Reviewed, UniProtKB/Swiss-Prot Q1ILZ3 (ILVC_ACIBL)

Names and origin

Protein names

Recommended name:
    Ketol-acid reductoisomerase
    EC=1.1.1.86
Alternative name(s):
    Acetohydroxy-acid isomeroreductase
    Alpha-keto-beta-hydroxylacil reductoisomerase

Gene names

Name:	ilvC
Ordered Locus Names:	Acid345_3106

Organism

Acidobacteria bacterium (strain Ellin345) [Complete proteome] [HAMAP]

Taxonomic identifier

204669 [NCBI]

Taxonomic lineage

Bacteria › Acidobacteria › Acidobacteriales › Acidobacteriaceae

Protein attributes

Sequence length	345 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	(R)-2,3-dihydroxy-3-methylbutanoate + NADP(+) = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH. (2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP(+) = (S)-2-hydroxy-2-ethyl-3-oxobutanoate + NADPH.
Pathway	Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 2/4. Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 2/4.
Sequence similarities	Belongs to the ketol-acid reductoisomerase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Branched-chain amino acid biosynthesis
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	isoleucine biosynthetic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW valine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	binding Inferred from electronic annotation. Source: InterPro ketol-acid reductoisomerase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 345	345	Ketol-acid reductoisomerase		PRO_0000252747
Sites
	Active site	108	1	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q1ILZ3-1 [UniParc]. Last modified June 13, 2006. Version 1. Checksum: 9F67CE3A6EEA33CC	FASTA	345	37,685
	10 20 30 40 50 60 MAKVYHDSSA DLSIIRGKKV GIVGYGSQGH AHALNLVDSG VQVRVGLRPS SSSKAKAEKS 70 80 90 100 110 120 GLQVGSVSDV AQWADVIMIL APDTEQAAIY EKDIAPHLKP GKTLMFAHGF NIRYGTITPP 130 140 150 160 170 180 EGIDVSMVAP KAPGHRVREV FTEGGGTPAL FAIHQDASGK AREIALSYAA AIGTTRAGVL 190 200 210 220 230 240 ETTFKEETET DLFGEQAVLC GGAAALVKAG FETLVEAGYQ PELAYFECLH ELKLIVDLMY 250 260 270 280 290 300 RGGLNYMRYS VSDTAEYGDY IAGPRIITDE TRKNMKQLLT DIQDGTFAKN WINENKTGRP 310 320 330 340 WFEKKRTDEQ EQQLEDVGAQ LRDMMTFLNP VKIKQKSEQK EAVAQ

References

[1]

"Complete sequence of Acidobacteria bacterium Ellin345." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Brettin T., Bruce D., Han C., Tapia R., Kiss H., Gilna P., Schmutz J. , Larimer F., Land M., Hauser L., Kyrpides N., Lykidis A., Kuske C., Janssen P.H., Richardson P. Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000360 Genomic DNA. Translation: ABF42107.1.
RefSeq	YP_592181.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	4072670.
GenomeReviews	Gene locus Acid345_3106 in contig CP000360_GR.
KEGG	aba:Acid345_3106.
NMPDR	fig|204669.6.peg.3109.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q1ILZ3.
Family and domain databases
HAMAP	MF_00435. [Tree]
InterPro	IPR013023. AcH_isomrdctse. IPR000506. AcH_isomrdctse_C. IPR013116. IlvN. IPR016040. NAD(P)-bd. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR21371. AcH_isomrdctse. 1 hit.
Pfam	PF01450. IlvC. 1 hit. PF07991. IlvN. 1 hit. [Graphical view]
TIGRFAMs	TIGR00465. ilvC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ILVC_ACIBL

Accession

Primary (citable) accession number: Q1ILZ3

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 17, 2006
Last sequence update:	June 13, 2006
Last modified:	November 25, 2008
This is version 18 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)