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Q1INL4 (LPXB_KORVE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lipid-A-disaccharide synthase

EC=2.4.1.182
Gene names
Name:lpxB
Ordered Locus Names:Acid345_2535
OrganismKoribacter versatilis (strain Ellin345) [Reference proteome] [HAMAP]
Taxonomic identifier204669 [NCBI]
Taxonomic lineageBacteriaAcidobacteriaCandidatus Koribacter

Protein attributes

Sequence length382 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. HAMAP-Rule MF_00392

Catalytic activity

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate. HAMAP-Rule MF_00392

Pathway

Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 5/6. HAMAP-Rule MF_00392

Sequence similarities

Belongs to the LpxB family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 382382Lipid-A-disaccharide synthase HAMAP-Rule MF_00392
PRO_0000255156

Sequences

Sequence LengthMass (Da)Tools
Q1INL4 [UniParc].

Last modified June 13, 2006. Version 1.
Checksum: 1EF4EE2B4A40C91B

FASTA38242,297
        10         20         30         40         50         60 
MLKVLISAGE ASGEMYGAAL LDALRKLSPD PVEAFGLGGE KMRAAGCDII VDSKDVAVVG 

        70         80         90        100        110        120 
IAEVVAHLPR IYGEFHKLLR EADRRKPDVA VLIDFPDFHF RLAKALHARG IPVVYYVSPQ 

       130        140        150        160        170        180 
LWAWRRGRIK LVQRYVKKML VIFPFEEQFY REHNVEAEFT GHPLGELSVT VDPRTEFAVR 

       190        200        210        220        230        240 
YGLDPAKPWV GILPGSRRKE VQMILPTLID AAKKLGPANE YLLPVASTLD AGWMQAQLLA 

       250        260        270        280        290        300 
IPQPPRVTLT SDARQTLVQS RAAMVASGTA TVEASVLGTP FVMVYRVAPL SWRVGRRLVK 

       310        320        330        340        350        360 
LDRFAMPNLI AGREVVRELV QENFTADKVA AEVSALIEDG PRRAQVLKNL AEVREHLQSG 

       370        380 
RTNESAAERA ARSVLSVAQR KD 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000360 Genomic DNA. Translation: ABF41536.1.
RefSeqYP_591610.1. NC_008009.1.

3D structure databases

ProteinModelPortalQ1INL4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING204669.Acid345_2535.

Protein family/group databases

CAZyGT19. Glycosyltransferase Family 19.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABF41536; ABF41536; Acid345_2535.
GeneID4072179.
KEGGaba:Acid345_2535.
PATRIC31982126. VBICanKor57425_2699.

Phylogenomic databases

eggNOGCOG0763.
HOGENOMHOG000018004.
KOK00748.
OMATIYENAG.
OrthoDBEOG6FBWZR.

Enzyme and pathway databases

BioCycKVER204669:GHL8-2557-MONOMER.
UniPathwayUPA00359; UER00481.

Family and domain databases

HAMAPMF_00392. LpxB.
InterProIPR003835. Glyco_trans_19.
[Graphical view]
PfamPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsTIGR00215. lpxB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameLPXB_KORVE
AccessionPrimary (citable) accession number: Q1INL4
Entry history
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: June 13, 2006
Last modified: May 14, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways