Reviewed, UniProtKB/Swiss-Prot Q1IIL2 (AROC_ACIBL)

Names and origin

Protein names

Recommended name:
    Chorismate synthase
    EC=4.2.3.5
Alternative name(s):
    5-enolpyruvylshikimate-3-phosphate phospholyase

Gene names

Name:	aroC
Ordered Locus Names:	Acid345_4288

Organism

Acidobacteria bacterium (strain Ellin345) [Complete proteome] [HAMAP]

Taxonomic identifier

204669 [NCBI]

Taxonomic lineage

Bacteria › Acidobacteria › Candidatus Koribacter

Protein attributes

Sequence length	393 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate. HAMAP MF_00300
Cofactor	Reduced flavin By similarity.
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7. HAMAP MF_00300
Subunit structure	Homotetramer By similarity.
Sequence similarities	Belongs to the chorismate synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	chorismate synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 393	393	Chorismate synthase HAMAP MF_00300		PRO_0000322379

Sequences

	Sequence		Length	Mass (Da)
	Q1IIL2-1 [UniParc]. Last modified June 13, 2006. Version 1. Checksum: EABD4A7C06D3674D	FASTA	393	42,575
	10 20 30 40 50 60 MLRFQTAGES HGEALVATLT GVPAGLPIDQ AFLDRELWRR QQGFGRGGRM KIERDTAHIL 70 80 90 100 110 120 SGVHHGKTIG SPIAILIRNN DWKNWQESLP VEEGDSAKHK PVKSPRPGHA DLAGALKYNF 130 140 150 160 170 180 PEARYVLERA SARETTARVA AGAIAKLLLR QIGADVLSHV IAVGTARLEN TEVQWEKLVE 190 200 210 220 230 240 LAQRDNVLLG CVDPEAEQRM KEQVDQVLRT GDTVGGVFEV VAHNLPPGLG TYVEWDRRLD 250 260 270 280 290 300 GLLAMAVMSL QAVKAVEIGE GVSVAATFGS GAQDEIGYER EHESKFTGFT RTSNHAGGIE 310 320 330 340 350 360 GGVSNGQDIL VRGYLKPIST LRRPLGSVDF ATREPLKAAY ERSDVCVVPA AGIAAEAMVA 370 380 390 ITLAGCALEK FGGDSLVEFK RNYEGYCQQL QSF

References

[1]

"Three genomes from the phylum Acidobacteria provide insight into the lifestyles of these microorganisms in soils." Ward N.L., Challacombe J.F., Janssen P.H., Henrissat B., Coutinho P.M., Wu M., Xie G., Haft D.H., Sait M., Badger J., Barabote R.D., Bradley B., Brettin T.S., Brinkac L.M., Bruce D., Creasy T., Daugherty S.C., Davidsen T.M. , DeBoy R.T., Detter J.C., Dodson R.J., Durkin A.S., Ganapathy A., Gwinn-Giglio M., Han C.S., Khouri H., Kiss H., Kothari S.P., Madupu R., Nelson K.E., Nelson W.C., Paulsen I., Penn K., Ren Q., Rosovitz M.J., Selengut J.D., Shrivastava S., Sullivan S.A., Tapia R., Thompson L.S., Watkins K.L., Yang Q., Yu C., Zafar N., Zhou L., Kuske C.R. Appl. Environ. Microbiol. 75:2046-2056(2009) [PubMed: 19201974] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000360 Genomic DNA. Translation: ABF43288.1.
RefSeq	YP_593362.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q1IIL2.
Genome annotation databases
GeneID	4071861.
GenomeReviews	Gene locus Acid345_4288 in contig CP000360_GR.
KEGG	aba:Acid345_4288.
NMPDR	fig|204669.6.peg.4265.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q1IIL2.
OMA	PPGLGSH.
Family and domain databases
HAMAP	MF_00300. [Tree]
InterPro	IPR000453. Chorismate_synth. IPR020541. Chorismate_synthase_CS. [Graphical view]
PANTHER	PTHR21085. Chorismate_synth. 1 hit.
Pfam	PF01264. Chorismate_synt. 1 hit. [Graphical view]
PIRSF	PIRSF001456. Chorismate_synth. 1 hit.
ProDom	PD002941. Chorismate_synth. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00033. aroC. 1 hit.
PROSITE	PS00787. CHORISMATE_SYNTHASE_1. 1 hit. PS00788. CHORISMATE_SYNTHASE_2. 1 hit. PS00789. CHORISMATE_SYNTHASE_3. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROC_ACIBL

Accession

Primary (citable) accession number: Q1IIL2

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	June 13, 2006
Last modified:	November 3, 2009
This is version 24 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)