Q1INU1 (Q1INU1_KORVE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Probable glycine dehydrogenase [decarboxylating] subunit 2 HAMAP-Rule MF_00713
EC=1.4.4.2 HAMAP-Rule MF_00713

Alternative name(s):
Glycine cleavage system P-protein subunit 2 HAMAP-Rule MF_00713
Glycine decarboxylase subunit 2 HAMAP-Rule MF_00713

Gene names

Name:	gcvPB HAMAP-Rule MF_00713
Ordered Locus Names:	Acid345_2458

Organism

Koribacter versatilis (strain Ellin345) [Reference proteome] [HAMAP]

Taxonomic identifier

204669 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Fibrobacteres/Acidobacteria group › Acidobacteria › unclassified Acidobacteria › Candidatus Koribacter › Candidatus Koribacter versatilis

Protein attributes

Sequence length	505 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00713 SAAS SAAS020581
Catalytic activity	Glycine + H-protein-lipoyllysine = H-protein-S-aminomethyldihydrolipoyllysine + CO2. HAMAP-Rule MF_00713 SAAS SAAS020581
Cofactor	Pyridoxal phosphate By similarity. HAMAP-Rule MF_00713 SAAS SAAS020581
Subunit structure	The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity. HAMAP-Rule MF_00713 SAAS SAAS020581
Sequence similarities	Belongs to the GcvP family. C-terminal subunit subfamily. HAMAP-Rule MF_00713

Ontologies

Keywords
Ligand	Pyridoxal phosphate HAMAP-Rule MF_00713 SAAS SAAS020581
Molecular function	Oxidoreductase HAMAP-Rule MF_00713 SAAS SAAS020581 EMBL ABF41459.1
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	glycine decarboxylation via glycine cleavage system Inferred from electronic annotation. Source: HAMAP
Molecular_function	glycine dehydrogenase (decarboxylating) activity Inferred from electronic annotation. Source: EC pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Amino acid modifications
	Modified residue	285	1	N6-(pyridoxal phosphate)lysine By similarity HAMAP-Rule MF_00713

Sequences

	Sequence		Length	Mass (Da)
	Q1INU1 [UniParc]. Last modified June 13, 2006. Version 1. Checksum: C7B29DA0B169C9B7	FASTA	505	55,426
	10 20 30 40 50 60 MSNLNDKITK VATHVSQNED LIFEKSSPGK KAYRLPPLDV PDVDERALLG AEYVREDLGN 70 80 90 100 110 120 MPEVSEIEII RHFTRMSTWN YAVDYGMYPL GSCTMKYNAR INEVVARLDG IAGAHPYQPE 130 140 150 160 170 180 KLSQGNLRIM KMLADQLVEI TGMDSITLQP AAGAHGEMTG ILLIRAYLES QGNPRKKILI 190 200 210 220 230 240 PDSAHGTNPA TAAICGYQVE NLKSNSAGLT DIPSLVAQMN EDVAALMLTN PNTLGVFEQE 250 260 270 280 290 300 IHKIADILHE KGGQLYMDGA NMNALVGKTR PGDFGVDVMH LNLHKTFSTP HGGGGPGSGP 310 320 330 340 350 360 VAIKKHLEPF LPKPVVVANS DGTLRLDYDR PKSIGRVRMY FGNFGMHVRA LAYIMANGPD 370 380 390 400 410 420 GLRLTTEDAV LNANYIRKKL AGIYDLPYST PSMHEVVFSD RNQARKGIKT GDIAKRLIDY 430 440 450 460 470 480 GFHPYTTSFP LIVPGALMIE PTESESKEEL DQFIEAMKAV AEEAENNPEI IAGAPYNTRV 490 500 SRMDETAAAR KPILRWKPKA KSAAE

References

[1]

"Three genomes from the phylum Acidobacteria provide insight into the lifestyles of these microorganisms in soils." Ward N.L., Challacombe J.F., Janssen P.H., Henrissat B., Coutinho P.M., Wu M., Xie G., Haft D.H., Sait M., Badger J., Barabote R.D., Bradley B., Brettin T.S., Brinkac L.M., Bruce D., Creasy T., Daugherty S.C., Davidsen T.M. , DeBoy R.T., Detter J.C., Dodson R.J., Durkin A.S., Ganapathy A., Gwinn-Giglio M., Han C.S., Khouri H., Kiss H., Kothari S.P., Madupu R., Nelson K.E., Nelson W.C., Paulsen I., Penn K., Ren Q., Rosovitz M.J., Selengut J.D., Shrivastava S., Sullivan S.A., Tapia R., Thompson L.S., Watkins K.L., Yang Q., Yu C., Zafar N., Zhou L., Kuske C.R. Appl. Environ. Microbiol. 75:2046-2056(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Ellin345.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000360 Genomic DNA. Translation: ABF41459.1.
RefSeq	YP_591533.1. NC_008009.1.
3D structure databases
ProteinModelPortal	Q1INU1.
SMR	Q1INU1. Positions 19-497.
ModBase	Search...
Protein-protein interaction databases
STRING	204669.Acid345_2458.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABF41459; ABF41459; Acid345_2458.
GeneID	4072082.
KEGG	aba:Acid345_2458.
PATRIC	31981962. VBICanKor57425_2617.
Phylogenomic databases
eggNOG	COG1003.
HOGENOM	HOG000239368.
KO	K00283.
OMA	RHYTRLS.
ProtClustDB	PRK04366.
Enzyme and pathway databases
BioCyc	KVER204669:GHL8-2511-MONOMER.
Family and domain databases
Gene3D	3.40.640.10. 1 hit.
HAMAP	MF_00713. GcvPB.
InterPro	IPR020580. GDC-P_N. IPR020581. GDC_P. IPR023012. GDC_P_su2. IPR015424. PyrdxlP-dep_Trfase. IPR015421. PyrdxlP-dep_Trfase_major_sub1. [Graphical view]
PANTHER	PTHR11773. PTHR11773. 1 hit.
Pfam	PF02347. GDC-P. 1 hit. [Graphical view]
SUPFAM	SSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
ProtoNet	Search...

Entry information

Entry name

Q1INU1_KORVE

Accession

Primary (citable) accession number: Q1INU1

Entry history

Integrated into UniProtKB/TrEMBL:	June 13, 2006
Last sequence update:	June 13, 2006
Last modified:	May 1, 2013
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)