Reviewed, UniProtKB/Swiss-Prot Q1IIZ3 (ARLY_ACIBL)

Names and origin

Protein names

Recommended name:
    Argininosuccinate lyase
      Short name=ASAL
    EC=4.3.2.1
Alternative name(s):
    Arginosuccinase

Gene names

Name:	argH
Ordered Locus Names:	Acid345_4157

Organism

Acidobacteria bacterium (strain Ellin345) [Complete proteome] [HAMAP]

Taxonomic identifier

204669 [NCBI]

Taxonomic lineage

Bacteria › Acidobacteria › Candidatus Koribacter

Protein attributes

Sequence length	464 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	2-(N(omega)-L-arginino)succinate = fumarate + L-arginine. HAMAP MF_00006
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3. HAMAP MF_00006
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process via ornithine Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	argininosuccinate lyase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 464	464	Argininosuccinate lyase HAMAP MF_00006		PRO_0000321422

Sequences

	Sequence		Length	Mass (Da)
	Q1IIZ3-1 [UniParc]. Last modified June 13, 2006. Version 1. Checksum: 12F70F4180478389	FASTA	464	50,204
	10 20 30 40 50 60 MKMWSGRFSQ SLDPEFESWQ RSLPFDKKLL RHEVAASGAH ATALAKAGVL SSEELALIKS 70 80 90 100 110 120 GLAQIARDGA PDADDPSIED VHHFVESRLI EIAGEVGRKL HTGRSRNEQI ATDLRLYVRE 130 140 150 160 170 180 QIDETTLLIA DVIAALIERA ESVGEAAMPS YTHLQRAEPV LIAHWLLAYA EMFFRDITRL 190 200 210 220 230 240 ADCRKRANLC PLGSAAVAGT FVALDRGYIA TLLGFDAPTA NSIDATSDRD FAIEFVQSLS 250 260 270 280 290 300 VIGLHLSRMA EEMILFATTE FGFLQLPEQF ATGSSAMPQK KNPDSLELVR GKSAALLAHA 310 320 330 340 350 360 MQLAVTLKAL PLAYNKDMQE TQQPVFASAE ECIAMLRITA GFLRAVKFNT AVMHTAASTG 370 380 390 400 410 420 YMNAMAAAGY LVQQGIPFRR AHELIGAAVK LAVEKHCELH DLSADDLRNL GIAADDSFYA 430 440 450 460 ALQLPAVLAQ KNVAGGTAPN QVSTALKAAK KKLIAIGEVQ HVSA

References

[1]

"Three genomes from the phylum Acidobacteria provide insight into the lifestyles of these microorganisms in soils." Ward N.L., Challacombe J.F., Janssen P.H., Henrissat B., Coutinho P.M., Wu M., Xie G., Haft D.H., Sait M., Badger J., Barabote R.D., Bradley B., Brettin T.S., Brinkac L.M., Bruce D., Creasy T., Daugherty S.C., Davidsen T.M. , DeBoy R.T., Detter J.C., Dodson R.J., Durkin A.S., Ganapathy A., Gwinn-Giglio M., Han C.S., Khouri H., Kiss H., Kothari S.P., Madupu R., Nelson K.E., Nelson W.C., Paulsen I., Penn K., Ren Q., Rosovitz M.J., Selengut J.D., Shrivastava S., Sullivan S.A., Tapia R., Thompson L.S., Watkins K.L., Yang Q., Yu C., Zafar N., Zhou L., Kuske C.R. Appl. Environ. Microbiol. 75:2046-2056(2009) [PubMed: 19201974] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000360 Genomic DNA. Translation: ABF43157.1.
RefSeq	YP_593231.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q1IIZ3.
Genome annotation databases
GeneID	4072116.
GenomeReviews	Gene locus Acid345_4157 in contig CP000360_GR.
KEGG	aba:Acid345_4157.
NMPDR	fig|204669.6.peg.4138.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q1IIZ3.
OMA	MAEDLIF.
Family and domain databases
HAMAP	MF_00006. [Tree]
InterPro	IPR009049. Argininosuccinate_lyase. IPR003031. D_crystallin. IPR000362. Fumarate_lyase. IPR020557. Fumarate_lyase_CS. [Graphical view]
PANTHER	PTHR11444:SF3. argH. 1 hit.
Pfam	PF00206. Lyase_1. 1 hit. [Graphical view]
PRINTS	PR00145. ARGSUCLYASE. PR00149. FUMRATELYASE.
TIGRFAMs	TIGR00838. argH. 1 hit.
PROSITE	PS00163. FUMARATE_LYASES. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARLY_ACIBL

Accession

Primary (citable) accession number: Q1IIZ3

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	June 13, 2006
Last modified:	November 3, 2009
This is version 27 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)