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Q1IRD8 (CLPP_KORVE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
ATP-dependent Clp protease proteolytic subunit

EC=3.4.21.92
Alternative name(s):
Endopeptidase Clp
Gene names
Name:clpP
Ordered Locus Names:Acid345_1560
OrganismKoribacter versatilis (strain Ellin345) [Reference proteome] [HAMAP]
Taxonomic identifier204669 [NCBI]
Taxonomic lineageBacteriaAcidobacteriaCandidatus Koribacter

Protein attributes

Sequence length194 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins By similarity. HAMAP-Rule MF_00444

Catalytic activity

Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. Alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec; and Leu-Tyr-Leu-|-Tyr-Trp, in which cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp bonds also occurs). HAMAP-Rule MF_00444

Subunit structure

Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes By similarity.

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00444.

Sequence similarities

Belongs to the peptidase S14 family.

Ontologies

Keywords
   Cellular componentCytoplasm
   Molecular functionHydrolase
Protease
Serine protease
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionserine-type endopeptidase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 194194ATP-dependent Clp protease proteolytic subunit HAMAP-Rule MF_00444
PRO_0000252804

Sites

Active site971Nucleophile By similarity
Active site1221 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q1IRD8 [UniParc].

Last modified June 13, 2006. Version 1.
Checksum: 591CD33ED25CE137

FASTA19421,696
        10         20         30         40         50         60 
MLVPMVIEQT SRGERAYDIY SRLLRDNIIF LGTPIDDNVA NLIIAQMLFL EAEDPEKDIS 

        70         80         90        100        110        120 
LYINSPGGSI TAGMAIYDTM QFIRPDVATI CIGQCASMGA TLLASGAPGK RYALPTSRIL 

       130        140        150        160        170        180 
IHQPLMSGLS GQATDIDIHA REILRMREIT NQLLAKHCNQ RLEKVEKDVE RDFIMNAQQA 

       190 
KEYGLVDDII YKHK 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000360 Genomic DNA. Translation: ABF40562.1.
RefSeqYP_590636.1. NC_008009.1.

3D structure databases

ProteinModelPortalQ1IRD8.
SMRQ1IRD8. Positions 2-190.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING204669.Acid345_1560.

Protein family/group databases

MEROPSS14.001.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABF40562; ABF40562; Acid345_1560.
GeneID4068669.
KEGGaba:Acid345_1560.
PATRIC31980036. VBICanKor57425_1663.

Phylogenomic databases

eggNOGCOG0740.
HOGENOMHOG000285833.
KOK01358.
OMATPRREYG.
OrthoDBEOG6Z3KQ0.

Enzyme and pathway databases

BioCycKVER204669:GHL8-1572-MONOMER.

Family and domain databases

Gene3D3.90.226.10. 1 hit.
HAMAPMF_00444. ClpP.
InterProIPR001907. ClpP.
IPR029045. ClpP/crotonase-like_dom.
IPR023562. ClpP/TepA.
IPR018215. ClpP_AS.
[Graphical view]
PANTHERPTHR10381. PTHR10381. 1 hit.
PfamPF00574. CLP_protease. 1 hit.
[Graphical view]
PRINTSPR00127. CLPPROTEASEP.
SUPFAMSSF52096. SSF52096. 1 hit.
TIGRFAMsTIGR00493. clpP. 1 hit.
PROSITEPS00382. CLP_PROTEASE_HIS. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCLPP_KORVE
AccessionPrimary (citable) accession number: Q1IRD8
Entry history
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: June 13, 2006
Last modified: July 9, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries