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Protein

Methionyl-tRNA formyltransferase

Gene

fmt

Organism
Koribacter versatilis (strain Ellin345)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.UniRule annotation

Catalytic activityi

10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = tetrahydrofolate + N-formylmethionyl-tRNA(fMet).UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionTransferase
Biological processProtein biosynthesis

Enzyme and pathway databases

BioCyciCKOR204669:G1G6H-4391-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Methionyl-tRNA formyltransferaseUniRule annotation (EC:2.1.2.9UniRule annotation)
Gene namesi
Name:fmtUniRule annotation
Ordered Locus Names:Acid345_4228
OrganismiKoribacter versatilis (strain Ellin345)
Taxonomic identifieri204669 [NCBI]
Taxonomic lineageiBacteriaAcidobacteriaAcidobacterialesAcidobacteriaceaeCandidatus Koribacter
Proteomesi
  • UP000002432 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000772851 – 312Methionyl-tRNA formyltransferaseAdd BLAST312

Interactioni

Protein-protein interaction databases

STRINGi204669.Acid345_4228

Structurei

3D structure databases

ProteinModelPortaliQ1IIS2
SMRiQ1IIS2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni110 – 113Tetrahydrofolate (THF) bindingUniRule annotation4

Sequence similaritiesi

Belongs to the Fmt family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CAE Bacteria
COG0223 LUCA
HOGENOMiHOG000261177
KOiK00604
OMAiLRIVFMG
OrthoDBiPOG091H01YM

Family and domain databases

Gene3Di3.10.25.10, 1 hit
HAMAPiMF_00182 Formyl_trans, 1 hit
InterProiView protein in InterPro
IPR005794 Fmt
IPR005793 Formyl_trans_C
IPR037022 Formyl_trans_C_sf
IPR002376 Formyl_transf_N
IPR036477 Formyl_transf_N_sf
IPR011034 Formyl_transferase-like_C_sf
PfamiView protein in Pfam
PF02911 Formyl_trans_C, 1 hit
PF00551 Formyl_trans_N, 1 hit
SUPFAMiSSF50486 SSF50486, 1 hit
SSF53328 SSF53328, 1 hit
TIGRFAMsiTIGR00460 fmt, 1 hit

Sequencei

Sequence statusi: Complete.

Q1IIS2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MILVFCGTPR FAVPSLEHIV RAGHDVRLVV TQPDRPKGRG MGLAFSPVKD
60 70 80 90 100
AALALNLPVT QPEKIKNNEE FRAQLSAIAP DAIIVVGYGR IIPQWMIDLP
110 120 130 140 150
PLGNINVHAS LLPKYRGAAP IQWAIAMGEA VTGVTTMKID AGLDTGDMLL
160 170 180 190 200
QAEMPIAPED TSESLAPRLA ELGAELLVET LARLEGGVIA AVPQNHAEHT
210 220 230 240 250
LAPILKKEDG QIDFHRSAQE ILNRLRGFTP WPGAFTQFRG KGFFIHQARA
260 270 280 290 300
VAATLEPGEL RIEGENLLVG AGHNTALELL EIQLEGKKRM PARDFINGYR
310
PNSADKLGRL SS
Length:312
Mass (Da):33,821
Last modified:June 13, 2006 - v1
Checksum:iD9F460A8FADA9B83
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000360 Genomic DNA Translation: ABF43228.1
RefSeqiWP_011525027.1, NC_008009.1

Genome annotation databases

EnsemblBacteriaiABF43228; ABF43228; Acid345_4228
KEGGiaba:Acid345_4228

Similar proteinsi

Entry informationi

Entry nameiFMT_KORVE
AccessioniPrimary (citable) accession number: Q1IIS2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: June 13, 2006
Last modified: March 28, 2018
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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