Q1IJ49 (AHPD_KORVE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Alkyl hydroperoxide reductase AhpD
EC=1.11.1.15

Alternative name(s):
Alkylhydroperoxidase AhpD

Gene names

Name:	ahpD
Ordered Locus Names:	Acid345_4101

Organism

Koribacter versatilis (strain Ellin345)

Taxonomic identifier

204669 [NCBI]

Taxonomic lineage

Bacteria › Acidobacteria › Candidatus Koribacter

Protein attributes

Sequence length	194 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity By similarity. HAMAP MF_01676
Catalytic activity	2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH. HAMAP MF_01676
Sequence similarities	Belongs to the AhpD family.

Ontologies

Keywords
Domain	Redox-active center
Molecular function	Antioxidant Oxidoreductase Peroxidase
PTM	Disulfide bond
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular function	peroxidase activity Inferred from electronic annotation. Source: UniProtKB-KW peroxiredoxin activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 194	194	Alkyl hydroperoxide reductase AhpD HAMAP MF_01676		PRO_0000359467
Sites
	Active site	132	1	Proton donor By similarity
	Active site	135	1	Cysteine sulfenic acid (-SOH) intermediate By similarity
Amino acid modifications
	Disulfide bond	132 ↔ 135		Alternate By similarity
	Disulfide bond	135		Interchain (with AhpC); in linked form By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q1IJ49 [UniParc]. Last modified June 13, 2006. Version 1. Checksum: 05B71AF3B0362DBF	FASTA	194	21,187
	10 20 30 40 50 60 MNLEALLDTV PAYARDLKLN FSAVVRQNTE LTEQQLWGTV VACAAASRNR TLLDAIVEEA 70 80 90 100 110 120 KGKLSAQAVE AAKGAAAILS MNNIFYRFQH LAVNKKYETM RAGLRMNFLR QHGVDPLDFE 130 140 150 160 170 180 LWALAVSAVN GCGKCIDAHE RVLLQKEFSE EKILAAIRVA STIYGLAVVF DAEEPKGDLV 190 GAPVNTDAYS TTTI

References

[1]

"Three genomes from the phylum Acidobacteria provide insight into the lifestyles of these microorganisms in soils." Ward N.L., Challacombe J.F., Janssen P.H., Henrissat B., Coutinho P.M., Wu M., Xie G., Haft D.H., Sait M., Badger J., Barabote R.D., Bradley B., Brettin T.S., Brinkac L.M., Bruce D., Creasy T., Daugherty S.C., Davidsen T.M. , DeBoy R.T., Detter J.C., Dodson R.J., Durkin A.S., Ganapathy A., Gwinn-Giglio M., Han C.S., Khouri H., Kiss H., Kothari S.P., Madupu R., Nelson K.E., Nelson W.C., Paulsen I., Penn K., Ren Q., Rosovitz M.J., Selengut J.D., Shrivastava S., Sullivan S.A., Tapia R., Thompson L.S., Watkins K.L., Yang Q., Yu C., Zafar N., Zhou L., Kuske C.R. Appl. Environ. Microbiol. 75:2046-2056(2009) [PubMed: 19201974] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Ellin345.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000360 Genomic DNA. Translation: ABF43101.1.
RefSeq	YP_593175.1. NC_008009.1.
3D structure databases
ProteinModelPortal	Q1IJ49.
ModBase	Search...
Protein-protein interaction databases
STRING	Q1IJ49.
Protein family/group databases
PeroxiBase	4636. AbacAhpD.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4072292.
GenomeReviews	Gene locus Acid345_4101 in contig CP000360_GR.
KEGG	aba:Acid345_4101.
NMPDR	fig|204669.6.peg.4083.
PATRIC	31985512. VBICanKor57425_4377.
Phylogenomic databases
eggNOG	COG2128.
HOGENOM	HBG414634.
OMA	RAGLRMN.
ProtClustDB	CLSK775101.
Enzyme and pathway databases
BioCyc	ABAC204669:ACID345_4101-MONOMER.
Family and domain databases
HAMAP	MF_01676. AhpD. [Tree]
InterPro	IPR004674. AhpD. IPR004675. AhpD_core. IPR003779. CMD. [Graphical view]
KO	K04756.
Pfam	PF02627. CMD. 1 hit. [Graphical view]
TIGRFAMs	TIGR00777. AhpD. 1 hit. TIGR00778. AhpD_dom. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AHPD_KORVE

Accession

Primary (citable) accession number: Q1IJ49

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 20, 2009
Last sequence update:	June 13, 2006
Last modified:	January 25, 2012
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program