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Q1INU0

- GCSPA_KORVE

UniProt

Q1INU0 - GCSPA_KORVE

Protein

Probable glycine dehydrogenase (decarboxylating) subunit 1

Gene

gcvPA

Organism
Koribacter versatilis (strain Ellin345)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 56 (01 Oct 2014)
      Sequence version 1 (13 Jun 2006)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine catabolic process Source: InterPro
    2. nucleoside metabolic process Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Enzyme and pathway databases

    BioCyciKVER204669:GHL8-2481-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-protein subunit 1UniRule annotation
    Glycine decarboxylase subunit 1UniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring) subunit 1UniRule annotation
    Gene namesi
    Name:gcvPAUniRule annotation
    Ordered Locus Names:Acid345_2459
    OrganismiKoribacter versatilis (strain Ellin345)
    Taxonomic identifieri204669 [NCBI]
    Taxonomic lineageiBacteriaAcidobacteriaCandidatus Koribacter
    ProteomesiUP000002432: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 443443Probable glycine dehydrogenase (decarboxylating) subunit 1PRO_1000045633Add
    BLAST

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

    Protein-protein interaction databases

    STRINGi204669.Acid345_2459.

    Structurei

    3D structure databases

    ProteinModelPortaliQ1INU0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family. N-terminal subunit subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0403.
    HOGENOMiHOG000132025.
    KOiK00282.
    OMAiGLEVANC.
    OrthoDBiEOG6XWV3B.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    HAMAPiMF_00712. GcvPA.
    InterProiIPR023010. GcvPA.
    IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 1 hit.
    [Graphical view]
    PIRSFiPIRSF006815. GcvPA. 1 hit.
    SUPFAMiSSF53383. SSF53383. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q1INU0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRYLPKSQSD RDQMLRELGC ATIDDLFAPI PAEYRLTRDL AIPRQYGESE    50
    ILDFFKQRAS ENANGYSIFI GAGAYNHYRP VVIDSLISRG EWFTAYTPYQ 100
    PEISQGTLQA IFEFQSMICE LTGMEVANAS MYDGSTGAAE AIMMAVRLTG 150
    RHSAIIANTV HPEYREVIAT YAQHQGLPIS HVGYNAETGR VDIKALEAAI 200
    TDQTAAVLIQ SPNFFGTIED VAAIADLVHK KGALLVVSIS EALSLGLIKP 250
    PSEADIISME SQSFGVPLGY GGPYVGVIAT KEKFVRQIPG RLCGQTVDRN 300
    GKRGFVLTLS TREQHIRREK ATSNICTNQA LIALIASIFM TVYGKQGLRE 350
    LAKQNLAKTA YAVSAFEKAG AKVLFKNSPF FNEFVVQTKS DSRELNDKLI 400
    SDKIIGGFPL KKFYPELGNS AVWCVTELNA KAAIDAAAKG VAQ 443
    Length:443
    Mass (Da):48,428
    Last modified:June 13, 2006 - v1
    Checksum:i3C1DD66EFC1D5F88
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000360 Genomic DNA. Translation: ABF41460.1.
    RefSeqiYP_591534.1. NC_008009.1.

    Genome annotation databases

    EnsemblBacteriaiABF41460; ABF41460; Acid345_2459.
    GeneIDi4072083.
    KEGGiaba:Acid345_2459.
    PATRICi31981964. VBICanKor57425_2618.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000360 Genomic DNA. Translation: ABF41460.1 .
    RefSeqi YP_591534.1. NC_008009.1.

    3D structure databases

    ProteinModelPortali Q1INU0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 204669.Acid345_2459.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABF41460 ; ABF41460 ; Acid345_2459 .
    GeneIDi 4072083.
    KEGGi aba:Acid345_2459.
    PATRICi 31981964. VBICanKor57425_2618.

    Phylogenomic databases

    eggNOGi COG0403.
    HOGENOMi HOG000132025.
    KOi K00282.
    OMAi GLEVANC.
    OrthoDBi EOG6XWV3B.

    Enzyme and pathway databases

    BioCyci KVER204669:GHL8-2481-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    HAMAPi MF_00712. GcvPA.
    InterProi IPR023010. GcvPA.
    IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF006815. GcvPA. 1 hit.
    SUPFAMi SSF53383. SSF53383. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Ellin345.

    Entry informationi

    Entry nameiGCSPA_KORVE
    AccessioniPrimary (citable) accession number: Q1INU0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: June 13, 2006
    Last modified: October 1, 2014
    This is version 56 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3