Q1IG70 (BETA_PSEE4) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Choline dehydrogenase
Short name=CDH
Short name=CHD
EC=1.1.99.1

Gene names

Name:	betA
Ordered Locus Names:	PSEEN0372

Organism

Pseudomonas entomophila (strain L48) [Complete proteome] [HAMAP]

Taxonomic identifier

384676 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas

Protein attributes

Sequence length	565 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine By similarity. HAMAP MF_00750
Catalytic activity	Choline + acceptor = betaine aldehyde + reduced acceptor. HAMAP MF_00750
Cofactor	FAD By similarity. HAMAP MF_00750
Pathway	Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (cytochrome c reductase route): step 1/1. HAMAP MF_00750
Sequence similarities	Belongs to the GMC oxidoreductase family.

Ontologies

Keywords
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycine betaine biosynthetic process from choline Inferred from electronic annotation. Source: InterPro
Molecular function	choline dehydrogenase activity Inferred from electronic annotation. Source: EC flavin adenine dinucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 565	565	Choline dehydrogenase HAMAP MF_00750		PRO_1000046568
Regions
	Nucleotide binding	6 – 35	30	FAD Potential
Sites
	Active site	475	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q1IG70 [UniParc]. Last modified June 13, 2006. Version 1. Checksum: 6FF9E83214523B64	FASTA	565	62,392
	10 20 30 40 50 60 MSKEFDYIIV GAGSAGNTLA TRLTEDASVS VLLLEAGGPD YRFDFRTQMP AALAFPLQGR 70 80 90 100 110 120 RYNWAYETDP EPFMDGRRME CGRGKGLGGS SLINGMCYIR GNAMDFDGWA ELPGLEDWTY 130 140 150 160 170 180 LDCLPYFRKA ETRDIGPNDY HGGEGPVSVA TPKAGNNPLF HAMVEAGVQA GYPRTEDLNG 190 200 210 220 230 240 YQQEGFGPMD RSVTKKGRRS STARGYLDQA KKRPNLTIVT HALSDRVLFD GKRAVGVTYL 250 260 270 280 290 300 VGDSEERVEA RARKEVIVSS GAIASPQLLQ RSGVGPRALL ESLDIPVVHD LPGVGENLQD 310 320 330 340 350 360 HLELYLQYAC TQPVSLYPSL LWWNQPAIGA EWLFNGTGIG ASNQFEAGGF IRTRPEFKWP 370 380 390 400 410 420 NIQYHFLPVA INYNGSNGVK EHGFQAHMGS MRSPARGRIQ AKSKDPRQHP SILFNYMSTE 430 440 450 460 470 480 QDWQEFRDGI RLTREIMAQP ALDAFRGREI SPGAHVQTDE ELDKFIREHA ETAFHPSCSC 490 500 510 520 530 540 KMGTDDMAVV DGEGRVHGMQ GLRVVDASIM PLIITGNLNA TTIMIAEKIS DKIRGRKPLP 550 560 RSTAKYYVAG DAPVKGKALR EVKQA

References

[1]

"Complete genome sequence of the entomopathogenic and metabolically versatile soil bacterium Pseudomonas entomophila." Vodovar N., Vallenet D., Cruveiller S., Rouy Z., Barbe V., Acosta C., Cattolico L., Jubin C., Lajus A., Segurens B., Vacherie B., Wincker P., Weissenbach J., Lemaitre B., Medigue C., Boccard F. Nat. Biotechnol. 24:673-679(2006) [PubMed: 16699499] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: L48.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CT573326 Genomic DNA. Translation: CAK13332.1.
RefSeq	YP_606149.1. NC_008027.1.
3D structure databases
ProteinModelPortal	Q1IG70.
ModBase	Search...
Protein-protein interaction databases
STRING	Q1IG70.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4089376.
GenomeReviews	Gene locus PSEEN0372 in contig CT573326_GR.
KEGG	pen:PSEEN0372.
NMPDR	fig|384676.6.peg.325.
PATRIC	19858954. VBIPseEnt83862_0353.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG2303.
HOGENOM	HBG734713.
OMA	EISPGAH.
PhylomeDB	Q1IG70.
ProtClustDB	PRK02106.
Enzyme and pathway databases
BioCyc	PENT384676:PSEEN0372-MONOMER.
Family and domain databases
HAMAP	MF_00750. Choline_dehydrogen. [Tree]
InterPro	IPR011533. Choline_dehydrogenase. IPR012132. GMC_OxRdtase. IPR000172. GMC_OxRdtase_N. IPR007867. GMC_OxRtase_C. [Graphical view]
KO	K00108.
Pfam	PF05199. GMC_oxred_C. 1 hit. PF00732. GMC_oxred_N. 1 hit. [Graphical view]
PIRSF	PIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMs	TIGR01810. BetA. 1 hit.
PROSITE	PS00623. GMC_OXRED_1. 1 hit. PS00624. GMC_OXRED_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

BETA_PSEE4

Accession

Primary (citable) accession number: Q1IG70

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	June 13, 2006
Last modified:	January 25, 2012
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program