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Q1IHV2

- GSA_KORVE

UniProt

Q1IHV2 - GSA_KORVE

Protein

Glutamate-1-semialdehyde 2,1-aminomutase

Gene

hemL

Organism
Koribacter versatilis (strain Ellin345)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 1 (13 Jun 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    (S)-4-amino-5-oxopentanoate = 5-aminolevulinate.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. glutamate-1-semialdehyde 2,1-aminomutase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: InterPro
    3. transaminase activity Source: InterPro

    GO - Biological processi

    1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Porphyrin biosynthesis

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciKVER204669:GHL8-4595-MONOMER.
    UniPathwayiUPA00251; UER00317.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamate-1-semialdehyde 2,1-aminomutaseUniRule annotation (EC:5.4.3.8UniRule annotation)
    Short name:
    GSAUniRule annotation
    Alternative name(s):
    Glutamate-1-semialdehyde aminotransferaseUniRule annotation
    Short name:
    GSA-ATUniRule annotation
    Gene namesi
    Name:hemLUniRule annotation
    Ordered Locus Names:Acid345_4548
    OrganismiKoribacter versatilis (strain Ellin345)
    Taxonomic identifieri204669 [NCBI]
    Taxonomic lineageiBacteriaAcidobacteriaCandidatus Koribacter
    ProteomesiUP000002432: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 431431Glutamate-1-semialdehyde 2,1-aminomutasePRO_0000382243Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei269 – 2691N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi204669.Acid345_4548.

    Structurei

    3D structure databases

    ProteinModelPortaliQ1IHV2.
    SMRiQ1IHV2. Positions 6-427.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0001.
    HOGENOMiHOG000020210.
    KOiK01845.
    OMAiLMAHIAP.
    OrthoDBiEOG6QVRHN.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 2 hits.
    HAMAPiMF_00375. HemL_aminotrans_3.
    InterProiIPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
    IPR005814. Aminotrans_3.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PANTHERiPTHR11986. PTHR11986. 1 hit.
    PfamiPF00202. Aminotran_3. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
    SUPFAMiSSF53383. SSF53383. 1 hit.
    TIGRFAMsiTIGR00713. hemL. 1 hit.
    PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q1IHV2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSRKLDRSRE LQKRAEALIP GGVNSPVRAF RAVGGEPPIL VRGEGARVFD    50
    ADGNGYIDYV LSWGPLILGH AFTPVINAIE KAAEKGTSFG ASTPTEADLA 100
    EAVVHAMPAI EKIRFVSSGT EATMSAIRLA RGFTGRKYIV KFEGCYHGHS 150
    DSLLVKAGSG VATLGIPGSA GVPDELAQLT LALPYNNVAA VEQAFTKFKG 200
    QIACVIVEPI VGNMGCVPPA ADYLQALSDI TKREGAVLIV DEVMTGFRVA 250
    YGGAQELYGL KPDLVTLGKI IGGGLPVAAY GGRKDIMDKI APLGPVYQAG 300
    TLSGNPLAMA AGLAMLCHLR DNAMEIYPRL DQLSADLVNR VLDAAREAGV 350
    ALTANRVGSM FTWFFTDKHV TDWDSAATCD TKQFGQFHGA MLDAGVWLPP 400
    AQFEAAFLSS AHTEQDIDDT VAAAREAFAI L 431
    Length:431
    Mass (Da):45,581
    Last modified:June 13, 2006 - v1
    Checksum:i22324CA599B78F39
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000360 Genomic DNA. Translation: ABF43548.1.
    RefSeqiYP_593622.1. NC_008009.1.

    Genome annotation databases

    EnsemblBacteriaiABF43548; ABF43548; Acid345_4548.
    GeneIDi4071493.
    KEGGiaba:Acid345_4548.
    PATRICi31986495. VBICanKor57425_4859.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000360 Genomic DNA. Translation: ABF43548.1 .
    RefSeqi YP_593622.1. NC_008009.1.

    3D structure databases

    ProteinModelPortali Q1IHV2.
    SMRi Q1IHV2. Positions 6-427.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 204669.Acid345_4548.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABF43548 ; ABF43548 ; Acid345_4548 .
    GeneIDi 4071493.
    KEGGi aba:Acid345_4548.
    PATRICi 31986495. VBICanKor57425_4859.

    Phylogenomic databases

    eggNOGi COG0001.
    HOGENOMi HOG000020210.
    KOi K01845.
    OMAi LMAHIAP.
    OrthoDBi EOG6QVRHN.

    Enzyme and pathway databases

    UniPathwayi UPA00251 ; UER00317 .
    BioCyci KVER204669:GHL8-4595-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 2 hits.
    HAMAPi MF_00375. HemL_aminotrans_3.
    InterProi IPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
    IPR005814. Aminotrans_3.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    PANTHERi PTHR11986. PTHR11986. 1 hit.
    Pfami PF00202. Aminotran_3. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
    SUPFAMi SSF53383. SSF53383. 1 hit.
    TIGRFAMsi TIGR00713. hemL. 1 hit.
    PROSITEi PS00600. AA_TRANSFER_CLASS_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Ellin345.

    Entry informationi

    Entry nameiGSA_KORVE
    AccessioniPrimary (citable) accession number: Q1IHV2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 1, 2009
    Last sequence update: June 13, 2006
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3