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Q1IPW7

- UPPP_KORVE

UniProt

Q1IPW7 - UPPP_KORVE

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Protein
Undecaprenyl-diphosphatase
Gene
uppP, Acid345_2082
Organism
Koribacter versatilis (strain Ellin345)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity.UniRule annotation

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functioni

  1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. dephosphorylation Source: InterPro
  2. peptidoglycan biosynthetic process Source: UniProtKB-KW
  3. regulation of cell shape Source: UniProtKB-KW
  4. response to antibiotic Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciKVER204669:GHL8-2102-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphatase (EC:3.6.1.27)
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene namesi
Name:uppP
Ordered Locus Names:Acid345_2082
OrganismiKoribacter versatilis (strain Ellin345)
Taxonomic identifieri204669 [NCBI]
Taxonomic lineageiBacteriaAcidobacteriaCandidatus Koribacter
ProteomesiUP000002432: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei43 – 6321Helical; Reviewed prediction
Add
BLAST
Transmembranei91 – 11121Helical; Reviewed prediction
Add
BLAST
Transmembranei118 – 13821Helical; Reviewed prediction
Add
BLAST
Transmembranei150 – 17021Helical; Reviewed prediction
Add
BLAST
Transmembranei189 – 20921Helical; Reviewed prediction
Add
BLAST
Transmembranei236 – 25621Helical; Reviewed prediction
Add
BLAST
Transmembranei264 – 28421Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 286286Undecaprenyl-diphosphataseUniRule annotation
PRO_0000290674Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi204669.Acid345_2082.

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1968.
HOGENOMiHOG000218356.
KOiK06153.
OMAiWDKIMST.
OrthoDBiEOG6QP13M.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase.
InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1IPW7-1 [UniParc]FASTAAdd to Basket

« Hide

MNAYLLAALL GVVEGLTEFL PVSSTAHLRI CEALLHIDLG DGFWKMFSIV    50
IQLGAILCLP IYFRARISEF FATFPKGKSG NHTALTHPLT LTIIAFLCTA 100
IPAFLFTKII GKHLESVIIM GSALLIGGIV MWIVDVMFAD KGATDDMDKM 150
SVGQAIWIGL CQVLSAVFPG TSRSMSTIAA GQLSGMTRAA ALEFSFFLSI 200
PTMVVATCYD LLKTLRHKDE AGAALGVVHM DAHAWITLAI GFIVSFIVAY 250
FVVAWFMKWV RTRGFVPFAV YRIVVGIAVL AWALKR 286
Length:286
Mass (Da):31,183
Last modified:June 13, 2006 - v1
Checksum:i29948C2DDD70D44B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000360 Genomic DNA. Translation: ABF41083.1.
RefSeqiYP_591157.1. NC_008009.1.

Genome annotation databases

EnsemblBacteriaiABF41083; ABF41083; Acid345_2082.
GeneIDi4069933.
KEGGiaba:Acid345_2082.
PATRICi31981152. VBICanKor57425_2214.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000360 Genomic DNA. Translation: ABF41083.1 .
RefSeqi YP_591157.1. NC_008009.1.

3D structure databases

ModBasei Search...

Protein-protein interaction databases

STRINGi 204669.Acid345_2082.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABF41083 ; ABF41083 ; Acid345_2082 .
GeneIDi 4069933.
KEGGi aba:Acid345_2082.
PATRICi 31981152. VBICanKor57425_2214.

Phylogenomic databases

eggNOGi COG1968.
HOGENOMi HOG000218356.
KOi K06153.
OMAi WDKIMST.
OrthoDBi EOG6QP13M.

Enzyme and pathway databases

BioCyci KVER204669:GHL8-2102-MONOMER.

Family and domain databases

HAMAPi MF_01006. Undec_diphosphatase.
InterProi IPR003824. UppP.
[Graphical view ]
Pfami PF02673. BacA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Ellin345.

Entry informationi

Entry nameiUPPP_KORVE
AccessioniPrimary (citable) accession number: Q1IPW7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: June 13, 2006
Last modified: May 14, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi