Q1IMM1 (RNH2_KORVE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ribonuclease HII
Short name=RNase HII
EC=3.1.26.4

Gene names

Name:	rnhB
Ordered Locus Names:	Acid345_2878

Organism

Koribacter versatilis (strain Ellin345)

Taxonomic identifier

204669 [NCBI]

Taxonomic lineage

Bacteria › Acidobacteria › Candidatus Koribacter

Protein attributes

Sequence length	254 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Endonuclease that specifically degrades the RNA of RNA-DNA hybrids By similarity. HAMAP MF_00052_B
Catalytic activity	Endonucleolytic cleavage to 5'-phosphomonoester. HAMAP MF_00052_B
Cofactor	Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding By similarity.
Subcellular location	Cytoplasm Potential HAMAP MF_00052_B.
Sequence similarities	Belongs to the RNase HII family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Manganese Metal-binding
Molecular function	Endonuclease Hydrolase Nuclease
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	RNA binding Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW ribonuclease H activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 254	254	Ribonuclease HII HAMAP MF_00052_B		PRO_0000334851
Sites
	Metal binding	52	1	Divalent metal cation By similarity
	Metal binding	53	1	Divalent metal cation By similarity
	Metal binding	144	1	Divalent metal cation By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q1IMM1 [UniParc]. Last modified June 13, 2006. Version 1. Checksum: 704CBC571A277FE7	FASTA	254	27,764
	10 20 30 40 50 60 MVRPKKKPVL GKDGKPLSAA AAKLRLLKRL KCTTKYEKLA ADSGAKLIAG IDEVGRGALF 70 80 90 100 110 120 GPVVAAAVIL DPNYRIKGLR DSKLLPAETR EILSKRIREH CIAWSIAAVD VARIDQLNIY 130 140 150 160 170 180 WASNLAMKHA VRGLSCQPDH LLIDAMKLDL DCAQTPIIHG DALSASIAAA SIIAKVHRDA 190 200 210 220 230 240 LIREWAPIFP EYDLASNKGY SAPKHIKALR EFGPSPLHRQ SFAPVWMASA PQEVLEFMLE 250 ETADTAVPPE VLED

References

[1]

"Three genomes from the phylum Acidobacteria provide insight into the lifestyles of these microorganisms in soils." Ward N.L., Challacombe J.F., Janssen P.H., Henrissat B., Coutinho P.M., Wu M., Xie G., Haft D.H., Sait M., Badger J., Barabote R.D., Bradley B., Brettin T.S., Brinkac L.M., Bruce D., Creasy T., Daugherty S.C., Davidsen T.M. , DeBoy R.T., Detter J.C., Dodson R.J., Durkin A.S., Ganapathy A., Gwinn-Giglio M., Han C.S., Khouri H., Kiss H., Kothari S.P., Madupu R., Nelson K.E., Nelson W.C., Paulsen I., Penn K., Ren Q., Rosovitz M.J., Selengut J.D., Shrivastava S., Sullivan S.A., Tapia R., Thompson L.S., Watkins K.L., Yang Q., Yu C., Zafar N., Zhou L., Kuske C.R. Appl. Environ. Microbiol. 75:2046-2056(2009) [PubMed: 19201974] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Ellin345.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000360 Genomic DNA. Translation: ABF41879.1.
RefSeq	YP_591953.1. NC_008009.1.
3D structure databases
ProteinModelPortal	Q1IMM1.
ModBase	Search...
Protein-protein interaction databases
STRING	Q1IMM1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4071179.
GenomeReviews	Gene locus Acid345_2878 in contig CP000360_GR.
KEGG	aba:Acid345_2878.
NMPDR	fig|204669.6.peg.2871.
PATRIC	31982858. VBICanKor57425_3064.
Phylogenomic databases
eggNOG	COG0164.
HOGENOM	HBG584843.
OMA	RLGPTPI.
ProtClustDB	CLSK774867.
Enzyme and pathway databases
BioCyc	ABAC204669:ACID345_2878-MONOMER.
Family and domain databases
HAMAP	MF_00052_B. RNase_HII_B. [Tree]
InterPro	IPR022898. RNase_HII. IPR001352. RNase_HII/HIII. IPR024567. RNase_HII/HIII_dom. IPR012337. RNaseH-like_dom. [Graphical view]
KO	K03470.
PANTHER	PTHR10954. RNase_HII/HIII. 1 hit.
Pfam	PF01351. RNase_HII. 1 hit. [Graphical view]
SUPFAM	SSF53098. RNaseH_fold. 1 hit.
ProtoNet	Search...

Entry information

Entry name

RNH2_KORVE

Accession

Primary (citable) accession number: Q1IMM1

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	June 13, 2006
Last modified:	January 25, 2012
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program