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Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Koribacter versatilis (strain Ellin345)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi489 – 4891MagnesiumUniRule annotation
Metal bindingi495 – 4951MagnesiumUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Enzyme and pathway databases

BioCyciKVER204669:GHL8-2013-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
Alternative name(s):
Polynucleotide phosphorylaseUniRule annotation
Short name:
PNPaseUniRule annotation
Gene namesi
Name:pnpUniRule annotation
Ordered Locus Names:Acid345_1995
OrganismiKoribacter versatilis (strain Ellin345)
Taxonomic identifieri204669 [NCBI]
Taxonomic lineageiBacteriaAcidobacteriaAcidobacterialesAcidobacteriaceaeCandidatus Koribacter
ProteomesiUP000002432 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 815815Polyribonucleotide nucleotidyltransferasePRO_0000329478Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi204669.Acid345_1995.

Structurei

3D structure databases

ProteinModelPortaliQ1IQ54.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini556 – 61560KHUniRule annotationAdd
BLAST
Domaini625 – 69268S1 motifUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation
Contains 1 KH domain.UniRule annotation
Contains 1 S1 motif domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG1185.
HOGENOMiHOG000218326.
KOiK00962.
OMAiRFMFHYN.
OrthoDBiEOG6WT8CC.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF13014. KH_3. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1IQ54-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKPEPKVATV EFTGGKSLSF ETGKLAKQAH GSAIVRSGQS VVLATACANA
60 70 80 90 100
DPREGIDFFP LTVDYREYTY AGGRFPGGFI KREGRPSEKE ILTSRQIDRP
110 120 130 140 150
IRPLFPEGFR CETQVIAMVL SADSENDPDV CGINGASAAL AVSDIPFNGP
160 170 180 190 200
IGAVRVGLIE GQNIVNPTYD EMRASKLNIM VVGTAEGIVM IESGAHEATE
210 220 230 240 250
EEVVSAIEFG HGEIKKICAV ISKLAKEVGK TKRTVAPVEL DQPYLDGLRK
260 270 280 290 300
KIGADLADAL NTEKYPKSES YAKVKEIKSK LKEEIPADDD AALKKLGKYY
310 320 330 340 350
ELLREDIFRQ QVTKEKRRPD GRAFDQIRQI WIEVDVLPRT HGSAVFTRGE
360 370 380 390 400
TQALVTTTLG TGDDMQRMEG FEGEAKKRFM LHYNFPPFSV GEVAFLRGAG
410 420 430 440 450
RREIGHGALA ERALSAVLPS EDKWPYAMRV VSDILESNGS SSMASICGGS
460 470 480 490 500
LSLMDAGVPL KAPVAGIAMG LVKEGDDYAI LTDIAGAEDH YGDMDFKVAG
510 520 530 540 550
TTQGITALQM DIKIGGITAQ IMREALEQAR RGRLFILDKM NEVIQSPRTE
560 570 580 590 600
LSEFAPRFYT LQIPTDKIRD LIGPGGKVIR GIVEATGVKI DVEDSGKVNV
610 620 630 640 650
ASSDQEAAKK ALKMIGDITA TAEVGKTYLG TVTRLADFGA FVEILPGTDG
660 670 680 690 700
LLHISEVAEH RIKDVKDELH EGDQVLVKVL AVDGNRIKLS RKAVLKEQRA
710 720 730 740 750
KMATEGGGDG GPAPEVEHSE HGAPGGVTFE GGYEGGDEPE VEEGEPNFNR
760 770 780 790 800
DDAPGSHGAT QPHSGGDRPD RGPRPHGGGG GAGRGGRGRR PGGGGGGGRG
810
GHGGRGGGGG GRGRG
Length:815
Mass (Da):86,885
Last modified:June 13, 2006 - v1
Checksum:iB38FB253DDFCD1D6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000360 Genomic DNA. Translation: ABF40996.1.
RefSeqiWP_011522797.1. NC_008009.1.
YP_591070.1. NC_008009.1.

Genome annotation databases

EnsemblBacteriaiABF40996; ABF40996; Acid345_1995.
KEGGiaba:Acid345_1995.
PATRICi31980970. VBICanKor57425_2124.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000360 Genomic DNA. Translation: ABF40996.1.
RefSeqiWP_011522797.1. NC_008009.1.
YP_591070.1. NC_008009.1.

3D structure databases

ProteinModelPortaliQ1IQ54.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi204669.Acid345_1995.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABF40996; ABF40996; Acid345_1995.
KEGGiaba:Acid345_1995.
PATRICi31980970. VBICanKor57425_2124.

Phylogenomic databases

eggNOGiCOG1185.
HOGENOMiHOG000218326.
KOiK00962.
OMAiRFMFHYN.
OrthoDBiEOG6WT8CC.

Enzyme and pathway databases

BioCyciKVER204669:GHL8-2013-MONOMER.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF13014. KH_3. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Ellin345.

Entry informationi

Entry nameiPNP_KORVE
AccessioniPrimary (citable) accession number: Q1IQ54
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: June 13, 2006
Last modified: May 27, 2015
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.