Q1INT8 (GCST_KORVE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aminomethyltransferase
EC=2.1.2.10

Alternative name(s):
Glycine cleavage system T protein

Gene names

Name:	gcvT
Ordered Locus Names:	Acid345_2461

Organism

Koribacter versatilis (strain Ellin345)

Taxonomic identifier

204669 [NCBI]

Taxonomic lineage

Bacteria › Acidobacteria › Candidatus Koribacter

Protein attributes

Sequence length	380 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The glycine cleavage system catalyzes the degradation of glycine By similarity. HAMAP MF_00259
Catalytic activity	[Protein]-S(8)-aminomethyldihydrolipoyllysine + tetrahydrofolate = [protein]-dihydrolipoyllysine + 5,10-methylenetetrahydrofolate + NH3. HAMAP MF_00259
Subunit structure	The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.
Sequence similarities	Belongs to the GcvT family.

Ontologies

Keywords
Molecular function	Aminotransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	glycine catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	aminomethyltransferase activity Inferred from electronic annotation. Source: EC transaminase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 380	380	Aminomethyltransferase HAMAP MF_00259		PRO_1000125627

Sequences

	Sequence		Length	Mass (Da)
	Q1INT8 [UniParc]. Last modified June 13, 2006. Version 1. Checksum: 87513DF46CE93217	FASTA	380	42,105
	10 20 30 40 50 60 MNPPVEANIR KTALNATHRQ SGAKMVDYSG WDMPVEYPSV GGLMKEHLAV RAGVGLFDVS 70 80 90 100 110 120 HMGDIRVHGP EALKAVQYLT MNDASKLNTG QAQYSAMLYP NGTFVDDVIV HKFADDDYLL 130 140 150 160 170 180 VINAGTREKD VNWVKDNTRQ FKVTVEDLSD QFTQIAIQGP KGVDTLQKLT DVDLSKVKFY 190 200 210 220 230 240 WFTRGTVAGL KNVLIARTGY TAEDGFEIYI PSDAATSDRV WNELLQAGKE FGVVPAGLGS 250 260 270 280 290 300 RNTLRLEGKL PLYGHEISDE INVWEAGLDR FLKMDKGDFI GRAALEKAKN DGVKRALVGL 310 320 330 340 350 360 ETIERGIPRD GYKVLDLEGK EIGYVTSGSY MPFLKRNLAL AYVPVEQSAL DNIVAVEIRN 370 380 QPVKAKVVPS QFYKRPKKSS

References

[1]

"Three genomes from the phylum Acidobacteria provide insight into the lifestyles of these microorganisms in soils." Ward N.L., Challacombe J.F., Janssen P.H., Henrissat B., Coutinho P.M., Wu M., Xie G., Haft D.H., Sait M., Badger J., Barabote R.D., Bradley B., Brettin T.S., Brinkac L.M., Bruce D., Creasy T., Daugherty S.C., Davidsen T.M. , DeBoy R.T., Detter J.C., Dodson R.J., Durkin A.S., Ganapathy A., Gwinn-Giglio M., Han C.S., Khouri H., Kiss H., Kothari S.P., Madupu R., Nelson K.E., Nelson W.C., Paulsen I., Penn K., Ren Q., Rosovitz M.J., Selengut J.D., Shrivastava S., Sullivan S.A., Tapia R., Thompson L.S., Watkins K.L., Yang Q., Yu C., Zafar N., Zhou L., Kuske C.R. Appl. Environ. Microbiol. 75:2046-2056(2009) [PubMed: 19201974] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Ellin345.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000360 Genomic DNA. Translation: ABF41462.1.
RefSeq	YP_591536.1. NC_008009.1.
3D structure databases
ProteinModelPortal	Q1INT8.
ModBase	Search...
Protein-protein interaction databases
STRING	Q1INT8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4072085.
GenomeReviews	Gene locus Acid345_2461 in contig CP000360_GR.
KEGG	aba:Acid345_2461.
NMPDR	fig|204669.6.peg.2449.
PATRIC	31981968. VBICanKor57425_2620.
Phylogenomic databases
eggNOG	COG0404.
HOGENOM	HBG299834.
OMA	KALYGGM.
PhylomeDB	Q1INT8.
ProtClustDB	PRK00389.
Enzyme and pathway databases
BioCyc	ABAC204669:ACID345_2461-MONOMER.
Family and domain databases
HAMAP	MF_00259. GcvT. [Tree]
InterPro	IPR013977. GCV_T_C. IPR006222. GCV_T_N. IPR006223. GcvT. IPR022903. NH2_Me_Trfase. [Graphical view]
KO	K00605.
PANTHER	PTHR13847:SF5. PTHR13847:SF5. 1 hit.
Pfam	PF01571. GCV_T. 1 hit. PF08669. GCV_T_C. 1 hit. [Graphical view]
PIRSF	PIRSF006487. GcvT. 1 hit.
TIGRFAMs	TIGR00528. GcvT. 1 hit.
ProtoNet	Search...

Entry information

Entry name

GCST_KORVE

Accession

Primary (citable) accession number: Q1INT8

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 28, 2009
Last sequence update:	June 13, 2006
Last modified:	January 25, 2012
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program