Reviewed, UniProtKB/Swiss-Prot Q1IPF0 (AROB_ACIBL)

Names and origin

Protein names

Recommended name:
    3-dehydroquinate synthase
    EC=4.2.3.4

Gene names

Name:	aroB
Ordered Locus Names:	Acid345_2249

Organism

Acidobacteria bacterium (strain Ellin345) [Complete proteome] [HAMAP]

Taxonomic identifier

204669 [NCBI]

Taxonomic lineage

Bacteria › Acidobacteria › Candidatus Koribacter

Protein attributes

Sequence length	366 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate = 3-dehydroquinate + phosphate. HAMAP MF_00110
Cofactor	Divalent metal cations By similarity. NAD By similarity.
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7. HAMAP MF_00110
Subunit structure	Monomer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the dehydroquinate synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Cellular component	Cytoplasm
Ligand	NAD
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3-dehydroquinate synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 366	366	3-dehydroquinate synthase HAMAP MF_00110		PRO_1000094439

Sequences

	Sequence		Length	Mass (Da)
	Q1IPF0-1 [UniParc]. Last modified June 13, 2006. Version 1. Checksum: 6BD0E3B8937B19DA	FASTA	366	40,137
	10 20 30 40 50 60 MNRVPVTTSS RTYDVLIGHE ILRDAGKHIR VVLPKAKRAF VITSAPVRKH WAGIVTDALT 70 80 90 100 110 120 AEGFEVIFLE MEDGERAKNM ASVEDLALKM MAKGADRQSI ICALGGGVVG DVAGFVASVF 130 140 150 160 170 180 MRGIPVIQMP TTFLAQVDSS IGGKTGVNLK AGKNLVGTFY QPWLVLADPG VFSTLPEREF 190 200 210 220 230 240 RSGLYESLKC GVIRRPDLFD RMERDRQRIV ERDPGLIEWL ITESVRVKAD VVGADEHESG 250 260 270 280 290 300 ERRILNFGHT IGHALEAETA YKYFLHGEAV AWGMIAVTMI AAGLQRTDSA TAQRIISLCL 310 320 330 340 350 360 AYAPLPKIEV NAKKTANRVK GDKKTVHGVT HFILPREIGK VEVAIDVTDR AVVQAIEELK YLSFVG

References

[1]

"Three genomes from the phylum Acidobacteria provide insight into the lifestyles of these microorganisms in soils." Ward N.L., Challacombe J.F., Janssen P.H., Henrissat B., Coutinho P.M., Wu M., Xie G., Haft D.H., Sait M., Badger J., Barabote R.D., Bradley B., Brettin T.S., Brinkac L.M., Bruce D., Creasy T., Daugherty S.C., Davidsen T.M. , DeBoy R.T., Detter J.C., Dodson R.J., Durkin A.S., Ganapathy A., Gwinn-Giglio M., Han C.S., Khouri H., Kiss H., Kothari S.P., Madupu R., Nelson K.E., Nelson W.C., Paulsen I., Penn K., Ren Q., Rosovitz M.J., Selengut J.D., Shrivastava S., Sullivan S.A., Tapia R., Thompson L.S., Watkins K.L., Yang Q., Yu C., Zafar N., Zhou L., Kuske C.R. Appl. Environ. Microbiol. 75:2046-2056(2009) [PubMed: 19201974] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000360 Genomic DNA. Translation: ABF41250.1.
RefSeq	YP_591324.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q1IPF0.
Genome annotation databases
GeneID	4072994.
GenomeReviews	Gene locus Acid345_2249 in contig CP000360_GR.
KEGG	aba:Acid345_2249.
NMPDR	fig|204669.6.peg.2232.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q1IPF0.
OMA	LGEVIKY.
Family and domain databases
HAMAP	MF_00110. [Tree]
InterPro	IPR016303. DHQ_synth. IPR002658. DHQ_synth_AroB. IPR016037. DHQ_synth_AroB_sub. [Graphical view]
PANTHER	PTHR21090:SF1. DHQ_synth_AroB. 1 hit.
Pfam	PF01761. DHQ_synthase. 1 hit. [Graphical view]
PIRSF	PIRSF001455. DHQ_synth. 1 hit.
TIGRFAMs	TIGR01357. aroB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AROB_ACIBL

Accession

Primary (citable) accession number: Q1IPF0

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	June 13, 2006
Last modified:	November 3, 2009
This is version 24 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)