Q1INL4 (LPXB_KORVE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Lipid-A-disaccharide synthase
EC=2.4.1.182

Gene names

Name:	lpxB
Ordered Locus Names:	Acid345_2535

Organism

Koribacter versatilis (strain Ellin345)

Taxonomic identifier

204669 [NCBI]

Taxonomic lineage

Bacteria › Acidobacteria › Candidatus Koribacter

Protein attributes

Sequence length	382 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. HAMAP MF_00392
Catalytic activity	UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate. HAMAP MF_00392
Pathway	Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 5/6. HAMAP MF_00392
Sequence similarities	Belongs to the LpxB family.

Ontologies

Keywords
Biological process	Lipid A biosynthesis Lipid synthesis
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	lipid A biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	lipid-A-disaccharide synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 382	382	Lipid-A-disaccharide synthase HAMAP MF_00392		PRO_0000255156

Sequences

	Sequence		Length	Mass (Da)
	Q1INL4 [UniParc]. Last modified June 13, 2006. Version 1. Checksum: 1EF4EE2B4A40C91B	FASTA	382	42,297
	10 20 30 40 50 60 MLKVLISAGE ASGEMYGAAL LDALRKLSPD PVEAFGLGGE KMRAAGCDII VDSKDVAVVG 70 80 90 100 110 120 IAEVVAHLPR IYGEFHKLLR EADRRKPDVA VLIDFPDFHF RLAKALHARG IPVVYYVSPQ 130 140 150 160 170 180 LWAWRRGRIK LVQRYVKKML VIFPFEEQFY REHNVEAEFT GHPLGELSVT VDPRTEFAVR 190 200 210 220 230 240 YGLDPAKPWV GILPGSRRKE VQMILPTLID AAKKLGPANE YLLPVASTLD AGWMQAQLLA 250 260 270 280 290 300 IPQPPRVTLT SDARQTLVQS RAAMVASGTA TVEASVLGTP FVMVYRVAPL SWRVGRRLVK 310 320 330 340 350 360 LDRFAMPNLI AGREVVRELV QENFTADKVA AEVSALIEDG PRRAQVLKNL AEVREHLQSG 370 380 RTNESAAERA ARSVLSVAQR KD

References

[1]

"Three genomes from the phylum Acidobacteria provide insight into the lifestyles of these microorganisms in soils." Ward N.L., Challacombe J.F., Janssen P.H., Henrissat B., Coutinho P.M., Wu M., Xie G., Haft D.H., Sait M., Badger J., Barabote R.D., Bradley B., Brettin T.S., Brinkac L.M., Bruce D., Creasy T., Daugherty S.C., Davidsen T.M. , DeBoy R.T., Detter J.C., Dodson R.J., Durkin A.S., Ganapathy A., Gwinn-Giglio M., Han C.S., Khouri H., Kiss H., Kothari S.P., Madupu R., Nelson K.E., Nelson W.C., Paulsen I., Penn K., Ren Q., Rosovitz M.J., Selengut J.D., Shrivastava S., Sullivan S.A., Tapia R., Thompson L.S., Watkins K.L., Yang Q., Yu C., Zafar N., Zhou L., Kuske C.R. Appl. Environ. Microbiol. 75:2046-2056(2009) [PubMed: 19201974] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Ellin345.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000360 Genomic DNA. Translation: ABF41536.1.
RefSeq	YP_591610.1. NC_008009.1.
3D structure databases
ProteinModelPortal	Q1INL4.
ModBase	Search...
Protein-protein interaction databases
STRING	Q1INL4.
Protein family/group databases
CAZy	GT19. Glycosyltransferase Family 19.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4072179.
GenomeReviews	Gene locus Acid345_2535 in contig CP000360_GR.
KEGG	aba:Acid345_2535.
NMPDR	fig|204669.6.peg.2524.
PATRIC	31982126. VBICanKor57425_2699.
Phylogenomic databases
eggNOG	COG0763.
HOGENOM	HBG584837.
OMA	PDFNLGL.
PhylomeDB	Q1INL4.
ProtClustDB	CLSK774793.
Enzyme and pathway databases
BioCyc	ABAC204669:ACID345_2535-MONOMER.
Family and domain databases
HAMAP	MF_00392. LpxB. [Tree]
InterPro	IPR003835. Glyco_trans_19. [Graphical view]
KO	K00748.
Pfam	PF02684. LpxB. 1 hit. [Graphical view]
TIGRFAMs	TIGR00215. LpxB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

LPXB_KORVE

Accession

Primary (citable) accession number: Q1INL4

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
Last sequence update:	June 13, 2006
Last modified:	January 25, 2012
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program