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Q1INU0 (GCSPA_KORVE) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein subunit 1
Glycine decarboxylase subunit 1
Glycine dehydrogenase (aminomethyl-transferring) subunit 1
Gene names
Name:gcvPA
Ordered Locus Names:Acid345_2459
OrganismKoribacter versatilis (strain Ellin345) [Reference proteome] [HAMAP]
Taxonomic identifier204669 [NCBI]
Taxonomic lineageBacteriaAcidobacteriaCandidatus Koribacter

Protein attributes

Sequence length443 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00712

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00712

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity.

Sequence similarities

Belongs to the GcvP family. N-terminal subunit subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 443443Probable glycine dehydrogenase (decarboxylating) subunit 1 HAMAP-Rule MF_00712
PRO_1000045633

Sequences

Sequence LengthMass (Da)Tools
Q1INU0 [UniParc].

Last modified June 13, 2006. Version 1.
Checksum: 3C1DD66EFC1D5F88

FASTA44348,428
        10         20         30         40         50         60 
MRYLPKSQSD RDQMLRELGC ATIDDLFAPI PAEYRLTRDL AIPRQYGESE ILDFFKQRAS 

        70         80         90        100        110        120 
ENANGYSIFI GAGAYNHYRP VVIDSLISRG EWFTAYTPYQ PEISQGTLQA IFEFQSMICE 

       130        140        150        160        170        180 
LTGMEVANAS MYDGSTGAAE AIMMAVRLTG RHSAIIANTV HPEYREVIAT YAQHQGLPIS 

       190        200        210        220        230        240 
HVGYNAETGR VDIKALEAAI TDQTAAVLIQ SPNFFGTIED VAAIADLVHK KGALLVVSIS 

       250        260        270        280        290        300 
EALSLGLIKP PSEADIISME SQSFGVPLGY GGPYVGVIAT KEKFVRQIPG RLCGQTVDRN 

       310        320        330        340        350        360 
GKRGFVLTLS TREQHIRREK ATSNICTNQA LIALIASIFM TVYGKQGLRE LAKQNLAKTA 

       370        380        390        400        410        420 
YAVSAFEKAG AKVLFKNSPF FNEFVVQTKS DSRELNDKLI SDKIIGGFPL KKFYPELGNS 

       430        440 
AVWCVTELNA KAAIDAAAKG VAQ 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000360 Genomic DNA. Translation: ABF41460.1.
RefSeqYP_591534.1. NC_008009.1.

3D structure databases

ProteinModelPortalQ1INU0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING204669.Acid345_2459.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABF41460; ABF41460; Acid345_2459.
GeneID4072083.
KEGGaba:Acid345_2459.
PATRIC31981964. VBICanKor57425_2618.

Phylogenomic databases

eggNOGCOG0403.
HOGENOMHOG000132025.
KOK00282.
OMASMYDGST.
OrthoDBEOG6XWV3B.
ProtClustDBPRK00451.

Enzyme and pathway databases

BioCycKVER204669:GHL8-2481-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
HAMAPMF_00712. GcvPA.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023010. GDC_P_su1.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 1 hit.
[Graphical view]
PIRSFPIRSF006815. GcvPA. 1 hit.
SUPFAMSSF53383. SSF53383. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSPA_KORVE
AccessionPrimary (citable) accession number: Q1INU0
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: June 13, 2006
Last modified: February 19, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families