMF_00444. ClpP.
InterProiIPR001907. ClpP.
IPR029045. ClpP/crotonase-like_dom.
IPR023562. ClpP/TepA.
IPR018215. ClpP_AS.
[Graphical view]
PANTHERiPTHR10381. PTHR10381. 1 hit.
PfamiPF00574. CLP_protease. 1 hit.
[Graphical view]
PRINTSiPR00127. CLPPROTEASEP.
SUPFAMiSSF52096. SSF52096. 1 hit.
TIGRFAMsiTIGR00493. clpP. 1 hit.
PROSITEiPS00382. CLP_PROTEASE_HIS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1IRD8-1 [UniParc]FASTAAdd to Basket

« Hide

MLVPMVIEQT SRGERAYDIY SRLLRDNIIF LGTPIDDNVA NLIIAQMLFL    50
EAEDPEKDIS LYINSPGGSI TAGMAIYDTM QFIRPDVATI CIGQCASMGA 100
TLLASGAPGK RYALPTSRIL IHQPLMSGLS GQATDIDIHA REILRMREIT 150
NQLLAKHCNQ RLEKVEKDVE RDFIMNAQQA KEYGLVDDII YKHK 194
Length:194
Mass (Da):21,696
Last modified:June 13, 2006 - v1
Checksum:i591CD33ED25CE137
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000360 Genomic DNA. Translation: ABF40562.1.
RefSeqiYP_590636.1. NC_008009.1.

Genome annotation databases

EnsemblBacteriaiABF40562; ABF40562; Acid345_1560.
GeneIDi4068669.
KEGGiaba:Acid345_1560.
PATRICi31980036. VBICanKor57425_1663.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000360 Genomic DNA. Translation: ABF40562.1 .
RefSeqi YP_590636.1. NC_008009.1.

3D structure databases

ProteinModelPortali Q1IRD8.
SMRi Q1IRD8. Positions 2-190.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 204669.Acid345_1560.

Protein family/group databases

MEROPSi S14.001.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABF40562 ; ABF40562 ; Acid345_1560 .
GeneIDi 4068669.
KEGGi aba:Acid345_1560.
PATRICi 31980036. VBICanKor57425_1663.

Phylogenomic databases

eggNOGi COG0740.
HOGENOMi HOG000285833.
KOi K01358.
OMAi TPRREYG.
OrthoDBi EOG6Z3KQ0.

Enzyme and pathway databases

BioCyci KVER204669:GHL8-1572-MONOMER.

Family and domain databases

Gene3Di 3.90.226.10. 1 hit.
HAMAPi MF_00444. ClpP.
InterProi IPR001907. ClpP.
IPR029045. ClpP/crotonase-like_dom.
IPR023562. ClpP/TepA.
IPR018215. ClpP_AS.
[Graphical view ]
PANTHERi PTHR10381. PTHR10381. 1 hit.
Pfami PF00574. CLP_protease. 1 hit.
[Graphical view ]
PRINTSi PR00127. CLPPROTEASEP.
SUPFAMi SSF52096. SSF52096. 1 hit.
TIGRFAMsi TIGR00493. clpP. 1 hit.
PROSITEi PS00382. CLP_PROTEASE_HIS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Ellin345.

Entry informationi

Entry nameiCLPP_KORVE
AccessioniPrimary (citable) accession number: Q1IRD8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: June 13, 2006
Last modified: July 9, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi