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Protein

Release factor glutamine methyltransferase

Gene

prmC

Organism
Koribacter versatilis (strain Ellin345)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + [peptide chain release factor 1 or 2]-L-glutamine = S-adenosyl-L-homocysteine + [peptide chain release factor 1 or 2]-N(5)-methyl-L-glutamine.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei143S-adenosyl-L-methionineUniRule annotation1
Binding sitei186S-adenosyl-L-methionineUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Ligandi

S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Release factor glutamine methyltransferaseUniRule annotation (EC:2.1.1.297UniRule annotation)
Short name:
RF MTaseUniRule annotation
Alternative name(s):
N5-glutamine methyltransferase PrmCUniRule annotation
Protein-(glutamine-N5) MTase PrmCUniRule annotation
Protein-glutamine N-methyltransferase PrmCUniRule annotation
Gene namesi
Name:prmCUniRule annotation
Ordered Locus Names:Acid345_4471
OrganismiKoribacter versatilis (strain Ellin345)
Taxonomic identifieri204669 [NCBI]
Taxonomic lineageiBacteriaAcidobacteriaAcidobacterialesAcidobacteriaceaeCandidatus Koribacter
Proteomesi
  • UP000002432 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004145261 – 280Release factor glutamine methyltransferaseAdd BLAST280

Interactioni

Protein-protein interaction databases

STRINGi204669.Acid345_4471.

Structurei

3D structure databases

ProteinModelPortaliQ1II29.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni120 – 124S-adenosyl-L-methionine bindingUniRule annotation5
Regioni186 – 189Substrate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105EQY. Bacteria.
COG2890. LUCA.
HOGENOMiHOG000076274.
KOiK02493.
OMAiILGAWEF.
OrthoDBiPOG091H02CJ.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_02126. RF_methyltr_PrmC. 1 hit.
InterProiIPR002052. DNA_methylase_N6_adenine_CS.
IPR004556. Modification_methylase_HemK.
IPR019874. Release_fac_Glu-N5_MeTfrase.
IPR029063. SAM-dependent_MTases.
IPR007848. Small_mtfrase_dom.
[Graphical view]
PfamiPF05175. MTS. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00536. hemK_fam. 1 hit.
TIGR03534. RF_mod_PrmC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1II29-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLKQAFDSA LKHLEAADTP SPRLSAELLL MFSLNCDRAY LFTYPERELT
60 70 80 90 100
ADEQARYDEA IARRCHGEPA QYITGHQEFY GRDFLVSPAV LIPRPETEHL
110 120 130 140 150
IEAVLELAPR EVRWEVLDVG TGSGCIAATL AKEFPRMKVT AVDISPEALQ
160 170 180 190 200
IAQANAARLE AQVEFRVSDL LSAIEPGRQF DMIVSNPPYV GECEADKVQR
210 220 230 240 250
QVKDFEPHCA VFGGERGMDI IKRLAPQVWE HLKPGGWFLM EIGYSIADPV
260 270 280
HEIMRDWTNF KVVPDLRGIP RVVVGRKPTS
Length:280
Mass (Da):31,472
Last modified:June 13, 2006 - v1
Checksum:i1FAD1120B788E3B6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000360 Genomic DNA. Translation: ABF43471.1.
RefSeqiWP_011525268.1. NC_008009.1.

Genome annotation databases

EnsemblBacteriaiABF43471; ABF43471; Acid345_4471.
KEGGiaba:Acid345_4471.
PATRICi31986335. VBICanKor57425_4780.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000360 Genomic DNA. Translation: ABF43471.1.
RefSeqiWP_011525268.1. NC_008009.1.

3D structure databases

ProteinModelPortaliQ1II29.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi204669.Acid345_4471.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABF43471; ABF43471; Acid345_4471.
KEGGiaba:Acid345_4471.
PATRICi31986335. VBICanKor57425_4780.

Phylogenomic databases

eggNOGiENOG4105EQY. Bacteria.
COG2890. LUCA.
HOGENOMiHOG000076274.
KOiK02493.
OMAiILGAWEF.
OrthoDBiPOG091H02CJ.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_02126. RF_methyltr_PrmC. 1 hit.
InterProiIPR002052. DNA_methylase_N6_adenine_CS.
IPR004556. Modification_methylase_HemK.
IPR019874. Release_fac_Glu-N5_MeTfrase.
IPR029063. SAM-dependent_MTases.
IPR007848. Small_mtfrase_dom.
[Graphical view]
PfamiPF05175. MTS. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00536. hemK_fam. 1 hit.
TIGR03534. RF_mod_PrmC. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPRMC_KORVE
AccessioniPrimary (citable) accession number: Q1II29
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 14, 2011
Last sequence update: June 13, 2006
Last modified: November 2, 2016
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.