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Q1INL4

- LPXB_KORVE

UniProt

Q1INL4 - LPXB_KORVE

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Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Koribacter versatilis (strain Ellin345)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciKVER204669:GHL8-2557-MONOMER.
UniPathwayiUPA00359; UER00481.

Protein family/group databases

CAZyiGT19. Glycosyltransferase Family 19.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthaseUniRule annotation (EC:2.4.1.182UniRule annotation)
Gene namesi
Name:lpxBUniRule annotation
Ordered Locus Names:Acid345_2535
OrganismiKoribacter versatilis (strain Ellin345)
Taxonomic identifieri204669 [NCBI]
Taxonomic lineageiBacteriaAcidobacteriaCandidatus Koribacter
ProteomesiUP000002432: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 382382Lipid-A-disaccharide synthasePRO_0000255156Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi204669.Acid345_2535.

Structurei

3D structure databases

ProteinModelPortaliQ1INL4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxB family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0763.
HOGENOMiHOG000018004.
KOiK00748.
OMAiTIYENAG.
OrthoDBiEOG6FBWZR.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1INL4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLKVLISAGE ASGEMYGAAL LDALRKLSPD PVEAFGLGGE KMRAAGCDII
60 70 80 90 100
VDSKDVAVVG IAEVVAHLPR IYGEFHKLLR EADRRKPDVA VLIDFPDFHF
110 120 130 140 150
RLAKALHARG IPVVYYVSPQ LWAWRRGRIK LVQRYVKKML VIFPFEEQFY
160 170 180 190 200
REHNVEAEFT GHPLGELSVT VDPRTEFAVR YGLDPAKPWV GILPGSRRKE
210 220 230 240 250
VQMILPTLID AAKKLGPANE YLLPVASTLD AGWMQAQLLA IPQPPRVTLT
260 270 280 290 300
SDARQTLVQS RAAMVASGTA TVEASVLGTP FVMVYRVAPL SWRVGRRLVK
310 320 330 340 350
LDRFAMPNLI AGREVVRELV QENFTADKVA AEVSALIEDG PRRAQVLKNL
360 370 380
AEVREHLQSG RTNESAAERA ARSVLSVAQR KD
Length:382
Mass (Da):42,297
Last modified:June 13, 2006 - v1
Checksum:i1EF4EE2B4A40C91B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000360 Genomic DNA. Translation: ABF41536.1.
RefSeqiYP_591610.1. NC_008009.1.

Genome annotation databases

EnsemblBacteriaiABF41536; ABF41536; Acid345_2535.
GeneIDi4072179.
KEGGiaba:Acid345_2535.
PATRICi31982126. VBICanKor57425_2699.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000360 Genomic DNA. Translation: ABF41536.1 .
RefSeqi YP_591610.1. NC_008009.1.

3D structure databases

ProteinModelPortali Q1INL4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 204669.Acid345_2535.

Protein family/group databases

CAZyi GT19. Glycosyltransferase Family 19.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABF41536 ; ABF41536 ; Acid345_2535 .
GeneIDi 4072179.
KEGGi aba:Acid345_2535.
PATRICi 31982126. VBICanKor57425_2699.

Phylogenomic databases

eggNOGi COG0763.
HOGENOMi HOG000018004.
KOi K00748.
OMAi TIYENAG.
OrthoDBi EOG6FBWZR.

Enzyme and pathway databases

UniPathwayi UPA00359 ; UER00481 .
BioCyci KVER204669:GHL8-2557-MONOMER.

Family and domain databases

HAMAPi MF_00392. LpxB.
InterProi IPR003835. Glyco_trans_19.
[Graphical view ]
Pfami PF02684. LpxB. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00215. lpxB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Ellin345.

Entry informationi

Entry nameiLPXB_KORVE
AccessioniPrimary (citable) accession number: Q1INL4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: June 13, 2006
Last modified: October 1, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3