Q1ILZ3 (ILVC_KORVE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ketol-acid reductoisomerase
EC=1.1.1.86

Alternative name(s):
Acetohydroxy-acid isomeroreductase
Alpha-keto-beta-hydroxylacil reductoisomerase

Gene names

Name:	ilvC
Ordered Locus Names:	Acid345_3106

Organism

Koribacter versatilis (strain Ellin345)

Taxonomic identifier

204669 [NCBI]

Taxonomic lineage

Bacteria › Acidobacteria › Candidatus Koribacter

Protein attributes

Sequence length	345 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	(R)-2,3-dihydroxy-3-methylbutanoate + NADP+ = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH. HAMAP MF_00435 (2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP+ = (S)-2-hydroxy-2-ethyl-3-oxobutanoate + NADPH. HAMAP MF_00435
Pathway	Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 2/4. HAMAP MF_00435 Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 2/4. HAMAP MF_00435
Sequence similarities	Belongs to the ketol-acid reductoisomerase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Branched-chain amino acid biosynthesis
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	branched chain family amino acid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	coenzyme binding Inferred from electronic annotation. Source: InterPro ketol-acid reductoisomerase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 345	345	Ketol-acid reductoisomerase HAMAP MF_00435		PRO_0000252747
Sites
	Active site	108	1	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q1ILZ3 [UniParc]. Last modified June 13, 2006. Version 1. Checksum: 9F67CE3A6EEA33CC	FASTA	345	37,685
	10 20 30 40 50 60 MAKVYHDSSA DLSIIRGKKV GIVGYGSQGH AHALNLVDSG VQVRVGLRPS SSSKAKAEKS 70 80 90 100 110 120 GLQVGSVSDV AQWADVIMIL APDTEQAAIY EKDIAPHLKP GKTLMFAHGF NIRYGTITPP 130 140 150 160 170 180 EGIDVSMVAP KAPGHRVREV FTEGGGTPAL FAIHQDASGK AREIALSYAA AIGTTRAGVL 190 200 210 220 230 240 ETTFKEETET DLFGEQAVLC GGAAALVKAG FETLVEAGYQ PELAYFECLH ELKLIVDLMY 250 260 270 280 290 300 RGGLNYMRYS VSDTAEYGDY IAGPRIITDE TRKNMKQLLT DIQDGTFAKN WINENKTGRP 310 320 330 340 WFEKKRTDEQ EQQLEDVGAQ LRDMMTFLNP VKIKQKSEQK EAVAQ

References

[1]

"Three genomes from the phylum Acidobacteria provide insight into the lifestyles of these microorganisms in soils." Ward N.L., Challacombe J.F., Janssen P.H., Henrissat B., Coutinho P.M., Wu M., Xie G., Haft D.H., Sait M., Badger J., Barabote R.D., Bradley B., Brettin T.S., Brinkac L.M., Bruce D., Creasy T., Daugherty S.C., Davidsen T.M. , DeBoy R.T., Detter J.C., Dodson R.J., Durkin A.S., Ganapathy A., Gwinn-Giglio M., Han C.S., Khouri H., Kiss H., Kothari S.P., Madupu R., Nelson K.E., Nelson W.C., Paulsen I., Penn K., Ren Q., Rosovitz M.J., Selengut J.D., Shrivastava S., Sullivan S.A., Tapia R., Thompson L.S., Watkins K.L., Yang Q., Yu C., Zafar N., Zhou L., Kuske C.R. Appl. Environ. Microbiol. 75:2046-2056(2009) [PubMed: 19201974] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Ellin345.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000360 Genomic DNA. Translation: ABF42107.1.
RefSeq	YP_592181.1. NC_008009.1.
3D structure databases
ProteinModelPortal	Q1ILZ3.
SMR	Q1ILZ3. Positions 3-328.
ModBase	Search...
Protein-protein interaction databases
STRING	Q1ILZ3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4072670.
GenomeReviews	Gene locus Acid345_3106 in contig CP000360_GR.
KEGG	aba:Acid345_3106.
NMPDR	fig|204669.6.peg.3109.
PATRIC	31983344. VBICanKor57425_3306.
Phylogenomic databases
eggNOG	COG0059.
HOGENOM	HBG286525.
OMA	MAYAKGI.
PhylomeDB	Q1ILZ3.
ProtClustDB	PRK05479.
Enzyme and pathway databases
BioCyc	ABAC204669:ACID345_3106-MONOMER.
Family and domain databases
HAMAP	MF_00435. IlvC. [Tree]
InterPro	IPR008927. 6-PGluconate_DH_C-like. IPR013023. AcH_isomrdctse. IPR000506. AcH_isomrdctse_C. IPR013328. DH_multihelical. IPR013116. IlvN. [Graphical view]
Gene3D	G3DSA:1.10.1040.10. Opine_DH. 1 hit.
KO	K00053.
PANTHER	PTHR21371. AcH_isomrdctse. 1 hit.
Pfam	PF01450. IlvC. 1 hit. PF07991. IlvN. 1 hit. [Graphical view]
SUPFAM	SSF48179. 6DGDH_C_like. 1 hit.
TIGRFAMs	TIGR00465. IlvC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ILVC_KORVE

Accession

Primary (citable) accession number: Q1ILZ3

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 17, 2006
Last sequence update:	June 13, 2006
Last modified:	January 25, 2012
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program