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Q1INU0

- GCSPA_KORVE

UniProt

Q1INU0 - GCSPA_KORVE

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Protein
Probable glycine dehydrogenase (decarboxylating) subunit 1
Gene
gcvPA, Acid345_2459
Organism
Koribacter versatilis (strain Ellin345)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine catabolic process Source: InterPro
  2. nucleoside metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Enzyme and pathway databases

BioCyciKVER204669:GHL8-2481-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1 (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein subunit 1
Glycine decarboxylase subunit 1
Glycine dehydrogenase (aminomethyl-transferring) subunit 1
Gene namesi
Name:gcvPA
Ordered Locus Names:Acid345_2459
OrganismiKoribacter versatilis (strain Ellin345)
Taxonomic identifieri204669 [NCBI]
Taxonomic lineageiBacteriaAcidobacteriaCandidatus Koribacter
ProteomesiUP000002432: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 443443Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotation
PRO_1000045633Add
BLAST

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity.

Protein-protein interaction databases

STRINGi204669.Acid345_2459.

Structurei

3D structure databases

ProteinModelPortaliQ1INU0.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0403.
HOGENOMiHOG000132025.
KOiK00282.
OMAiGLEVANC.
OrthoDBiEOG6XWV3B.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00712. GcvPA.
InterProiIPR023010. GcvPA.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 1 hit.
[Graphical view]
PIRSFiPIRSF006815. GcvPA. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1INU0-1 [UniParc]FASTAAdd to Basket

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MRYLPKSQSD RDQMLRELGC ATIDDLFAPI PAEYRLTRDL AIPRQYGESE    50
ILDFFKQRAS ENANGYSIFI GAGAYNHYRP VVIDSLISRG EWFTAYTPYQ 100
PEISQGTLQA IFEFQSMICE LTGMEVANAS MYDGSTGAAE AIMMAVRLTG 150
RHSAIIANTV HPEYREVIAT YAQHQGLPIS HVGYNAETGR VDIKALEAAI 200
TDQTAAVLIQ SPNFFGTIED VAAIADLVHK KGALLVVSIS EALSLGLIKP 250
PSEADIISME SQSFGVPLGY GGPYVGVIAT KEKFVRQIPG RLCGQTVDRN 300
GKRGFVLTLS TREQHIRREK ATSNICTNQA LIALIASIFM TVYGKQGLRE 350
LAKQNLAKTA YAVSAFEKAG AKVLFKNSPF FNEFVVQTKS DSRELNDKLI 400
SDKIIGGFPL KKFYPELGNS AVWCVTELNA KAAIDAAAKG VAQ 443
Length:443
Mass (Da):48,428
Last modified:June 13, 2006 - v1
Checksum:i3C1DD66EFC1D5F88
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000360 Genomic DNA. Translation: ABF41460.1.
RefSeqiYP_591534.1. NC_008009.1.

Genome annotation databases

EnsemblBacteriaiABF41460; ABF41460; Acid345_2459.
GeneIDi4072083.
KEGGiaba:Acid345_2459.
PATRICi31981964. VBICanKor57425_2618.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000360 Genomic DNA. Translation: ABF41460.1 .
RefSeqi YP_591534.1. NC_008009.1.

3D structure databases

ProteinModelPortali Q1INU0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 204669.Acid345_2459.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABF41460 ; ABF41460 ; Acid345_2459 .
GeneIDi 4072083.
KEGGi aba:Acid345_2459.
PATRICi 31981964. VBICanKor57425_2618.

Phylogenomic databases

eggNOGi COG0403.
HOGENOMi HOG000132025.
KOi K00282.
OMAi GLEVANC.
OrthoDBi EOG6XWV3B.

Enzyme and pathway databases

BioCyci KVER204669:GHL8-2481-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
HAMAPi MF_00712. GcvPA.
InterProi IPR023010. GcvPA.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 1 hit.
[Graphical view ]
PIRSFi PIRSF006815. GcvPA. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Ellin345.

Entry informationi

Entry nameiGCSPA_KORVE
AccessioniPrimary (citable) accession number: Q1INU0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: June 13, 2006
Last modified: September 3, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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