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Q1INC3 (MTAP_KORVE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
S-methyl-5'-thioadenosine phosphorylase

EC=2.4.2.28
Alternative name(s):
5'-methylthioadenosine phosphorylase
Short name=MTA phosphorylase
Short name=MTAP
Gene names
Name:mtnP
Ordered Locus Names:Acid345_2626
OrganismKoribacter versatilis (strain Ellin345) [Reference proteome] [HAMAP]
Taxonomic identifier204669 [NCBI]
Taxonomic lineageBacteriaAcidobacteriaCandidatus Koribacter

Protein attributes

Sequence length292 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates By similarity. HAMAP-Rule MF_01963

Catalytic activity

S-methyl-5'-thioadenosine + phosphate = adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate. HAMAP-Rule MF_01963

Pathway

Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (phosphorylase route): step 1/1. HAMAP-Rule MF_01963

Subunit structure

Homohexamer. Dimer of a homotrimer By similarity. HAMAP-Rule MF_01963

Sequence similarities

Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 292292S-methyl-5'-thioadenosine phosphorylase HAMAP-Rule MF_01963
PRO_0000415094

Regions

Region53 – 542Phosphate binding By similarity
Region86 – 872Phosphate binding By similarity
Region208 – 2103Substrate binding By similarity

Sites

Binding site111Phosphate By similarity
Binding site1841Substrate; via amide nitrogen By similarity
Binding site1851Phosphate By similarity
Site1661Important for substrate specificity By similarity
Site2211Important for substrate specificity By similarity

Sequences

Sequence LengthMass (Da)Tools
Q1INC3 [UniParc].

Last modified June 13, 2006. Version 1.
Checksum: 49FB572E43B2BA15

FASTA29231,561
        10         20         30         40         50         60 
MQAEIGIIGG SGLYSMPGVS DVQEVRVTTP FGEPSDPYVL GTLAGRKVAF LARHGRGHRL 

        70         80         90        100        110        120 
LPTELNFRAN IHGFKQLGVE RIISVSAVGS LKEEHRPLEF VIPDQFYDRT KQRVSTFFGE 

       130        140        150        160        170        180 
GIVAHVGFGD PVCGEMAKVV KHATDKAGVV AKAGGTYVCM EGPQFSTKAE SNLYRSWGFD 

       190        200        210        220        230        240 
VIGMTNLQEA KLAREAELCY VTVAMVTDYD CWHPDHDAVT VDQIVAVLLK NAENACSVVR 

       250        260        270        280        290 
EAVAAMPKDR TCKCGSALAT AIITNKDVVP AATKEKLKLI IGKYFGEQKA GA 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000360 Genomic DNA. Translation: ABF41627.1.
RefSeqYP_591701.1. NC_008009.1.

3D structure databases

ProteinModelPortalQ1INC3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING204669.Acid345_2626.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABF41627; ABF41627; Acid345_2626.
GeneID4072035.
KEGGaba:Acid345_2626.
PATRIC31982322. VBICanKor57425_2797.

Phylogenomic databases

eggNOGCOG0005.
HOGENOMHOG000228986.
KOK00772.
OMACEAQLCY.
OrthoDBEOG6KHFXC.

Enzyme and pathway databases

BioCycKVER204669:GHL8-2648-MONOMER.
UniPathwayUPA00904; UER00873.

Family and domain databases

Gene3D3.40.50.1580. 1 hit.
HAMAPMF_01963. MTAP.
InterProIPR010044. MTAP.
IPR000845. Nucleoside_phosphorylase_d.
IPR001369. PNP/MTAP.
[Graphical view]
PANTHERPTHR11904. PTHR11904. 1 hit.
PfamPF01048. PNP_UDP_1. 1 hit.
[Graphical view]
SUPFAMSSF53167. SSF53167. 1 hit.
TIGRFAMsTIGR01694. MTAP. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMTAP_KORVE
AccessionPrimary (citable) accession number: Q1INC3
Entry history
Integrated into UniProtKB/Swiss-Prot: January 25, 2012
Last sequence update: June 13, 2006
Last modified: May 14, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways