Reviewed, UniProtKB/Swiss-Prot Q1IHT1 (PYRB_ACIBL)

Names and origin

Protein names

Recommended name:
    Aspartate carbamoyltransferase
    EC=2.1.3.2
Alternative name(s):
    Aspartate transcarbamylase
      Short name=ATCase

Gene names

Name:	pyrB
Ordered Locus Names:	Acid345_4569

Organism

Acidobacteria bacterium (strain Ellin345) [Complete proteome] [HAMAP]

Taxonomic identifier

204669 [NCBI]

Taxonomic lineage

Bacteria › Acidobacteria › Acidobacteriales › Acidobacteriaceae

Protein attributes

Sequence length	303 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate.
Pathway	Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from HCO(3)(-): step 2/6.
Sequence similarities	Belongs to the ATCase/OTCase family.

Ontologies

Keywords
Biological process	Pyrimidine biosynthesis
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	'de novo' pyrimidine base biosynthetic process Inferred from electronic annotation. Source: InterPro amino acid metabolic process Inferred from electronic annotation. Source: InterPro pyrimidine nucleotide biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	amino acid binding Inferred from electronic annotation. Source: InterPro aspartate carbamoyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 303	303	Aspartate carbamoyltransferase		PRO_0000321060

Sequences

	Sequence		Length	Mass (Da)
	Q1IHT1-1 [UniParc]. Last modified June 13, 2006. Version 1. Checksum: 0DC0A7EBDE8BF177	FASTA	303	32,838
	10 20 30 40 50 60 MKSKKPRSLL GIEGMESKEI NALLKLAARM EPTRRRNTLR GKTVVLLFYE NSTRTRSSFE 70 80 90 100 110 120 LAAKVLGATT ILITATASSI EKGESLIDTG YTVRALGADA IVMRHPSSGA HWLLAEHLDI 130 140 150 160 170 180 PIINAGDGMH EHPSQGLLDA LTILQAKKKF KGLKIAIVGD IYHSRVARSN VHLLPKLGAK 190 200 210 220 230 240 VVLCGPPDLC PDEMAKIASG IEVSHNLDHA LSGADVVMSL RVQKERLVGR QIGVEDYIAN 250 260 270 280 290 300 YQITPEKLAL AKKDAVLMHP GPIIRGMELT SEVADGHASK ILAQVHNGVK VRMAILQTLL AKN

References

[1]

"Complete sequence of Acidobacteria bacterium Ellin345." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Brettin T., Bruce D., Han C., Tapia R., Kiss H., Gilna P., Schmutz J. , Larimer F., Land M., Hauser L., Kyrpides N., Lykidis A., Kuske C., Janssen P.H., Richardson P. Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000360 Genomic DNA. Translation: ABF43569.1.
RefSeq	YP_593643.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	4071514.
GenomeReviews	Gene locus Acid345_4569 in contig CP000360_GR.
KEGG	aba:Acid345_4569.
NMPDR	fig|204669.6.peg.4546.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q1IHT1.
Family and domain databases
HAMAP	MF_00001. [Tree]
InterPro	IPR006130. Asp/Orn_carbamoyltranf. IPR006132. Asp/Orn_carbamoyltranf_P_bd. IPR006131. Asp_carbamoyltransf_Asp/Orn_bd. IPR002082. Aspartate_carbamoyltransf_euk. [Graphical view]
Pfam	PF00185. OTCace. 1 hit. PF02729. OTCace_N. 1 hit. [Graphical view]
PRINTS	PR00100. AOTCASE. PR00101. ATCASE.
TIGRFAMs	TIGR00670. asp_carb_tr. 1 hit.
PROSITE	PS00097. CARBAMOYLTRANSFERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PYRB_ACIBL

Accession

Primary (citable) accession number: Q1IHT1

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	June 13, 2006
Last modified:	November 25, 2008
This is version 22 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)