Q1IHQ3 (SYN_KORVE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Asparagine--tRNA ligase
EC=6.1.1.22

Alternative name(s):
Asparaginyl-tRNA synthetase
Short name=AsnRS

Gene names

Name:	asnS
Ordered Locus Names:	Acid345_4597

Organism

Koribacter versatilis (strain Ellin345)

Taxonomic identifier

204669 [NCBI]

Taxonomic lineage

Bacteria › Acidobacteria › Candidatus Koribacter

Protein attributes

Sequence length	442 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + L-asparagine + tRNA(Asn) = AMP + diphosphate + L-asparaginyl-tRNA(Asn). HAMAP MF_00534
Subunit structure	Homodimer By similarity. HAMAP MF_00534
Subcellular location	Cytoplasm HAMAP MF_00534.
Sequence similarities	Belongs to the class-II aminoacyl-tRNA synthetase family.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Aminoacyl-tRNA synthetase Ligase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	asparaginyl-tRNA aminoacylation Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW asparagine-tRNA ligase activity Inferred from electronic annotation. Source: EC nucleic acid binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 442	442	Asparagine--tRNA ligase HAMAP MF_00534		PRO_1000072527

Sequences

	Sequence		Length	Mass (Da)
	Q1IHQ3 [UniParc]. Last modified June 13, 2006. Version 1. Checksum: 0B8D70FBB25C76D3	FASTA	442	50,283
	10 20 30 40 50 60 MEQAPVSTIH EIGKHDGQSV TIKGWLYNLR ESGKLLFPIF RDGTGLLQGV LFKKNVSPEL 70 80 90 100 110 120 FDLVKNLTQE SSVIVTGNVR AEQRAPGGYE MDVTALEVVQ RVPENEPYPI TPKEHGIEFL 130 140 150 160 170 180 MEHRHLWVRS QRQAAILRIR GEIVRSAHEF FDKQGFTLTE PPILTPAACE GTSTLFPVDY 190 200 210 220 230 240 FGDPAFLTQS GQLYIEATAM ALGKVYSFGP TFRAEKSKTR RHLTEFWMVE PEVAFAELDD 250 260 270 280 290 300 IMKLAEDFIT HIVKSVLERR RDDLKTIERD LSKLENIDTP FPRISYDEAV QMLQEGHAKG 310 320 330 340 350 360 ELESRFEWGG DLGSPDETYI SSKFDRPVMI HRYPVEVKAF YMEPDPNNSK VALCVDVLAP 370 380 390 400 410 420 EGYGEVIGGS QRMGSYEKLL ARIHEHQLPE ESFKWYLDLR KFGGVPHSGF GMGIERAVAW 430 440 ICGLDHVRET IPFARTLHRI YP

References

[1]

"Three genomes from the phylum Acidobacteria provide insight into the lifestyles of these microorganisms in soils." Ward N.L., Challacombe J.F., Janssen P.H., Henrissat B., Coutinho P.M., Wu M., Xie G., Haft D.H., Sait M., Badger J., Barabote R.D., Bradley B., Brettin T.S., Brinkac L.M., Bruce D., Creasy T., Daugherty S.C., Davidsen T.M. , DeBoy R.T., Detter J.C., Dodson R.J., Durkin A.S., Ganapathy A., Gwinn-Giglio M., Han C.S., Khouri H., Kiss H., Kothari S.P., Madupu R., Nelson K.E., Nelson W.C., Paulsen I., Penn K., Ren Q., Rosovitz M.J., Selengut J.D., Shrivastava S., Sullivan S.A., Tapia R., Thompson L.S., Watkins K.L., Yang Q., Yu C., Zafar N., Zhou L., Kuske C.R. Appl. Environ. Microbiol. 75:2046-2056(2009) [PubMed: 19201974] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Ellin345.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000360 Genomic DNA. Translation: ABF43597.1.
RefSeq	YP_593671.1. NC_008009.1.
3D structure databases
ProteinModelPortal	Q1IHQ3.
ModBase	Search...
Protein-protein interaction databases
STRING	Q1IHQ3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4071542.
GenomeReviews	Gene locus Acid345_4597 in contig CP000360_GR.
KEGG	aba:Acid345_4597.
NMPDR	fig|204669.6.peg.4573.
PATRIC	31986597. VBICanKor57425_4910.
Phylogenomic databases
eggNOG	COG0017.
HOGENOM	HBG745843.
OMA	DHLPQET.
PhylomeDB	Q1IHQ3.
ProtClustDB	PRK03932.
Enzyme and pathway databases
BioCyc	ABAC204669:ACID345_4597-MONOMER.
Family and domain databases
HAMAP	MF_00534. Asn_tRNA_synth. [Tree]
InterPro	IPR004364. aa-tRNA-synt_II. IPR018150. aa-tRNA-synt_II-like. IPR006195. aa-tRNA-synth_II. IPR004522. Asn-tRNA-synth_IIb. IPR002312. Asp/Asn-tRNA-synth_IIb. IPR012340. NA-bd_OB-fold. IPR016027. NA-bd_OB-fold-like. IPR004365. NA-bd_OB_tRNA-helicase. [Graphical view]
Gene3D	G3DSA:2.40.50.140. OB_NA_bd_sub. 1 hit.
KO	K01893.
PANTHER	PTHR22594. aa-tRNA-synt_II. 1 hit. PTHR22594:SF6. PTHR22594:SF6. 1 hit.
Pfam	PF00152. tRNA-synt_2. 1 hit. PF01336. tRNA_anti. 1 hit. [Graphical view]
PRINTS	PR01042. TRNASYNTHASP.
SUPFAM	SSF50249. Nucleic_acid_OB. 1 hit.
TIGRFAMs	TIGR00457. AsnS. 1 hit.
PROSITE	PS50862. AA_TRNA_LIGASE_II. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SYN_KORVE

Accession

Primary (citable) accession number: Q1IHQ3

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	June 13, 2006
Last modified:	January 25, 2012
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program