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Q1IHA8

- PANC_KORVE

UniProt

Q1IHA8 - PANC_KORVE

Protein

Pantothenate synthetase

Gene

panC

Organism
Koribacter versatilis (strain Ellin345)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 50 (01 Oct 2014)
      Sequence version 1 (13 Jun 2006)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.UniRule annotation

    Catalytic activityi

    ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei37 – 371Proton donorUniRule annotation
    Binding sitei61 – 611Beta-alanineUniRule annotation
    Binding sitei61 – 611PantoateUniRule annotation
    Binding sitei153 – 1531PantoateUniRule annotation
    Binding sitei176 – 1761ATP; via amide nitrogen and carbonyl oxygenUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi30 – 378ATPUniRule annotation
    Nucleotide bindingi147 – 1504ATPUniRule annotation
    Nucleotide bindingi184 – 1874ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. pantoate-beta-alanine ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. pantothenate biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Pantothenate biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciKVER204669:GHL8-4794-MONOMER.
    UniPathwayiUPA00028; UER00005.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pantothenate synthetaseUniRule annotation (EC:6.3.2.1UniRule annotation)
    Short name:
    PSUniRule annotation
    Alternative name(s):
    Pantoate--beta-alanine ligaseUniRule annotation
    Pantoate-activating enzymeUniRule annotation
    Gene namesi
    Name:panCUniRule annotation
    Ordered Locus Names:Acid345_4743
    OrganismiKoribacter versatilis (strain Ellin345)
    Taxonomic identifieri204669 [NCBI]
    Taxonomic lineageiBacteriaAcidobacteriaCandidatus Koribacter
    ProteomesiUP000002432: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 291291Pantothenate synthetasePRO_0000305381Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi204669.Acid345_4743.

    Structurei

    3D structure databases

    ProteinModelPortaliQ1IHA8.
    SMRiQ1IHA8. Positions 1-279.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the pantothenate synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0414.
    HOGENOMiHOG000175516.
    KOiK01918.
    OMAiECPIVRE.
    OrthoDBiEOG6Z6FZ4.

    Family and domain databases

    Gene3Di3.40.50.620. 1 hit.
    HAMAPiMF_00158. PanC.
    InterProiIPR004821. Cyt_trans-like.
    IPR003721. Pantoate_ligase.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PANTHERiPTHR21299:SF1. PTHR21299:SF1. 1 hit.
    PfamiPF02569. Pantoate_ligase. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00125. cyt_tran_rel. 1 hit.
    TIGR00018. panC. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q1IHA8-1 [UniParc]FASTAAdd to Basket

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    MRVVRTIAEM QAICRTLHRE GKSIGLVPTM GALHAGHISL VRTARTQNDS    50
    VVVSIFVNPI QFGPNEDLAK YPRTFEQDCA QLDHEGVDFV FSPGVEEMYP 100
    EGTATFVHVD GLSEKLDGRS RPGHFKGVTT VVSKLFHIIP ADHAYFGQKD 150
    AAQVAVIRKM VRDQNFDIDL MICPIVREKD GLALSSRNAY LDPTQRQQAL 200
    VLHRALMRVQ MLADTGHTDA YYLAEAGRAV IAEEPGAKLD YLEIVDPNTL 250
    EPITEIGKGA LVAVAAQIGN TRLIDNLVLQ AAGNARGPRT S 291
    Length:291
    Mass (Da):31,878
    Last modified:June 13, 2006 - v1
    Checksum:i5250848795BD6034
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000360 Genomic DNA. Translation: ABF43742.1.
    RefSeqiYP_593816.1. NC_008009.1.

    Genome annotation databases

    EnsemblBacteriaiABF43742; ABF43742; Acid345_4743.
    GeneIDi4070681.
    KEGGiaba:Acid345_4743.
    PATRICi31986925. VBICanKor57425_5069.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000360 Genomic DNA. Translation: ABF43742.1 .
    RefSeqi YP_593816.1. NC_008009.1.

    3D structure databases

    ProteinModelPortali Q1IHA8.
    SMRi Q1IHA8. Positions 1-279.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 204669.Acid345_4743.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABF43742 ; ABF43742 ; Acid345_4743 .
    GeneIDi 4070681.
    KEGGi aba:Acid345_4743.
    PATRICi 31986925. VBICanKor57425_5069.

    Phylogenomic databases

    eggNOGi COG0414.
    HOGENOMi HOG000175516.
    KOi K01918.
    OMAi ECPIVRE.
    OrthoDBi EOG6Z6FZ4.

    Enzyme and pathway databases

    UniPathwayi UPA00028 ; UER00005 .
    BioCyci KVER204669:GHL8-4794-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.620. 1 hit.
    HAMAPi MF_00158. PanC.
    InterProi IPR004821. Cyt_trans-like.
    IPR003721. Pantoate_ligase.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    PANTHERi PTHR21299:SF1. PTHR21299:SF1. 1 hit.
    Pfami PF02569. Pantoate_ligase. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00125. cyt_tran_rel. 1 hit.
    TIGR00018. panC. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Ellin345.

    Entry informationi

    Entry nameiPANC_KORVE
    AccessioniPrimary (citable) accession number: Q1IHA8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 2, 2007
    Last sequence update: June 13, 2006
    Last modified: October 1, 2014
    This is version 50 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    The reaction proceeds by a bi uni uni bi ping pong mechanism.UniRule annotation

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3